Influenza Virus
Influenza virus belongs to the Orthomyxoviridae group, which are enveloped, segmented, single-stranded negative sense RNA viruses. The group includes three types of influenza viruses, A, B and C. Type B and C viruses only infect humans, but the type A viruses infect humans, horses, swine, other mammals, and a wide variety of domesticated and wild birds. Human influenza A and B viruses cause seasonal epidemics of disease almost every winter in the United States. The emergence of a new and very different influenza virus to infect people can cause an influenza pandemic. Influenza type C infections cause a mild respiratory illness and are not thought to cause epidemics. Each virus subtype has mutated into a variety of strains with differing pathogenic profiles; some are pathogenic to one species but not others, some are pathogenic to multiple species.
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Influenza Virus Related Products (728)
Related Products (728)
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Recombinant Proteins (585)
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Antibodies (1)
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(E/Z)-RA-0002034
0 ImagesCat. No.: HY-161762ACAS No.: 2305572-22-7Synonyms: (E/Z)-RA-2034
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VIR-2482
0 ImagesCat. No.: HY-P992482VIR-2482 is a monoclonal antibody targeting influenza A hemagglutinin (HA). VIR-2482 is generated by introducing LS mutations (M428L/N434S) into the Fc region of MEDI8852 (HY-P991446). VIR-2482 binds to the conserved HA stem epitope across all 18 influenza A HA subtypes, neutralizes a broad spectrum of H1N1 and H3N2 strains, binds to FcγRIIIa, FcγRIIa and C1q, and induces antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity. VIR-2482 reduces morbidity and mortality caused by seasonal influenza A strains and provides prophylactic protection in mice. VIR-2482 can be used in research related to influenza A disease.
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Cap-dependent endonuclease-IN-2
0 ImagesCat. No.: HY-143743CAS No.: 2303917-78-2Cap-dependent endonuclease-IN-2 is a potent inhibitor of cap-dependent endonuclease (CEN). Not only can Cap-dependent endonuclease-IN-2 inhibit influenza virus well, but also has lower cytotoxicity, better in vivo agent kinetic properties and in vivo pharmacodynamic properties. Cap-dependent endonuclease-IN-2 has strong inhibitory effect on RNA polymerase activity of A virus (extracted from patent WO2019052565A1, compound 28).
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Influenza virus-IN-7
0 ImagesCat. No.: HY-153570CAS No.: 2703046-92-6Influenza virus-IN-7 (Example 16) is an orally active cap-dependent endonuclease inhibitor that can be used for the research of influenza viral infectious diseases.
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Baloxavir marboxil-d1
0 ImagesCat. No.: HY-109025S2CAS No.: 2246959-10-2Synonyms: S-033188-d1; RG 6152-d1Baloxavir marboxil-d1 (S-033188-d1) is the d1-labeled Baloxavir marboxil (HY-109025). Baloxavir marboxil (S-033188) is a selective inhibitor of influenza cap-dependent endonuclease. Baloxavir marboxil, a potent antiviral agent, shows activity against influenza A and B virus.
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ATV03
0 ImagesCat. No.: HY-168510ATV03 is an anti-influenza virus agent with excellent anti-influenza A and B virus activity. ATV03 inhibits anti-influenza A (H3N2) and anti-influenza B with EC50 values of 0.78 nM and 2.02 nM, respectively. ATV03 exerts anti-influenza activity by inhibiting polymerase acidic protein (PA) and RNA-dependent RNA polymerase (RdRp), as well as disrupting nuclear protein.
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Anti-Influenza agent 12
0 ImagesCat. No.: HY-189215CAS No.: 3087067-85-1Anti-Influenza agent 12 is an orally active inhibitor of influenza A virus infection. Anti-Influenza agent 12 inhibits RIG-I-mediated innate immune signaling and TLR3-mediated signaling pathways. Anti-Influenza agent 12 inhibits NF-κB phosphorylation and downregulates the expression levels of IRF3, ASC, iNOS, IL-4, IL-6, and IFN-α inflammatory genes. Anti-Influenza agent 12 inhibits viral nucleoprotein (NP) and matrix protein 2 (M2) mRNA transcription and protein synthesis. Anti-Influenza agent 12 inhibits virus-induced apoptosis, reduces ROS and NO production, and maintains mitochondrial membrane potential. Anti-Influenza agent 12 exhibits broad-spectrum activity against H1N1 and H3N2 subtypes, reduces viral load, and alleviates lung tissue damage. Anti-Influenza agent 12 can be used for research on influenza A virus infection.
