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ST271 

Cat. No.: HY-103097 Purity: 98.90%
Handling Instructions

ST271 is a potent inhibitor of protein tyrosine kinase (PTK), inhibits phospholipase D activation stimulated by fMet-Leu-Phe and PAF, with IC50s of 6.7 and 9 μM, respectively.

For research use only. We do not sell to patients.

ST271 Chemical Structure

ST271 Chemical Structure

CAS No. : 106392-48-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
50 mg USD 420 In-stock
Estimated Time of Arrival: December 31
100 mg USD 640 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

ST271 is a potent inhibitor of protein tyrosine kinase (PTK), inhibits phospholipase D activation stimulated by fMet-Leu-Phe and PAF, with IC50s of 6.7 and 9 μM, respectively.

IC50 & Target

IC50: 6.7 μM (phospholipase D, stimulated by fMet-Leu-Phe), 9 μM (phospholipase D, stimulated by PAF)[3]

In Vitro

ST271 partially inhibits peptide phosphorylation in the membrane preparation and in permeabilized platelets[1]. ST271 (100 μM) causes complete inhibition of formation of inositol phosphates induced by FcγRII cross-linking, but also induces a small (< 30%) but significant inhibition of the response to thrombin and U46619[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

272.34

Formula

C₁₆H₂₀N₂O₂

CAS No.

106392-48-7

SMILES

O=C(N)/C(C#N)=C/C1=CC(C(C)C)=C(O)C(C(C)C)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 110 mg/mL (403.91 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6719 mL 18.3594 mL 36.7188 mL
5 mM 0.7344 mL 3.6719 mL 7.3438 mL
10 mM 0.3672 mL 1.8359 mL 3.6719 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

ST271ST 271ST-271PhospholipaseInhibitorinhibitorinhibit

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Product Name:
ST271
Cat. No.:
HY-103097
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