Adenosine Receptor
Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which mediate the physiological actions of adenosine. To date, four AR subtypes have been cloned and identified in different tissues. These receptors have distinct localization, signal transduction pathways and different means of regulation upon exposure to agonists. A key property of some of Adenosine receptors is their ability to serve as sensors of cellular oxidative stress, which is transmitted by transcription factors, such as NF-κB, to regulate the expression of ARs. The importance of Adenosine receptors in the regulation of normal and pathological processes such as sleep, the development of cancers and in protection against hearing loss will be examined.
All Product Categories
-
Adenosine Receptor Inhibitors
(27)
View all products
-
Adenosine Receptor Agonists
(88)
View all products
-
Adenosine Receptor Antagonists
(137)
View all products
-
Adenosine Receptor Activators
(7)
View all products
-
Adenosine Receptor Modulators
(10)
View all products
-
Adenosine Receptor Ligands
(11)
View all products
-
Adenosine Receptor Related Products (305)
Related Products (305)
-
Doxofylline (Standard)
0 ImagesDoxofylline (Standard) is the analytical standard of Doxofylline. This product is intended for research and analytical applications. Doxofylline is an orally active PDE IV inhibitor and A1AR antagonist. Doxofylline reduces inflammation in epithelial cells via inhibiting mitochondrial ROS production and amelioration of multiple cellular pathways (NLRP3-TXNIP inflammasome activation). Doxophylline can be used in studies of asthma, chronic obstructive pulmonary disease, and bronchospasm.
-
CCPA (Standard)
0 ImagesCat. No.: HY-103185RCAS No.: 37739-05-2Synonyms: 2-Chloro-N6-cyclopentyladenosine (Standard)CCPA (2-Chloro-N6-cyclopentyladenosine (Standard)) is the analytical standard of CCPA (HY-103185). This product is intended for research and analytical applications. CCPA (2-Chloro-N6-cyclopentyladenosine) a highly selective A1 adenosine receptors agonist with a Ki of 0.4 nM. CCPA inhibits adenylate cyclase with an IC50 of 33 nM. CCPA exhibits anti-seizure and cardiacprotective activity. CCPA can be used for the research of seizure and myocardial infarction.
-
CGS 15943 (Standard)
0 ImagesCat. No.: HY-100678RCAS No.: 104615-18-1CGS 15943 (Standard) is the analytical standard of CGS 15943. This product is intended for research and analytical applications. CGS 15943 is an orally bioavailable non-xanthine Adenosine Receptor antagonist. Its Ki for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM in transfected CHO cells, respectively. .
-
SCH 58261 (Standard)
0 ImagesSCH 58261 (Standard) is the analytical standard of SCH 58261. This product is intended for research and analytical applications. SCH 58261 is a potent, selective and competitive antagonist of adenosine A2A receptor with an IC50 of 15 nM, and displays 323-, 53- and 100-fold more selective for A2A receptor than A1, A2B, and A3 receptors, respectively.
-
Yohimbine Hydrochloride (Standard)
0 ImagesYohimbine Hydrochloride Standard is an alpha-2 renal adenomatase receptor inhibitor, blocking pre- and post-contact alpha-2 renal adenomatase receptors, causing the release of renal adenoma and multiple sclerosis.
-
Xanthine amine congener hydrochloride (Standard)
0 ImagesCat. No.: HY-101139ARCAS No.: 1783977-95-6Synonyms: XAC hydrochloride (Standard)Xanthine amine congener (hydrochloride) (Standard) is the analytical standard of Xanthine amine congener (hydrochloride). This product is intended for research and analytical applications. Xanthine amine congener (XAC) hydrochloride is a non-selective adenosine receptor antagonist. Xanthine amine congener hydrochloride induces convulsions in mice.
-
PSB-1115 potassium salt
0 ImagesCat. No.: HY-103182ACAS No.: 409344-71-4PSB-1115 potassium salt is a selective A2B Adenosine Receptor antagonist. PSB-1115 potassium salt inhibits the 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced contraction inhibition of acetylcholine (ACh).
-
Preladenant (Standard)
0 ImagesCat. No.: HY-10889RCAS No.: 377727-87-2Synonyms: SCH-420814 (Standard)Preladenant (Standard) is the analytical standard of Preladenant. This product is intended for research and analytical applications. Preladenant is a potent and competitive antagonist of the human adenosine A2A receptor with a Ki of 1.1 nM and has over 1000-fold selectivity over other adenosine receptors.