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Neuraminidase-IN-12
0 ImagesCat. No.: HY-149057CAS No.: 2218480-15-8NDV-IN-1 is an antiviral agent with high neuraminidase inhibitory activity. NDV-IN-1 exhibits in vitro inhibitory activity against Newcastle disease virus (NDV). NDV-IN-1 significantly inhibits NDV infection of Vero cells by preventing the release of virus particles from infected cells. Neuraminidase-IN-12 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Ketotifen (Standard)
0 ImagesCat. No.: HY-B0157RCAS No.: 34580-13-7Synonyms: HC 20-511 (Standard)Ketotifen (Standard) is the analytical standard of Ketotifen. This product is intended for research and analytical applications. Ketotifen (HC 20-511) is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention.
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Cap-dependent endonuclease-IN-5
0 ImagesCat. No.: HY-143747CAS No.: 2416258-53-0Cap-dependent endonuclease-IN-5 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-5 inhibits influenza virus well, and/or has lower cytotoxicity, better in vivo pharmacokinetic properties and in vivo pharmacodynamic properties (extracted from patent WO2020078401A1, compound 13-1).
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Cap-dependent endonuclease-IN-16
0 ImagesCat. No.: HY-143770CAS No.: 2643370-92-5Cap-dependent endonuclease-IN-16 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-16 is a pyridone polycyclic derivative. Cap-dependent endonuclease-IN-16 has the potential for the research of influenza (extracted from patent CN112778330A, compound 15A).
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1,4-Epidioxybisabola-2,10-dien-9-one
0 ImagesCat. No.: HY-N9019CAS No.: 170380-69-51,4-Epidioxybisabola-2,10-dien-9-one is a 1,4-epidioxy-bisabola-2,12-diene derivate, which can be isolated from Curcuma longa L. 1,4-Epidioxybisabola-2,10-dien-9-one exhibits antiviral activity against influenza virus A/PR/8/34 (H1N1) in the MDCK cell line with an IC50 of 16.79 ± 4.03 μg/mL.
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Cap-dependent endonuclease-IN-21
0 ImagesCat. No.: HY-144066CAS No.: 2741952-35-0Cap-dependent endonuclease-IN-21 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-21 inhibits the replication of influenza virus. ap-dependent endonuclease-IN-21 has the potential for the research of influenza virus infection (influenza A) (extracted from patent WO2021233302A1, compound 8B or 8A).
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Cap-dependent endonuclease-IN-12
0 ImagesCat. No.: HY-143762CAS No.: 2460686-97-7Cap-dependent endonuclease-IN-12 (EXP-35) is a potent Cap-dependent endonuclease inhibitor with low cytotoxicity. Cap-dependent endonuclease-IN-12 shows inhibitory activity against H1N1.
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Antiviral agent 68
0 ImagesCat. No.: HY-N15618CAS No.: 87095-75-8Antiviral agent 68 (Compound 3) is a diarylheptanoid that can be isolated from Alpinia katsumadai. Antiviral agent 68 has weak inhibitory activity against the neuraminidase of influenza virus A/PR/8/34, with an IC50 of 29.75 μM.
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VF-57a
0 ImagesCat. No.: HY-175808VF-57a (Compound 23) is an Influenza A virus (IAV) fusion inhibitor. VF-57 has potent antiviral activities against authentic A/H1N1 virus with EC50s of 0.92 and 0.31 μM for the A/H1N1 PR8 and A/H1N1 Virg09 strains, respectively. VF-57 significantly inhibits HA-mediated cell entry of A/H1N1- and A/H5N1-pseudoviruses, prevents the HA refolding at pH 5.2. VF-57a can be used for IAV infections research.
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Neuraminidase-IN-10
0 ImagesCat. No.: HY-151103CAS No.: 2685786-29-0Neuraminidase-IN-10 is a potent neuraminidase (NA) inhibitor with anti-influenza activity. Neuraminidase-IN-10 is against H1N1, H5N1, and H5N8 with IC50 values of 2.6 nM, 5.1 nM, and 1.65 nM, respectively.
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RSV-IN-3
0 ImagesCat. No.: HY-143495CAS No.: 862825-90-9RSV-IN-3 (Compound 1) is a dual inhibitor of respiratory syncytial virus (RSV) and influenza virus A (IAV). RSV-IN-3 shows anti-RSV activity (EC50 = 32.70 μM).
