1477-57-2
1477-57-2
Chemical Structure
Win 18446
- CAS. Nr.: 1477-57-2
- Formula:C12H20Cl4N2O2
- Molecular Weight:366.11
IUPAC Name: N,N'-(octane-1,8-diyl)bis(2,2-dichloroacetamide)
InChIKey: FAOMZVDZARKPFJ-UHFFFAOYSA-N
SMILES: O=C(NCCCCCCCCNC(C(Cl)Cl)=O)C(Cl)Cl
Biological Activity: Win 18446 is an orally active testes-specific enzyme ALDH1a2 inhibitor, with an IC50 of 0.3 μM. Win 18446 reversibly inhibits spermatogenesis in many species and inhibits Retinoic acid (HY-14649) biosynthesis from Retinol (HY-B1342) within the testes[1][2].
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Win 18446 | 98.94% | Win 18446 is an orally active testes-specific enzyme ALDH1a2 inhibitor, with an IC50 of 0.3 μM. Win 18446 reversibly inhibits spermatogenesis in many species and inhibits Retinoic acid (HY-14649) biosynthesis from Retinol (HY-B1342) within the testes. | ||||||||||||||||||||
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Win 18446 (Standard) | ≥98% | Win 18446 is an orally active testes-specific enzyme ALDH1a2 inhibitor, with an IC50 of 0.3 μM. Win 18446 reversibly inhibits spermatogenesis in many species and inhibits Retinoic acid (HY-14649) biosynthesis from Retinol (HY-B1342) within the testes. | ||||||||||||||||||||
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References
- [1]. John K Amory, et al. Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis. J Androl. Jan-Feb 2011;32(1):111-9. [Content Brief]
- [2]. Cathryn A Hogarth, et al. Suppression of Stra8 expression in the mouse gonad by WIN 18,446. Biol Reprod. 2011 May;84(5):957-65. [Content Brief]
