Adenosine Receptor
Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which mediate the physiological actions of adenosine. To date, four AR subtypes have been cloned and identified in different tissues. These receptors have distinct localization, signal transduction pathways and different means of regulation upon exposure to agonists. A key property of some of Adenosine receptors is their ability to serve as sensors of cellular oxidative stress, which is transmitted by transcription factors, such as NF-κB, to regulate the expression of ARs. The importance of Adenosine receptors in the regulation of normal and pathological processes such as sleep, the development of cancers and in protection against hearing loss will be examined.
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Adenosine Receptor Inhibitors
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Adenosine Receptor Agonists
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Adenosine Receptor Antagonists
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Adenosine Receptor Activators
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Adenosine Receptor Modulators
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Adenosine Receptor Ligands
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Adenosine Receptor Related Products (305)
Related Products (305)
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MNI-444
0 ImagesCat. No.: HY-125602CAS No.: 1974301-94-4MNI-444 is a BBB-penetrable ligand of adenosine 2A receptor (A2AR). A2AR is a potential non-dopaminergic target for the research of Parkinson’s disease.
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GS-6201 (Standard)
0 ImagesCat. No.: HY-10081RCAS No.: 752222-83-6Synonyms: CVT-6883 (Standard)GS-6201 (Standard) is the analytical standard of GS-6201 (HY-10081). This product is intended for research and analytical applications. GS-6201 (CVT-6883) is a selective adenosine A2B receptor antagonist. GS-6201 displays high affinity and selectivity for the human adenosine A2B receptors (Ki=22 nM). GS-6201 reduces caspase-1 activity in the heart, and attenuates cardiac remodeling after acute myocardial infarction (AMI) in the mouse. GS-62013 attenuates the airway reactivity induced by NECA, AMP, or allergen in sensitized mice.
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BAY-545 (Standard)
0 ImagesCat. No.: HY-111767RCAS No.: 1699717-32-2BAY-545 (Standard) is the analytical standard of BAY-545 (HY-111767). This product is intended for research and analytical applications. BAY-545 is a potent and selective A2B adenosine receptor antagonist, with an IC50 of 59 nM. BAY-545 also exhibits IC50s of 66, 400, 280 nM for human, mouse, rat A2B adenosine receptor in cells, respectively, and a Ki of 97 nM for human A2B adenosine receptor, with more selectivity over A1, A2A, and A3 adenosine receptor.
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Methylliberine (Standard)
0 ImagesCat. No.: HY-N7564RCAS No.: 51168-26-4Methylliberine (Standard) is the analytical standard of Methylliberine (HY-N7564). This product is intended for research and analytical applications. Methylliberine is an orally active adenosine A1 receptor modulator. Methylliberine inhibits spermatogenesis and induces testicular atrophy.
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N-(7H-Purin-6-yl)acetamide
0 ImagesCat. No.: HY-W424876CAS No.: 6034-68-0N-(7H-Purin-6-yl)acetamide (Compound 25) is a selective adenosine receptor (AdeR) agonist with a Ki value of 0.515 μM for the human adenosine receptor and a Ki value of 2.85 μM for the rat adenosine receptor. N-(7H-Purin-6-yl)acetamide is promising for research of adenosine receptor function, pain perception, inflammatory responses, and renal function.
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CCD-2
0 ImagesCat. No.: HY-160281CAS No.: 2271351-19-8CCD-2 is a conventional detergent and is readily degraded. CCD-2 can efficiently solubilize and stabilize diverse G protein-coupled receptors (GPCRs). CCD-2 is amenable to the β-barrel protein research. The chemical cleavage of CCD-2 is rapid, complete and biorthogonal and should facilitate a chemical methodology for in situ detergent replacement in diverse membrane proteins (MPs) studies.
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PSB-603 (Standard)
0 ImagesCat. No.: HY-103166RCAS No.: 1092351-10-4PSB-603 (Standard) is the analytical standard of PSB-603 (HY-103166). This product is intended for research and analytical applications. PSB-603 is a potent and highly selective A2B adenosine receptor antagonist exhibiting a Ki value of 0.553 nM and virtually no affinity for the human and rat A1 and A2A and the human A3 receptors up to a concentration of 10 μM.
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FK 453 (Standard)
0 ImagesCat. No.: HY-105275ARCAS No.: 121524-18-3FK 453 (Standard) is the analytical standard of FK 453 (HY-105275A). This product is intended for research and analytical applications. FK 453 (compound 1d) is a potent and selective adenosine A1 receptor antagonist with an IC50 value of 17.2 nM.
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2-Thioadenosine
0 ImagesCat. No.: HY-W069173CAS No.: 43157-50-22-Thioadenosine is a selective A1 adenosine receptor (A1AR) ligand with a Ki of 80.3 nM. 2-Thioadenosine shows very low affinity for the A2A, A2B and A3 adenosine receptor subtypes. 2-Thioadenosine acts as a precursor for the synthesis of fluorescent A3 adenosine receptor-selective agonists.
