COX
Cyclooxygenase
Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. Pharmacological inhibition of COX can provide relief from the symptoms of inflammation and pain. Drugs, like Aspirin, that inhibit cyclooxygenase activity have been available to the public for about 100 years. Two cyclooxygenase isoforms have been identified and are referred to as COX-1 and COX-2. Under many circumstances the COX-1 enzyme is produced constitutively (i.e., gastric mucosa) whereas COX-2 is inducible (i.e., sites of inflammation). Non-steroidal anti-inflammatory drugs (NSAID), such as aspirin and ibuprofen, exert their effects through inhibition of COX. The main COX inhibitors are the non-steroidal anti-inflammatory drugs (NSAIDs).
COX Isoform Specific Products
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Productos relacionados con COX (1315)
Productos relacionados con (1315)
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Antibodies (6)
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COX Isoform Comparison
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iNOS/COX-2-IN-3
0 ImagesReferencia número: HY-159564iNOS/COX-2-IN-3 (compound 7d) is a dual inhibitor of iNOS and COX-2, with potential anti-inflammatory activity against LPS (HY-D1056)-induced RAW 264.7 cells (IC50=3.48 μM). iNOS/COX-2-IN-3 has good plasma stability, oral activity and gastric safety, and its inhibitory activity on iNOS and COX-2 expression is 5.43-fold and 2.37-fold that of Indomethacin (HY-14397), respectively.
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Etoricoxib (Standard)
0 ImagesSynonyms: MK-0663 (Standard); L-791456 (Standard)Etoricoxib (Standard) is the analytical standard of Etoricoxib. This product is intended for research and analytical applications. Etoricoxib (MK-0663) is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.
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COX-2-IN-48
0 ImagesReferencia número: HY-168070COX-2-IN-48 (5-25), a COX-2 inhibitor with an IC50 of 51.7 nM for human COX-2, exerts anti-inflammatory and analgesic effects in various rodent models by inhibiting NF-κB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IκB, the phosphorylation and nuclear translocation of NF-κB p65, and the expression of COX-2 and iNOS.
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Mycosporine glycine
0 ImagesReferencia número: HY-N12630No. CAS: 65318-21-0Synonyms: Mycosporine-GlyMycosporine glycine (Mycosporine-Gly) is a mycosporine-like amino acid derived from marine organisms, which possesses free radical scavenging, antioxidant, anti-inflammatory and photoprotective activities. Mycosporine glycine inhibits the UV-induced upregulation of COX-2 mRNA and gene expression levels, scavenges free radicals, ROS and peroxyl radicals, and inhibits free radical chain lipid peroxidation and phosphatidylcholine peroxidation. Mycosporine glycine restores PCOLCE and elastin levels suppressed by ultraviolet radiation, alleviates photooxidative stress and UV-mediated skin cell damage. Mycosporine glycine can be used in studies related to UV-induced skin inflammation, skin photoaging and skin damage.
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Antrafenine dihydrochloride
0 ImagesReferencia número: HY-119912No. CAS: 55300-30-6Synonyms: Stakane dihydrochlorideAntrafenine (Stakane) dihydrochloride is a non-narcotic analgesic. Antrafenine dihydrochloride demonstrates central analgesic effects in acetic acid writhing test and mouse hot plate test experiments. Antrafenine dihydrochloride significantly alleviates osteoarthritis pain. Antrafenine dihydrochloride exhibits mild anti-inflammatory activity in a rat toe edema model. Antrafenine dihydrochloride can be used for pain and anti-inflammatory research.
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COX-2-IN-30
0 ImagesReferencia número: HY-149269No. CAS: 1160498-08-7COX-2-IN-30 is a benzenesulfonamide derivative, as well as an orally active and dual inhibitor of COX (IC50=49 nM for COX-2, 10.4 μM for COX-1) and 5-LOX (IC50=2.4 μM). COX-2-IN-30 also inhibits transmembrane hCA IX and hCA XII isoform with nanomolar calss Ki values. COX-2-IN-30 exhibits analgesic, anti-inflammatory, and ulcerogenic activities, and does not show acute gastric effect.
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P-8977
0 ImagesReferencia número: HY-108109No. CAS: 135810-00-3P-8977 is a potent dual CO/5-LO inhibitor (IC50 = 0.01 µM). P-8977 can also inhibit cyclooxygenase (CO) (IC50 = 0.53 µM) in 3T3 cells. P-8977 can inhibit ear edema. P-8977 can be used for research on inflammatory skin conditions.
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Psoralidin (Standard)
0 ImagesPsoralidin (Standard) is the analytical standard of Psoralidin. This product is intended for research and analytical applications. Psoralidin is a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties. Psoralidin significantly downregulates NOTCH1 signaling. Psoralidin also greatly induces ROS generation.
