1. GPCR/G Protein
  2. Adenosine Receptor
  3. Binodenoson

Binodenoson (Synonyms: MRE-0470; WRC 0470)

Cat. No.: HY-106450
Handling Instructions

Binodenoson (MRE-0470) is a potent and selective A2A adenosine receptor agonist (KD=270 nM). Binodenoson is being developed as a short-acting coronary vasodilator as an adjunct to radiotracers for use in myocardial stress imaging.

For research use only. We do not sell to patients.

Binodenoson Chemical Structure

Binodenoson Chemical Structure

CAS No. : 144348-08-3

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Description

Binodenoson (MRE-0470) is a potent and selective A2A adenosine receptor agonist (KD=270 nM). Binodenoson is being developed as a short-acting coronary vasodilator as an adjunct to radiotracers for use in myocardial stress imaging[1].

In Vitro

Binodenoson (MRE-0470) (30-300 nM) decreases oxidative activity of tumor necrosis factor-α–primed FMLP-stimulated polymorphonuclear leukocytes in human whole blood and acts synergistically with Rolipram[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Binodenoson (infused 0-0.9 μg/kg/h; adult Wistar rat; rat bacterial meningitis model), with or without rolipram (0-0.01 μg/kg/h), inhibits pleocytosis and reduces the lipopolysaccharide-induced increase in blood-brain barrier permeability (BBBP), indicative of decreased neutrophil-induced damage[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

391.42

Formula

C₁₇H₂₅N₇O₄

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Binodenoson
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