Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
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Fungal Related Products (2768)
Related Products (2768)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Orsellinic acid (Standard)
0 ImagesOrsellinic acid (Standard) is an analytical standard of Orsellinic acid (HY-N3126). This product is intended for research and analytical applications. Orsellinic acid is a Benzoic acid (HY-N0216) derivative. Orsellinic acid can be isolated from Chaetomium globosum endophytic on Ephedra fasciculata (Mormon tea). Orsellinic acid blocks PAF-mediated Apoptosis, inhibits caspase-3/7 activation, and PARP cleavage. Orsellinic acid can be used in research of neurons and various tumors (non-small cell lung cancer, breast cancer, neuroblastoma, pancreatic cancer).
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Crocacin D
0 ImagesCat. No.: HY-N14044CAS No.: 237425-39-7
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Ezomycin A2
0 ImagesCat. No.: HY-N14269CAS No.: 54328-22-2Ezomycin A2 is an antifungal antibiotic. Ezomycin A2 is mainly active against phytopathogens such as Sclerotinia sclerotiorum and Botrytis, and has a control effect on Sclerotinia, Botrytis and Candidiasis of crops.
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Chainin
0 ImagesCat. No.: HY-N15056CAS No.: 38264-25-4Chainin has anti-yeast and Aspergillus Niger fungal activity.
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Antifungal agent 107
0 ImagesCat. No.: HY-163891CAS No.: 2684411-12-7Antifungal agent 107 (compound b24) is an OSBP inhibitor with antifungal activity. Antifungal agent 107 can be used to control cucumber downy mildew and potato late blight in greenhouse.
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Rilopirox
0 ImagesCat. No.: HY-113863CAS No.: 104153-37-9Synonyms: HOE 351Rilopirox (HOE 351) is a hydroxy-pyridone compound with antimycotic properties. Rilopirox, a chelating agent, can inhibit catalase. Rilopirox inhibits the respiratory chain. Rilopirox inhibits growth of yeast isolates with a MIC50 of 4 μg/mL. Rilopirox has the potential for vaginal candidosis and oropharyngeal Candida infections research.
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Cavipetin C
0 ImagesCat. No.: HY-N15288CAS No.: 128552-90-9Cavipetin C is a diterpene that can be isolated from B. cavipes. Cavipetin C exhibits antifungal activity that blocks the Cladosporium cucumericum spore formation.
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Ammonium bicarbonate-15N
0 ImagesCat. No.: HY-W093399SAmmonium bicarbonate-15N is the 15N labeled isotope of Ammonium bicarbonate,AR,99% (HY-W093399). Ammonium bicarbonate,AR,99% is an analytical reagent-grade ammonium bicarbonate. Ammonium bicarbonate has antifungal activity. Ammonium bicarbonate is widely used in laboratory analysis, food processing, agricultural fertilization and other fields.
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Phenylmercuriurea
0 ImagesPhenylmercuriurea is an organomercurial fungicide. Phenylmercuriurea exerts antifungal and antibacterial effects by inhibiting the activity of key enzymes via the binding of mercury ions to sulfhydryl groups of microbial proteins. Phenylmercuriurea can be used in studies related to infections caused by phytopathogenic fungi and bacteria.
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Tenellin
0 ImagesCat. No.: HY-138035CAS No.: 53823-15-7Tenellin is a fungal metabolite that has been found in Beauveria. It inhibits Mg2+-, Ca2+-, and Na+/K+-ATPase activities in equine erythrocytes by 51, 57, and 74%, respectively, when used at a concentration of 200 μg/mL.1 Tenellin is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of- 4.84 and 11.95 μM, respectively.
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Dunaimycin A1
0 ImagesCat. No.: HY-N14737CAS No.: 140221-72-3Dunaimycin A1 is a 24-membered macrolide compound with immunosuppressive activity and antifungal activity against Aspergillus niger. Dunaimycin A1 is promising for research of autoimmune diseases.
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Pradimicin Tl
0 ImagesCat. No.: HY-N14436CAS No.: 149598-64-1Pradimicin T1 is an antibiotic. Pradimicin Tl has activity against filamentous fungi and yeast-like fungi.
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Chandrananimycin B
0 ImagesCat. No.: HY-N14604CAS No.: 664355-13-9Chandrananimycin B has anti-mucor activity, as well as anti-tumor cell activity such as CCL HT29, MFXF 529L, MACL McF-7.
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(Rac)-Sativan
0 ImagesCat. No.: HY-122448ACAS No.: 71831-00-0(Rac)-Sativan is an isoflavanoid with a broad spectrum of antimicrobial activity against bacteria and phytopathogenic fungi. (Rac)-Sativan exhibits antituberculosis activity against Mycobacterium tuberculosis H37Rv, with MIC values of 50 µg/mL.
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Penflufen (Standard)
0 ImagesCat. No.: HY-139161RCAS No.: 494793-67-8Penflufen (Standard) is the analytical standard of Penflufen. This product is intended for research and analytical applications. Penflufen is a highly efficient, broad-spectrum succinate dehydrogenase inhibitor (SDHI). Penflufen can be used as a fungicide and has broad bioactivity against many fungal diseases, including potato black scurf, wheat sharp eyespot, rice sheath blight, and root rot in peanut and other similar fungal diseases.
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NC-1175 hydrochloride
0 ImagesCat. No.: HY-107772CAS No.: 214834-79-4NC-1175 hydrochloride is an antifungal agent targeting cell membrane H+-ATPase. NC-1175 hydrochloride can be used for the research of infection.
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5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol
0 Images5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol (Compound 3n) is an antimicrobial and antioxidant agent, that inhibits Escherichia coli and Staphylococcus epidermidis, with MIC of 8 and 4 μg/mL. 5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol exhibits antioxidant activity with IC50 of 17.47 μM using DPPH free radical-scavenging method.
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Antibacterial agent 229
0 ImagesCat. No.: HY-161813CAS No.: 3049500-54-8Antibacterial agent 229 (compound 8a) is a potent antibacterial agent. Antibacterial agent 229 shows antibacterial and antifungal abilities. Antibacterial agent 229 disrupts the integrity of the bacterial membrane, intercalates into DNA. Antibacterial agent 229 inhibits topoisomerase IV with an IC50 value of 10.88 µM.
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Cs-2d
0 ImagesCat. No.: HY-175198CAS No.: 2928129-57-9Cs-2d is a selective ceramide synthases Cer1 inhibitor. Cs-2d has potent inhibitory activity toward C. neoformans Cer1, while maintaining a low off-target effect on human hCerS1. Cs-2d has potent antifungal activity with the significant growth inhibition. Cs-2d can be used for invasive fungal infections research.
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SDH-IN-35
0 ImagesCat. No.: HY-178469SDH-IN-35 (Compound A17) is a potent succinate dehydrogenase (SDH) inhibitor with antifungal activity (EC50=11.9 μM). SDH-IN-35 is promising for research of agricultural fungicide.