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Picfeltarraenin IA (Standard)
0 ImagesReferencia número: HY-N1474RNo. CAS: 97230-47-2Picfeltarraenin IA (Standard) is the analytical standard of Picfeltarraenin IA (HY-N1474). This product is intended for research and analytical applications. Picfeltarraenin IA is an Acetylcholinesterase inhibitor. Picfeltarraenin IA can be extracted from the plant Picria fel-terrae Lour. Picfeltarraenin IA reduces the production of IL-8 and PGE2. Picfeltarraenin IA inhibits COX2 via the NF-κB pathway. Picfeltarraenin IA can be used in the research of respiratory system diseases.
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LYRM03
0 ImagesReferencia número: HY-N19847No. CAS: 1820750-36-4LYRM03 is a derivative of Ubenimex (HY-B0134) and a Aminopeptidase N inhibitor. LYRM03 is isolated from Streptomyces HCCB10043. LYRM03 inhibits TLR4, MyD88, NLRP3, ASC, NF-κB and p38 MAPK, stabilizes IκB, and suppresses LPS-induced expression of iNOS and COX-2. LYRM03 reduces the levels of inflammatory cytokines and oxidative stress markers, and alleviates pulmonary edema. LYRM03 exhibits anticancer activity against breast cancer. LYRM03 has anti-inflammatory activity. LYRM03 can be used in the research of acute lung injury and breast cancer.
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cis-5-Dodecenoic acid (Standard)
0 Imagescis-5-Dodecenoic acid (Standard) is the analytical standard of cis-5-Dodecenoic acid (HY-N8469). This product is intended for research and analytical applications. cis-5-Dodecenoic acid is an inhibitor of COX-I and COX-II with anti-inflammatory activity. cis-5-Dodecenoic acid reduces prostaglandin synthesis by inhibiting COX enzyme activity and is involved in the fatty acid -β oxidative metabolic pathway. The metabolic rate of cis-5-Dodecenoic acid is significantly lower than that of saturated fatty acids. cis-5-Dodecenoic acid can be used in the research of anti-inflammation, fatty acid metabolism mechanisms and related physiological and pathological processes.
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COX-2-IN-11
0 ImagesReferencia número: HY-145988No. CAS: 1023741-06-1COX-2-IN-11 (compound 7b2) is a potent and selective inhibitor of COX-2. COX-2-IN-11 has the potential for the research of inflammation diseases.
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Magnesium sulfate heptahydrate, for molecular biology
0 ImagesReferencia número: HY-W094477DNo. CAS: 10034-99-8Synonyms: Epsom salts, for molecular biologyMagnesium sulfate heptahydrate (for molecular biology) is a molecular biology-grade form of Magnesium sulfate (HY-Y1267). Magnesium sulfate is a calcium antagonist and a potent L-type calcium channel inhibitor, as well as a uterine contraction inhibitor. Magnesium sulfate has anti-inflammatory, anticonvulsant, vasodilatory, and neuroprotective effects. Magnesium sulfate can be used in research on diseases such as preeclampsia/eclampsia.
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DL-1′-Acetoxychavicol acetate
0 ImagesDL-1′-Acetoxychavicol acetate is a compound with anti-inflammatory and anticancer preventive potential that inhibits the activities of NOX, iNOS, and COX-2 in inflammatory cells and exhibits preventive activity in multiple inflammation-related cancer models.
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Oxaprozin potassium
0 ImagesReferencia número: HY-B0808ANo. CAS: 174064-08-5Synonyms: Oxaprozinum potassium; Wy21743 potassiumOxaprozin potassium is an orally active and potent COX inhibitor, with IC50 values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin potassium also inhibits the activation of NF-κB. Oxaprozin potassium induces cell apoptosis. Oxaprozin potassium shows anti-inflammatory activity. Oxaprozin potassium-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties.
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Prostaglandin F1a-d9
0 ImagesReferencia número: HY-113459SNo. CAS: 1542166-81-3Prostaglandin F1a-d9 is the deuterium labeled Prostaglandin F1a. Prostaglandin F1a is an endogenous metabolite and a cyclooxygenase product with platelet activity inhibitory effects. Prostaglandin F1a can be used as a marker in coagulation-related studies.
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COX-2/15-LOX-IN-4
0 ImagesReferencia número: HY-155161No. CAS: 3052736-45-2COX-2/15-LOX-IN-4 (compound 5i) is a dual inhibitor of COX-2/15-LOX with IC50s of 0.075 μM and 1.97 μM, respectively. COX-2/15-LOX-IN-4 can inhibit LPS-induced cell production of promoting cytokines (IL-6, ROS) with specific anti-inflammatory activity.
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Itazigrel
0 ImagesReferencia número: HY-106046No. CAS: 70529-35-0Synonyms: U-53059Itazigrel (U-53059) is an orally active antiplatelet agent. Itazigrel inhibits cyclooxygenase activity. Itazigrel inhibits platelet aggregation.
