Aldehyde Dehydrogenase (ALDH) Inhibitor

CM-39 is a non-covalent and reversible inhibitor for aldehyde dehydrogenase 1A (ALDH1A) with an IC₅₀ of 0.9 μM.

Nitrefazole (Standard) is the analytical standard of Nitrefazole. This product is intended for research and analytical applications. Nitrefazole is a 4-nitroimidazole derivative with strong and long lasting inhibition of aldehyde dehydrogenase (ALDH), an enzyme involved in the metabolism of alcohol.

Dichloro-all-trans-retinone is a selective retinaldehyde dehydrogenase (RALDH) inhibitor, with an IC₅₀ of 434.7 nM and a K_i of 194.4 nM against chicken RALDH1; an IC₅₀ of 55 nM and a K_i of 5.1 nM against chicken RALDH2; an IC₅₀ of 191.32 nM and a K_i of 64.35 nM against human RALDH2; and an IC₅₀ of 161.27 nM and a K_i of 6.74 nM against chicken RALDH3. Dichloro-all-trans-retinone inhibits the synthesis of all-trans retinoic acid (ATRA). Dichloro-all-trans-retinone is applicable to research related to form-deprivation-induced myopia.

PKM2-IN-7 (compound 34) can inhibit the interaction between PKM2 and ALDH1A3 without showing significant toxicity to normal cells. PKM2-IN-7 can be used for research in the field of tumors.

Win 18446 is an orally active testes-specific enzyme ALDH1a2 inhibitor, with an IC50 of 0.3 μM. Win 18446 reversibly inhibits spermatogenesis in many species and inhibits Retinoic acid (HY-14649) biosynthesis from Retinol (HY-B1342) within the testes.

Trimethylacetaldehyde (Pivalic aldehyde; Pivalaldehyde) is an inhibitor of E. coli betaine aldehyde dehydrogenase (ALDH) with a K_i of 4.5 mM. Trimethylacetaldehyde serves as a substrate for Drosophila melanogaster alcohol dehydrogenase (AdhS), undergoing oxidation and disproportionation reactions with the release of NADH, and also forms an inactive binary enzyme-aldehyde complex via a compulsory ordered reaction mechanism.

Antihepatotoxic agent-1 is a cerebroside present in Lycium chinense Fruits with antihepatotoxic activity. Antihepatotoxic agent-1 exerts a protective effect by blocking the release of alanine aminotransferase and sorbitol dehydrogenase from primary cultured rat hepatocytes intoxicated with carbon tetrachloride. Antihepatotoxic agent-1 can be used in studies related to liver injury.

Methyl benzyl sulfoxide is an uncompetitive inhibitor of horse liver alcohol dehydrogenase with a K_i of 5.0 mM. Methyl benzyl sulfoxide inhibits ethanol metabolism in rats.

4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenases (ALDHs) inhibitor, with a Ki of 4 nM for ALDH1. 4-Diethylaminobenzaldehyde displays potent anti-androgenic effect (IC50= 1.71μM).

Sulfiram is a very weak aldehyde dehydrogenase (ALDH) inhibitor, with an IC₅₀ value of 413 μM against Saccharomyces cerevisiae ALDH. As a photochemical precursor, Sulfiram undergoes photoconversion to form Disulfiram (HY-B0240), a potent ALDH inhibitor. Sulfiram inhibits the dimerization of the extracellular domain fragment (amino acid residues 230-624) of amyloid precursor protein (APP), alters the monomer-dimer equilibrium, induces conformational changes in the fragment, and enhances the production of sAPPα via α-cleavage of APP. Sulfiram can be used in research related to scabies and Alzheimer's disease.