5-HT Receptor
Serotonin Receptor; 5-hydroxytryptamine Receptor
5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. Type: 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7. They mediate both excitatory and inhibitory neurotransmission. The serotonin receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand. The serotonin receptors modulate the release of many neurotransmitters, as well as many hormones. The serotonin receptors influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, andthermoregulation. The serotonin receptors are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics, anorectics,antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens.
5-HT Receptor Isoform Specific Products
-
5-HT Receptor
(569)
View all products
-
5-HT1 Receptor
(458)
View all products
-
5-HT2 Receptor
(476)
View all products
-
5-HT3 Receptor
(34)
View all products
-
5-HT4 Receptor
(18)
View all products
-
5-HT5 Receptor
(14)
View all products
-
5-HT6 Receptor
(86)
View all products
-
5-HT7 Receptor
(89)
View all products
All Product Categories
-
5-HT Receptor Inhibitors
(197)
View all products
-
5-HT Receptor Agonists
(553)
View all products
-
5-HT Receptor Antagonists
(684)
View all products
-
5-HT Receptor Activators
(19)
View all products
-
5-HT Receptor Modulators
(98)
View all products
-
5-HT Receptor Inducers
(2)
View all products
-
5-HT Receptor Controls
(20)
View all products
-
5-HT Receptor Ligands
(32)
View all products
-
5-HT Receptor Related Products (1754)
Related Products (1754)
-
Antibodies (1)
-
Related Compound Screening Libraries (1)
-
5-HT Receptor Isoform Comparison
-
R-137696
0 ImagesCat. No.: HY-167675CAS No.: 695185-73-0R-137696 is an orally active serotonin-1A (5-HT1A) receptor agonist which relaxes the proximal stomach. R-137696 can be utilized in research related to functional dyspepsia.
-
AL-38022A
0 ImagesCat. No.: HY-182472CAS No.: 478132-11-5AL-38022A is a potent and selective 5-HT2 receptor agonist (Ki ≤2.2 nM), but a significantly lower (>100-fold less) affinity for other 5-HT receptors. AL-38022A potently stimulates functional responses via 5-HT2 receptor subtypes including [Ca2+]i mobilization and tissue contractions with apparently similar potencies and intrinsic activities. AL-38022A fully generalizes to the (±)-1-(2,5-dimethoxy 4-methylphenyl)-2-aminopropane hydrochloride (DOM) stimulus in drug discrimination paradigms. AL-38022A can be used for the glaucoma research.
-
LY320135
0 ImagesCat. No.: HY-W011040CAS No.: 176977-56-3LY320135 is a potent and selective antagonist of CB1 receptor, with a Ki of 141 nM. LY320135 also binds to 5-HT2 and muscarinic receptors with Kis of 6.4 μM and 2.1 μM, respectively. LY320135 exhibits neuroprotective effect.
-
AVN-211
0 ImagesCat. No.: HY-105998CAS No.: 1173103-84-8AVN-211 (CD-008-0173) is a selective and orally active 5HT6R antagonist with an IC50 of 2.34 nM and a Ki of 1.09 nM. AVN-211 exhibits 5K-fold higher 5HT6R selectivity over other 65 receptors, enzymes, and ion channels. AVN-211 significantly improves cognitive and anxiety behaviors in various AD animal models, and has good safety profiles. AVN-211 can be used for the study of Alzheimer's dementia.
-
Serotonin-13C,D4
0 ImagesCat. No.: HY-B1473S2CAS No.: 1269486-67-0Synonyms: 5-Hydroxytryptamine-13C,D4; 5-HT-13C,D4
-
SDZ 208-912
0 ImagesCat. No.: HY-19029CAS No.: 101000-49-1SDZ 208-912 is a dual-action 5-HT1A/2 receptor agonist and dopamine D1 receptor antagonist. SDZ 208-912 exhibits partial dopamine agonism and atypical neurosedative effects in rodent models. SDZ 208-912 can be used in research on neurological disorders such as schizophrenia.
-
Buspirone-d8 hydrochloride
0 ImagesCat. No.: HY-B1115SCAS No.: 1216761-39-5Buspirone-d8 (hydrochloride) is the deuterium labeled Buspirone hydrochloride. Buspirone hydrochloride is an anxiolytic psychotropic agent, is used to treat generalized anxiety disorder (GAD).
-
Arotinolol hydrochloride
0 ImagesArotinolol hydrochloride is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol hydrochloride also shows potency for inhibiting the binding of the radioligand 125I-ICYP to 5HT1B-serotonergic receptor sites. Arotinolol hydrochloride is an antihypertensive agent for the treatment of a variety of cardiovascular pathologies as well as non-cardiovascular diseases.
-
Osemozotan
0 ImagesCat. No.: HY-100426CAS No.: 137275-81-1Synonyms: MKC242 free baseOsemozotan (MKC242 free base) acts as an agonist for the 5-HT(1A) receptor.
