Bacterial Inhibitor

Kirrothricin has antibacterial action, but no activity to subtilis, E.coli and fungi.

4(3H) -quinazolinone is a fused nitrogen heterocyclic compound whose derivatives have a wide range of antimicrobial and antitumor activities.

Ethoxzolamide-d₅ (Redupresin-d₅) is deuterium labeled Ethoxzolamide. Ethoxzolamide is a carbonic anhydrase inhibitor with K_i of 1 nM.

Cladospolide B is found in the strain of Cladosporium sp. FT-0012. Cladospolide B has little antibacterial activity.

Phenylpropiolic acid (Standard) is the analytical standard of Phenylpropiolic acid (HY-W007319). This product is intended for research and analytical applications. Phenylpropiolic acid is an Antibacterial agent. Phenylpropiolic acid is identified from the intracellular extract of Proteus mirabilis DMTMMR-11. Phenylpropiolic acid disrupts biofilm formation by reducing pathogen adhesion and enhancing biofilm clearance ability. Phenylpropiolic acid inhibits the growth of Yersinia enterocolitica, disrupts its cell membrane integrity, and increases the survival rate of infected Caenorhabditis elegans. Phenylpropiolic acid can be used in studies related to yersiniosis and gastroenteritis.

MptpB-IN-3 is a selective inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) with an IC₅₀ of 0.19 μM. MptpB-IN-3 blocks MptpB-mediated inhibition of the macrophage MAPK pathway and restores the phosphorylation levels of Erk1/2 and p38. MptpB-IN-3 exhibits direct anti-tuberculosis activity against Mycobacterium tuberculosis and reduces the Mycobacterium tuberculosis load in mouse macrophages. MptpB-IN-3 can be used for tuberculosis research.

Albiducin A is an antibiotic found in Hymenoscyphus albidus, exhibiting antibacterial and anticancer activities. The MIC range of Albiducin A against bacteria and fungi is 16.7-66.7 mg/mL. Its IC₅₀ values for mouse fibroblast cell line (L929) and human cervical carcinoma cell line (KB3-1) are 6.1 and 2.7 μg/mL, respectively. Albiducin A holds promise for research in the fields of infection and cancer diseases.

6-Amino-5-azacytidine (Standard) is the analytical standard of 6-Amino-5-azacytidine (HY-111643). This product is intended for research and analytical applications. 6-Amino-5-azacytidine inhibits the growth of bacteria E. coli.

Napyradiomycin B2 is an antibiotic with anti-Gram-positive bacteria and mycobacterial activity. Napyradiomycin B2 almost none to Gram-negative bacteria and fungi.

2-C-Methyl-D-erythritol 4-phosphate is a metabolite intermediate exclusive to the non-mevalonate MEP pathway, predominantly found in prokaryotes, serving as a precursor for the synthesis of isoprenoids and non-isoprenoids, including vitamins; its absence in humans makes it a promising target for the development of bacterium-specific drugs aimed at treating infectious diseases.

Sannamycin G (Istamycin X0) is an aminoglycoside antibiotic and has only weak antibacterial activity against a few bacteria.

Parvodicin C4 is a glycopeptide antibiotic. Parvodicin C4 has inhibitory effect on Staphylococcus aureus, Staphylococcus furfur, Staphylococcus hemolyticus and Enterococcus faecalis.

InhA-IN-11 is a Mycobacterium tuberculosis InhA inhibitor with an IC₅₀ of 0.36 μM. InhA-IN-11 exhibits activity against Mycobacterium tuberculosis, disrupts pre-formed Mycobacterium tuberculosis biofilms, and reduces bacterial viability within biofilms. InhA-IN-11 is applicable for the research of tuberculosis.

3,4,5-Trimethoxybenzoic acid (Eudesmic acid;Trimethylgallic Acid) is a benzoic acid derivative. A building block in medicine and organic synthesis. 3,4,5-Trimethoxybenzoic acid exhibits antibacterial activity against S. aureus with MIC of 0.97 μg/mL.

Kuwanon G (Standard) is the analytical standard of Kuwanon G (HY-N4247). This product is intended for research and analytical applications. Kuwanon G is a flavonoid compound and an antagonist of the bombesin receptor. Kuwanon G has multiple activities such as bactericidal, anti-tumor, anti-inflammatory, antioxidant, anti-atherosclerotic, and neuroprotective effects. Kuwanon G exhibits strong antibacterial activity against oral pathogens, especially cariogenic bacteria and periodontal pathogens. Kuwanon G can induce apoptosis and inhibit proliferation, migration, and invasion of tumor cells. Kuwanon G can be used in the research of diseases such as gastric cancer and atherosclerosis.

Florfenicol-propanoate-piperidin (Compound 1) is the derivative of Florfenicol (HY-B1374). Florfenicol-propanoate-piperidin exhibits antibacterial activity, inhibits E. coli ATCC25922, Salmonella CICC110420, S. aureus ATCC29213, B. subtilis CMCC(B)63501, E. faecalis ATCC29212, S. suis CVCC606, and Haemophilus parasuis with MIC of 2-8 μM.

Sulfanilamide (Standard) is the analytical standard of Sulfanilamide. This product is intended for research and analytical applications. ulfanilamide (Sulphanilamide) is a potent and orally active sulfonamide antibiotic and can be a major intermediate of sulfamethoxazole biodegradation. Sulfanilamide also is a carbonic anhydrase inhibitor. Sulfanilamide shows inhibition on virus of lymphogranuloma venereum.

11-Deoxy-13-deoxodaunorubicin is an anthracycline antibiotic with anti-Gram-positive bacteria, negative bacteria and tumor activity.

Ferensimycin B is a polyether antibiotic with anti-Gram-positive bacteria and weak anti-Gram-negative bacteria, fungi and coccidia.

Succinylsulfathiazole (Standard) (Succinylsulphathiazole) is the analytical standard of Succinylsulfathiazole (HY-B0921). This product is intended for research and analytical applications. Succinylsulfathiazole is a long-acting sulfonamide antibiotic with localized gut-specific antibacterial activity and is orally active. Succinylsulfathiazole inhibits bacterial folate synthesis, reduces coliform counts, suppresses intestinal bacterial growth and vitamin biosynthesis, and depletes gut folate-producing bacteria. Succinylsulfathiazole modulates hepatic mTOR signaling, diminishes cecal fermentation, decreases hepatic folate levels and total folate excretion, elevates nitrogen excretion and reduces the fermentability of certain dietary fibers. Succinylsulfathiazole induces folate deficiency and triggers biotin- and folate-related nutritional deficiency symptoms in rats and C57BL/6 mice.