Cholinesterase (ChE)
Cholinesterase (ChE) is a family of enzymes present in the central nervous system, particularly in nervous tissue, muscle and red cells, which catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. It is one of many important enzymes needed for the proper functioning of the nervous systems of humans.
There are two types: acetylcholinesterase (AChE, acetylcholine hydrolase) and butyrylcholinesterase (BChE, acylcholine acylhydrolase), also known as nonspecific cholinesterase or pseudocholinesterase. AChE is primarily found in the blood on red blood cell membranes, in neuromuscular junctions, and in neural synapses, while BChE is produced in the liver and found primarily in plasma. The difference between the two types of cholinesterase is their relative preferences for substrates: AChE hydrolyzes acetylcholine faster while BChE hydrolyzes butyrylcholine faster.
Cholinesterase (ChE) Isoform Specific Products
All Product Categories
-
Cholinesterase (ChE) Inhibitors
(946)
View all products
-
Cholinesterase (ChE) Agonists
(5)
View all products
-
Cholinesterase (ChE) Antagonists
(10)
View all products
-
Cholinesterase (ChE) Activators
(34)
View all products
-
Cholinesterase (ChE) Modulators
(11)
View all products
-
Cholinesterase (ChE) Chemical
(1)
View all products
-
Cholinesterase (ChE) Inducer
(1)
View all products
-
Cholinesterase (ChE) Controls
(6)
View all products
-
Cholinesterase (ChE) Substrates
(3)
View all products
-
Cholinesterase (ChE) Related Products (1095)
Related Products (1095)
-
Antibodies (2)
-
Cholinesterase (ChE) Isoform Comparison
-
AL284
0 ImagesCat. No.: HY-169173CAS No.: 2270876-07-6AL284 is a potent anopheles gambiae acetylcholinesterase 1 (AgAChE1) inhibitor. AL284 interactions with Tyr489Ag in the α-helix next to loop 2, and Trp441Ag at the top of the gorge. AL284 has the potential for the research of disease-transmitting mosquitoes.
-
BChE-IN-53
0 ImagesCat. No.: HY-W1058380CAS No.: 25870-73-9BChE-IN-53 is a butyrylcholinesterase (BChE) inhibitor with an IC50 value of 119.0 μM and is inactive against α-glucosidase. BChE-IN-53 can be used for the research of alzheimer's disease, type 2 diabetes mellitus.
-
Neostigmine hydroxide
0 ImagesCat. No.: HY-119792ACAS No.: 588-17-0Neostigmine hydroxide is a cholinesterase inhibitor and can be used for study of myasthenia gravis.
-
4'-O-Methylcatechin
0 ImagesCat. No.: HY-W740798CAS No.: 69912-75-04'-O-Methylcatechin acts as a lipase and acetylcholinesterase inhibitor, with an IC50 of 149.93 μM against lipase and an IC50 of 230.89 μM against electric eel-derived acetylcholinesterase. 4'-O-Methylcatechin possesses free radical scavenging activity and can be used in studies on antioxidation, antilipase activity and dementia.
-
AChE-IN-73
0 ImagesCat. No.: HY-163980AChE-IN-73 (compound 6) is an insecticide with higher toxicity than HY-B0815. The LC50 for C. pipiens is 78.0 mg/L. AChE-IN-73 has high affinity for acetylcholinesterase (AChE) and nicotinic acetylcholine receptors (nAChR), with binding energies of -8.11 kcal/mol and -6.27 kcal/mol, respectively. AChE-IN-73 is a potentially potent mosquito inhibitor.
-
Heptenophos
0 ImagesCat. No.: HY-120042CAS No.: 23560-59-0Heptenophos is an inhibitor of AChE and plasma carboxylesterase (CES). By inhibiting AChE activity, Heptenophos causes the accumulation of acetylcholine at cholinergic synapses, thereby triggering typical symptoms of organophosphate poisoning. Heptenophos exhibits rapid lethal toxicity in male albino mice, but its toxic effects are effectively antagonized by obidoxime, and Memantine (HY-B0591) further enhances the detoxification efficacy of obidoxime. Therefore, Heptenophos is commonly used in studies related to the mechanism of organophosphate poisoning and detoxification strategies.
