AMPK
AMP-activated protein kinase
AMPK (AMP-activated protein kinase) is an enzyme that plays a role in cellular energy homeostasis. It consists of three proteins (subunits) that together make a functional enzyme. The net effect of AMPK activation is stimulation of hepatic fatty acid oxidation andketogenesis, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, stimulation of skeletal muscle fatty acid oxidation and muscle glucose uptake by pancreatic beta-cells. AMPK acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.
AMPK Isoform Specific Products
-
NUAK1
(10)
View all products
-
NUAK2
(5)
View all products
-
AMPK
(353)
View all products
-
AMPK α1β1γ1
(12)
View all products
-
AMPK α2β1γ1
(8)
View all products
-
AMPK α1β2γ1
(5)
View all products
-
AMPK α2β2γ1
(6)
View all products
-
BRSK1
(1)
View all products
-
BRSK2
(1)
View all products
-
HUNK
(1)
View all products
-
AMPKα
(2)
View all products
All Product Categories
-
AMPK Inhibitors
(79)
View all products
-
AMPK Agonists
(17)
View all products
-
AMPK Antagonists
(2)
View all products
-
AMPK Activators
(325)
View all products
-
AMPK Modulators
(7)
View all products
-
AMPK Inducers
(4)
View all products
-
AMPK Substrate
(1)
View all products
-
AMPK Proteins
(7)
View all products
-
AMPK Related Products (486)
Related Products (486)
-
Recombinant Proteins (7)
-
Antibodies (17)
-
AMPK Isoform Comparison
-
Dorsomorphin (Standard)
0 ImagesCat. No.: HY-13418ARCAS No.: 866405-64-3Synonyms: BML-275 (Standard)Dorsomorphin (Standard) is the analytical standard of Dorsomorphin (HY-13418A). This product is intended for research and analytical applications. Dorsomorphin (BML-275) is a selective and ATP-competitive AMPK inhibitor (Ki=109 nM in the absence of AMP). Dorsomorphin (BML-275) selectively inhibits BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599).
-
Alisol A (Standard)
0 ImagesCat. No.: HY-N0853RCAS No.: 19885-10-0Alisol A (Standard) is the analytical standard of Alisol A (HY-N0853). This product is intended for research and analytical applications. Alisol A is an orally active tetracyclic triterpenoid compound of the prototerpane type. Alisol A can be extracted from the rhizome of Alisma orientale. Alisol A activates AMPK/ACC/SREBP-1c, SIRT1, PPARα, inhibits MMP-2/-9, decreases inflammatory cytokine expression (IL-1β, IL-6, IL-8). Alisol A has anti-tumor activity against breast cancer and colorectal cancer. Alisol A has anti-obesity and anti-atherosclerotic activities. Alisol A can be used in the research of hepatitis B, breast cancer, colorectal cancer, atherosclerosis, and obesity.
-
ZLN024
0 ImagesCat. No.: HY-16708CAS No.: 723249-01-2ZLN024 is an AMPK allosteric activator. ZLN024 directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC50s of 0.42 µM, 0.95 µM, 1.1 µM and 0.13 µM, respectively.
-
Dorsomorphin dihydrochloride (Standard)
0 ImagesSynonyms: Compound C dihydrochloride (Standard); BML-275 dihydrochloride (Standard)Dorsomorphin (dihydrochloride) (Standard) is the analytical standard of Dorsomorphin (dihydrochloride). This product is intended for research and analytical applications. Dorsomorphin (Compound C) dihydrochloride is a potent, selective and ATP-competitive AMPK inhibitor, with a Ki of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin dihydrochloride can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599).
-
Metformin-13C2 (hydrochloride)
0 ImagesCat. No.: HY-B0627S1Synonyms: 1,1-Dimethylbiguanide-13C2 hydrochlorideMetformin-13C2 (1,1-Dimethylbiguanide-13C2) hydrochloride is the 13C-labeled Metformin hydrochloride (HY-17471A). Metformin (1,1-Dimethylbiguanide) hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo.
