Adenosine Receptor
Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which mediate the physiological actions of adenosine. To date, four AR subtypes have been cloned and identified in different tissues. These receptors have distinct localization, signal transduction pathways and different means of regulation upon exposure to agonists. A key property of some of Adenosine receptors is their ability to serve as sensors of cellular oxidative stress, which is transmitted by transcription factors, such as NF-κB, to regulate the expression of ARs. The importance of Adenosine receptors in the regulation of normal and pathological processes such as sleep, the development of cancers and in protection against hearing loss will be examined.
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Adenosine Receptor Inhibitors
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Adenosine Receptor Agonists
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Adenosine Receptor Antagonists
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Adenosine Receptor Activators
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Adenosine Receptor Modulators
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Adenosine Receptor Ligands
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Adenosine Receptor Related Products (305)
Related Products (305)
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LUF5831
0 ImagesCat. No.: HY-116837CAS No.: 333963-57-8LUF5831 is a non-adenosine agonist with an affinity of Ki=18 nM for adenosine A1 receptor.
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N6-Benzyladenosine (Standard)
0 ImagesN6-Benzyladenosine (Standard) (Benzyladenosine (Standard)) is the analytical standard of N6-Benzyladenosine (HY-N7844). This product is intended for research and analytical applications. N6-Benzyladenosine is an adenosine receptor agonist, has a cytoactive activity. N6-Benzyladenosine arrests cell cycle at G0/G1 phase and induces cell apoptosis. N6-Benzyladenosine also exerts inhibitory effect on T. gondii adenosine kinase and glioma-.
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LUF 5608
0 ImagesCat. No.: HY-129463CAS No.: 674289-28-2LUF 5608 is a ligand that exhibits high adenosine A1 affinity of 7.7 nM.
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PD 117519 (Standard)
0 ImagesCat. No.: HY-100032RCAS No.: 96392-15-3Synonyms: CI947 (Standard)
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MRS 1523 (Standard)
0 ImagesCat. No.: HY-121119RCAS No.: 212329-37-8MRS 1523 (Standard) is the analytical standard of MRS 1523. This product is intended for research and analytical applications. MRS 1523 is a potent and selective adenosine A3 receptor antagonist with Ki values of 18.9 nM and 113 nM for human and rat A3 receptors, respectively. In rat this corresponds to selectivities of 140- and 18-fold vs A1 and A2A receptors, respectively. MRS 1523 can exert antihyperalgesic effect through N-type Ca channel block and action potential inhibition in isolated rat dorsal root ganglion (DRG) neurons.
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Binodenoson (Standard)
0 ImagesCat. No.: HY-106450RCAS No.: 144348-08-3Synonyms: MRE-0470 (Standard); WRC 0470 (Standard)Binodenoson (Standard) is the analytical standard of Binodenoson (HY-106450). This product is intended for research and analytical applications. Binodenoson (MRE-0470) is a potent and selective A2A adenosine receptor agonist (KD=270 nM). Binodenoson is being developed as a short-acting coronary vasodilator as an adjunct to radiotracers for use in myocardial stress imaging.
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Alloxazine (Standard)
0 ImagesCat. No.: HY-123085RCAS No.: 490-59-5Synonyms: Isoalloxazine (Standard)Alloxazine (Standard) is the analytical standard of Alloxazine. This product is intended for research and analytical applications. Alloxazine is a selective A2b antagonist. Alloxazine completely block 5’N-Ethylcarboxamido adenosine (NECA)-mediated cyclic AMP accumulation with an IC50 of 2.9 μM. Alloxazine can be used for the research of cancer.
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MRS 1754 (Standard)
0 ImagesMRS 1754 (Standard) is the analytical standard of MRS 1754. This product is intended for research and analytical applications. MRS 1754 is a selective antagonist radioligand for A2B adenosine receptor with very low affinity for A1 and A3 receptors of both humans and rats.
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MRS-1706 (Standard)
0 ImagesCat. No.: HY-103186RCAS No.: 264622-53-9MRS-1706 (Standard) is the analytical standard of MRS-1706. This product is intended for research and analytical applications. MRS-1706 is a potent and selective adenosine A2B receptor inverse agonist. MRS-1706 has Ki values of 1.39, 112, 157, and 230 nM for human A2B, A2A, A1 and A3 receptors respectively. MRS-1706 blocks adenosine-mediated cAMP induction.
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Dansyl-NECA
0 ImagesCat. No.: HY-110170CAS No.: 219982-12-4Dansyl-NECA (compound 1) is a dansyl-labeled adenosine receptor antagonist.
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DPCPX (Standard)
0 ImagesSynonyms: PD 116948 (Standard)DPCPX (Standard) is the analytical standard of DPCPX. This product is intended for research and analytical applications. DPCPX (PD 116948), a xanthine derivative, is a highly potent and selective Adenosine A1 receptor antagonist, with a Ki of 0.46 nM in 3H-CHA binding to A1 receptors in rat whole brain membranes.
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Namodenoson (Standard)
0 ImagesSynonyms: CF-102 (Standard); 2-Cl-IB-MECA (Standard)Namodenoson (Standard) is the analytical standard of Namodenoson. This product is intended for research and analytical applications. Namodenoson (CF-102) is a selective A3 adenosine receptor (A3AR) agonist (Ki=0.33 nM). Namodenoson displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively.
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A2AAR antagonist 1
0 ImagesCat. No.: HY-151387CAS No.: 1784491-64-0A2AAR antagonist 1 (compound 21a) is an A2AAR (adenosine A2A receptor) antagonist with a Ki value of 20 nM. A2AAR antagonist 1 shows high ligand efficiency, and it can be used for the research of neurodegenerative diseases.
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N6-(2-Phenylethyl)adenosine (Standard)
0 ImagesCat. No.: HY-101854RCAS No.: 20125-39-7Synonyms: N6-Phenethyladenosine (Standard); N6-Phenylethyladenosine (Standard)N6-(2-Phenylethyl)adenosine (Standard) (N6-Phenethyladenosine (Standard)) is the analytical standard of N6-(2-Phenylethyl)adenosine (HY-101854). This product is intended for research and analytical applications. N6-(2-Phenylethyl)adenosine (N6-Phenethyladenosine), an adenosine derivative, is a potent adenosine receptors (AR) agonist with Ki values of 11.8 nM, 30.1 nM, 0.63 nM for rat A1AR, human A1AR and hA3AR, respectively.
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Adenosine monophosphate-13C10,15N5
0 ImagesCat. No.: HY-A0181S6Synonyms: AMP-13C10,15N5Adenosine monophosphate-13C10,15N5 (AMP-13C10,15N5) is the 13C- and 15N-labeled Adenosine monophosphate (HY-A0181). Adenosine monophosphate is an adenosine A1 receptor agonist. Adenosine monophosphate has significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction.
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Propentofylline-d6
0 ImagesCat. No.: HY-107203SCAS No.: 1216516-37-8Synonyms: HWA 285-d6Propentofylline-d6 (HWA 285-d6) is the deuterium labeled Propentofylline. Propentofylline is an orally active and brain-penetrant phosphodiesterase inhibitor. Propentofylline blocks adenosine reuptake and prevents cyclic nucleotide degradation. Propentofylline can be used for the research of primary degenerative (Alzheimer's) dementia, vascular dementia, cerebral ischemia, acute stroke, and learning and memory disorders.
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LUF5981
0 ImagesCat. No.: HY-111088CAS No.: 929641-63-4LUF5981 is a relatively potent adenosine A2A receptor (A2A) antagonist with pIC50 value of 6.7.