-
Pirimiphos-methyl (Standard)
0 ImagesCat. No.: HY-B1881RCAS No.: 29232-93-7Pirimiphos-methyl (Standard) is the analytical standard of Pirimiphos-methyl (HY-B1881). This product is intended for research and analytical applications. Pirimiphos-methyl is an organophosphorus insecticide and acaricide that can inhibit AChE in target organisms. Pirimiphos-methyl is often used for prevention and control of beetles, snout beetles, moths and Ephestia cautella during storage of agricultural grains.
-
Arisugacin G
0 ImagesCat. No.: HY-N13927CAS No.: 261951-57-9Arisugacin G, a microbial metabolite, is a structural analog of Arisugacin A (HY-N13901). Arisugacin G shows no activity against AChE.
-
Salvianolic acid H
0 ImagesCat. No.: HY-W782096CAS No.: 444179-57-1Salvianolic acid H is a potent acetylcholinesterase (AChE) inhibitor.
-
D-Ribose-L-cysteine
0 ImagesD-Ribose-L-cysteine is an orally active cysteine analog. D-Ribose-L-cysteine improves cellular antioxidant capacity by enhancing intracellular glutathione (GSH) biosynthesis. In addition, D-Ribose-L-cysteine has a memory-enhancing effect and can reverse Scopolamine (HY-N0296)-induced memory impairment by inhibiting oxidative stress and acetylcholinesterase (AChE) activity. D-Ribose-L-cysteine can be used in the study of neurodegenerative and cardiovascular diseases.
-
Itopride hydrochloride (Standard)
0 ImagesSynonyms: HSR803 (Standard)Itopride (hydrochloride) (Standard) is the analytical standard of Itopride (hydrochloride). This product is intended for research and analytical applications. Itopride (HSR803) hydrochloride is a potent dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride hydrochloride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD).
-
7-Methoxytacrine
0 ImagesCat. No.: HY-W049312CAS No.: 5778-80-3Synonyms: 7-MEOTA7-Methoxytacrine (7-MEOTA) is an inhibitor of human acetylcholinesterase (hAChE) with an IC50 value of 10 μM, and can be used for the research of Alzheimer's disease (AD).
-
ZINC12613047
0 ImagesCat. No.: HY-113905CAS No.: 1069521-64-7ZINC12613047 is a selective BChE inhibitor with an IC50 of 0.021 μM against huBChE. ZINC12613047 can be used for the research of Alzheimer's disease.
-
SMase-IN-1
0 ImagesCat. No.: HY-170650CAS No.: 33017-85-5SMase-IN-1 (Compound 4) is a bacterial sphingomyelinase enzyme (SMase) inhibitor (IC50 value for B. cereus SMase is 6.43 µM). SMase-IN-1 also inhibits eqBuChE (59.50% inhibition rate at 50 µM concentration). SMase-IN-1 forms a complex with Cu2+ in biometal interactions. SMase-IN-1 reduces B. cereus-induced hemolysis on sheep erythrocytes.
-
Penconazole-d7
0 ImagesPenconazole-d7 is the deuterium labeled Penconazole. Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats.
-
Chlorpyrifos-oxon (Standard)
0 ImagesChlorpyrifos-oxon (Standard) is the analytical standard of Chlorpyrifos-oxon. This product is intended for research and analytical applications. Chlorpyrifos-oxon, an active metabolite of Chlorpyrifos, is a potent phosphorylating agent that potently inhibits AChE. Chlorpyrifos-oxon can induce cross-linking between subunits of tubulin and disrupt microtubule function.
-
Trimyristin (Standard)
0 ImagesTrimyristin (Standard) is the analytical standard of Trimyristin (HY-N2511). This product is intended for research and analytical applications. Trimyristin is an orally active compound. Trimyristin can be isolated from the seeds of nutmeg (Myristica fragrans). Trimyristin inhibits the activities of acetylcholinesterase (AChE), ACP and ALP, with IC50 values of 0.11, 0.16 and 0.18 mM, respectively. Trimyristin exerts competitive-noncompetitive inhibition on acetylcholinesterase, uncompetitive inhibition on ACP, and competitive/noncompetitive inhibition on ALP. Trimyristin restores the downregulated acetylcholinesterase concentration in the cerebral cortex of rats exposed to sodium arsenite. Trimyristin can be used in studies related to fascioliasis and neurotoxicity.