-
N6-Cyclopentyladenosine (Standard)
0 ImagesCat. No.: HY-103181RCAS No.: 41552-82-3Synonyms: CPA (Standard); UK-80882 (Standard)N6-Cyclopentyladenosine (Standard) is the analytical standard of N6-Cyclopentyladenosine (HY-103181). This product is intended for research and analytical applications. N6-Cyclopentyladenosine (CPA) is a selective Adenosine A1 receptor agonist, with Ki values of 2.3 nM, 790 nM and 43 nM for human A1, A2A and A3 receptors, respectively. N6-cyclopentyladenosine increases Apoptosis. N6-Cyclopentyladenosine has antitumor activity against leukemia. N6-cyclopentyladenosine improves 5-fluorouracil (HY-90006)-induced hematopoietic damage, regulates sleep, and delays Aminophylline-induced clonic epileptic seizures.
-
ATL-802
0 ImagesCat. No.: HY-111306CAS No.: 847612-12-8ATL-802 is a potent adenosine A2B receptor antagonist. ATL-802 is promising for research of diabetes.
-
BAY 60-6583 (Standard)
0 ImagesBAY 60-6583 (Standard) is the analytical standard of BAY 60-6583. This product is intended for research and analytical applications. BAY 60-6583 is a potent and high-affinity agonist of adenosine A2B receptor (EC50?= 3 nM) over A1, A2A, and A3 receptors. BAY 60-6583 binds to mouse, rabbit, and dog A2BAR with Ki values of 750 nM, 340 nM and 330 nM, respectively. BAY 60-6583 has a cardioprotective effect in a myocardial ischemia model.
-
Vipadenant (Standard)
0 ImagesSynonyms: BIIB-014 (Standard); CEB-4520 (Standard)Vipadenant (Standard) is the analytical standard of Vipadenant. This product is intended for research and analytical applications. Vipadenant (BIIB-014; CEB-4520) is an adenosine receptor antagonist, with Kis of 1.3 nM and 68 nM for A2A and A1, respectively.
-
Tozadenant (Standard)
0 ImagesCat. No.: HY-10995RCAS No.: 870070-55-6Synonyms: SYN115 (Standard)Tozadenant (Standard) is the analytical standard of Tozadenant (HY-10995). This product is intended for research and analytical applications. Tozadenant is an adenosine A2A receptor antagonist, with Ki of 11.5 nM on human A2A and 6 nM on rhesus A2A.
-
PD81723
0 ImagesPD81723 is an adenosine receptor binding enhancer. PD81723 enhances the inhibition of exogenous adenosine in a dose-dependent manner in hippocampal brain sections.
-
7-Methylxanthine (Standard)
0 Images7-Methylxanthine (Standard) is the analytical standard of 7-Methylxanthine. This product is intended for research and analytical applications. 7-Methylxanthine is an orally active methyl derivative of xanthine and a non-selective adenosine receptor antagonist. 7-Methylxanthine is also one of the purine components of human urinary calculi. 7-Methylxanthine has anti-myopia activity.
-
Diphylline (Standard)
0 ImagesDiphylline (Standard) is the analytical standard of Diphylline. This product is intended for research and analytical applications. Diphylline (Diprophylline) is a potent A1/A2 adenosine receptor antagonist and cyclic nucleotide phosphodiesterase inhibitor. Diphylline, a xanthine derivative, is a bronchodilator and vasodilator agent and has the potential for chronic bronchitis and emphysema.
-
ADORA1 modulator-1
0 ImagesCat. No.: HY-180879CAS No.: 820961-65-7ADORA1 modulator-1 is an ADORA1 modulator.
-
CP-66713
0 ImagesCat. No.: HY-111129CAS No.: 91896-57-0CP-66713 is a selective adenosine A2 receptor antagonist, with Ki of 22 nM. CP-66713 inhibits induction of long-term potentiation of evoked synaptic potentials. CP-66713 can be used in the study of neurological diseases.
-
Acefylline piperazine
0 ImagesCat. No.: HY-B1505ACAS No.: 18833-13-1Synonyms: Theophyllineacetic acid piperazine; Theophylline-7-acetic acid piperazineAcefylline (Theophyllineacetic acid) piperazine, a xanthine derivative, is an Adenosine Receptor antagonist. Acefylline piperazine is a peptidylarginine deiminase (PAD) activator. Acefylline piperazine is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline piperazine can be used in asthma research.