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5'-N-Ethylcarboxamidoadenosine (Standard)
0 ImagesSynonyms: NECA (Standard)5'-N-Ethylcarboxamidoadenosine (Standard) is the analytical standard of 5'-N-Ethylcarboxamidoadenosine. This product is intended for research and analytical applications. 5'-N-Ethylcarboxamidoadenosine (NECA) is a nonselective adenosine receptor agonist.
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PSB-0788 (Standard)
0 ImagesCat. No.: HY-103165RCAS No.: 1027513-54-7PSB-0788 (Standard) is the analytical standard of PSB-0788 (HY-103165). This product is intended for research and analytical applications. PSB-0788 is a new selective high-affinity A2B antagonist with IC50 value of 3.64 nM and Ki value of 0.393 nM, respeactively. PSB-0788 can be used for the research for chronic inflammatory lung diseases.
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Rolofylline (Standard)
0 ImagesSynonyms: KW-3902 (Standard)Rolofylline (Standard) is the analytical standard of Rolofylline. This product is intended for research and analytical applications. Rolofylline (KW-3902) is a potent, selective adenosine A1 receptor antagonist that is under development for the treatment of patients with acute congestive heart failure and renal impairment. Rolofylline is metabolized primarily to the pharmacologically active M1-trans and M1-cis metabolites by cytochrome P450 (CYP450). Rolofylline is alleviating the presynaptic dysfunction and restores neuronal activity as well as dendritic spine levels in vitro, is an interesting candidate to combat the hypometabolism and neuronal dysfunction associated with Tau-induced neurodegenerative diseases.
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Adenosine-2'-monophosphate (Standard)
0 ImagesCat. No.: HY-124151RCAS No.: 130-49-4Synonyms: 2'-AMP (Standard); Adenosine 2'-phosphate (Standard); AMP 2'-phosphate (Standard)Bisphenol A diglycidyl ether (Standard) is the analytical standard of Bisphenol A diglycidyl ether. This product is intended for research and analytical applications. Bisphenol A diglycidyl ether is used as a stabilizer and embedding agent.
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Bamifylline hydrochloride
0 ImagesCat. No.: HY-121453CAS No.: 20684-06-4Bamifylline hydrochloride is a drug in the chemical class of xanthine that acts as a selective adenosine A1 receptor antagonist.
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Flavoxate-d4 (hydrochloride)
0 ImagesCat. No.: HY-B0549ASCAS No.: 1189678-43-0Flavoxate-d4 hydrochloride (Rec-7-0040-d4) is the deuterium labeled Flavoxate hydrochloride. Flavoxate hydrochloride (Rec-7-0040; DW61) is an orally active L-type Ca2+ channel inhibitor and antispasmodic. Flavoxate hydrochloride inhibits cyclic adenosine monophosphate production by blocking voltage-dependent inward Ba2+ currents, regulating the brainstem micturition center, and stimulating G protein-coupled receptors. Consequently, Flavoxate hydrochloride induces relaxation of bladder smooth muscle and inhibits isovolumetric rhythmic contractions. Flavoxate hydrochloride effectively increases bladder capacity and alleviates symptoms of urgent urination frequency and pollakiuria caused by overactive bladder. Flavoxate hydrochloride can be used in research on overactive bladder and related voiding dysfunctions.
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Taminadenant (Standard)
0 ImagesCat. No.: HY-109139RCAS No.: 1337962-47-6Synonyms: NIR178 (Standard); PBF509 (Standard)Taminadenant (Standard) is the analytical standard of Taminadenant (HY-109139). This product is intended for research and analytical applications. Taminadenant (NIR178; PBF509) is a highly potent and orally active adenosine A2A receptor (A2AR) antagonist. Taminadenant can antagonize A2AR agonist-mediated cAMP accumulation and impedance responses with KB values of 72.8 nM and 8.2 nM, respectively. Taminadenant reverses motor impairments in several rat models of movement disorders, including catalepsy, tremor, and hemiparKinsonism. Taminadenant can also inhibit tumor growth when combined with Spartalizumab (HY-P9972). Taminadenant reactivate the antitumor immune response.
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XCC
0 ImagesCat. No.: HY-103168CAS No.: 96865-83-7XCC, 1,3,8-substituted xanthine derivative, is an adenosine receptor antagonist with Ki of 1.905 μM[1].
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SCH442416 (Standard)
0 ImagesCat. No.: HY-103169RCAS No.: 316173-57-6SCH442416 (Standard) is the analytical standard of SCH442416. This product is intended for research and analytical applications. SCH442416 is a potent, selective and brain-penetrant antagonist of adenosine A2A receptor (A2AR), with Kis of 0.048 and 0.5 nM for human and rat A2AR respectively. SCH442416 displays more than 23000-fold selectivity over A1R, A2BR, and A3R (Ki=1111, 10000, and 10000 nM, respectively). SCH442416 can be used for imaging of adenosine A2A receptors in rat and primate brain.
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ST4206
0 ImagesCat. No.: HY-U00341CAS No.: 1246018-36-9ST4206 is a potent and orally active adenosine A2A receptor antagonist, with Kis of 12 nM and 197 nM for adenosine A2A receptor and adenosine A1 receptor, respectively. ST4206 has the potential for Parkinson׳s disease research.