-
Ro4368554
0 ImagesCat. No.: HY-135456CAS No.: 478082-99-4Ro4368554 is a brain-penetrant and selective 5-HT6 antagonist that reverses memory deficits induced by scopolamine and tryptophan depletion. Ro4368554 can be utilized in research related to memory deficits.
-
(+)-OSU6162
0 Images(+)-OSU6162 is an stabilizer on dopaminergic and serotonergic brain signaling. (+)-OSU6162 is a partial agonist of 5-HT2A receptor. (+)-OSU6162 can be used for neurological research.
-
S18327
0 ImagesCat. No.: HY-165527CAS No.: 200398-40-9S18327 is a multi-target antipsychotic agent. S18327 exerts its efficacy by acting on multiple neurotransmitter systems in the brain, and it has antagonistic effects on dopamine receptors (particularly the D2 receptor) and 5-hydroxytryptamine 2A receptors (5-HT2A receptor). S18327 can counteract excessive dopamine activity and hypo-function of glutamate. S18327 exhibits a multi-parameter pharmacological profile that is highly similar to that of Clozapine (HY-14539). S18327 can produce the same discriminative stimulus as Clozapine, improve cognitive filtering deficits associated with schizophrenia, and display anxiolytic properties. S18327 has relatively weak affinity for histaminergic receptors and muscarinic receptors, which avoids the side effects of Clozapine.
-
PD 158771
0 ImagesCat. No.: HY-167648CAS No.: 189152-50-9PD 158771 is an antipsychotic agent that functions as a partial agonist for D2 /D3 receptors (Ki = 42.0/13.7 nM) and as an agonist for 5-HT1A receptors (Ki = 2.6 nM). PD 158771 can be utilized in antipsychotic research.
-
Dimethothiazine mesylate
0 ImagesCat. No.: HY-A0157ACAS No.: 13115-40-7Synonyms: Dimetotiazine mesylate; Fonazine mesylateDimethothiazine mesylate is an orally active tricyclic anti-histamine, anti-5-HT agent with a high activity against decerebrate rigidity, a little sedative activity and little soporific action. Dimethothiazine mesylate can reduce or abolish the effects of both static and dynamic fusimotor activity on the muscle spindle in decerebrate cat. Dimethothiazine mesylate can be used to research hemicrania and spasticity.
-
4-Chloro Trazodone hydrochloride (Standard)
0 ImagesCat. No.: HY-148718RCAS No.: 1263278-77-84-Chloro Trazodone (hydrochloride) (Standard) is the analytical standard of 4-Chloro Trazodone (hydrochloride). This product is intended for research and analytical applications. 4-Chloro Trazodone hydrochloride is an isomer of Trazodone hydrochloride (HY-B0478). Trazodone hydrochloride is an antidepressant belonging to the class of serotonin receptor antagonists and reuptake inhibitors for treatment of anxiety disorders.
-
25I-NBF hydrochloride
0 ImagesCat. No.: HY-135241CAS No.: 1539266-13-125I-NBF hydrochloride is a highly potent partial agonist for the 5-HT2A receptors receptor with a Ki value of 0.26 nM and an EC50 value of 1.6 nM.
-
Trimipramine (Standard)
0 ImagesCat. No.: HY-B1213ARCAS No.: 739-71-9Trimipramine (Standard) is the analytical standard of Trimipramine. This product is intended for research and analytical applications. Trimipramine is a 5-HT receptor antagonist, with pKi binding values of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively. Trimipramine is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC50 values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively. Trimipramine has vascular activity and anxiolytic efficacy.
-
Asenapine-13C,d3
0 ImagesCat. No.: HY-10121S2CAS No.: 2747915-30-4Synonyms: Org 5222-13C,d3Asenapine-13C,d3 is 13C and deuterated labeled Asenapine (HY-10121). Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder.
-
E6801
0 ImagesCat. No.: HY-123272CAS No.: 528859-04-3E6801 is a 5-HT6 receptor agonist that improves recognition memory by jointly modulating cholinergic and glutamatergic neurotransmission. E6801 can be used in studies of dementia, depression, obesity, epilepsy, etc.
-
(R)-LY-41
0 ImagesCat. No.: HY-165624BCAS No.: 136296-43-0(R)-LY-41, R-enantiomer of LY-41 (HY-165624), is 2-Sminotetralin (HY-W022362) derivative and 8-OH-DPAT (HY-112061) analogue. (R)-LY-41 is a potent and selective 5-HT1A receptor agonist. (R)-LY-41 can reduce the accumulation of 5-hydroxytryptophan (the precursor for 5-HT synthesis) in the rat brain induced by decarboxylase inhibitors (NSD 1015). (R)-LY-41 can lower the body temperature of rats and inhibit the escape response from the cage. (R)-LY-41 can induce the 5-HT behavioral syndrome but is weaker than (S)-LY-41 (HY-165624A). (R)-LY-41 can be used for the research of neurological disease, such as depression and anxiety.
