Integrin
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Integrin Inhibitors
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Integrin Ligands
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Integrin Related Products (380)
Related Products (380)
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MK-852
0 ImagesCat. No.: HY-P0038CAS No.: 138199-64-1Synonyms: L-367073MK-852 (L-367073) is an effective GPIIb/IIIa receptor antagonist. MK-852 can significantly inhibit the binding of fibrinogen to platelets in vitro. MK-852can be used for the study of thrombosis.
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Cyclo(Arg-Gly-Asp-D-Phe-Val)
0 ImagesCat. No.: HY-P1613CAS No.: 137813-35-5Synonyms: Cyclo(RGDfV); C(RGDfV)Cyclo(Arg-Gly-Asp-D-Phe-Val) (Cyclo(RGDfV)) is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) can be used for the research of acute myeloid leukemia.
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DSPE-PEG3000-iRGD
0 ImagesCat. No.: HY-172495DSPE-PEG3000-iRGD is a PEG compound which composed of DSPE and an αv-integrins targeting peptide (iRGD). iRGD peptide binds to αv-integrins, and then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties. DSPE-PEG3000-iRGD can be used for drug delivery.
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VPI-2690B
0 ImagesCat. No.: HY-P991254
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MOR102
0 ImagesCat. No.: HY-P992413MOR102 is a fully human IgG4 monoclonal antibody and an ICAM-1 inhibitor, lacking cross-reactivity with ICAM-2 and ICAM-3. MOR102 binds to the LFA-1 binding site within ICAM-1 domain 1, blocks ICAM-1/LFA-1 interaction, binds human keratinocytes with increased binding to interferon-γ-stimulated keratinocytes. MOR102 inhibits lymphocyte adhesion, reduces lymphocyte proliferation, prevents local T-cell activation, reduces inflammatory infiltrate, restores orthokeratotic differentiation, and reduces epidermal thickness. MOR102 can be used for the research of psoriasis.
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αMβ2 integrin agonist-1
0 ImagesCat. No.: HY-175288αMβ2 integrin agonist-1 (Compound 8) is a highly selective αMβ2 integrin agonist with anti-inflammatory activity (EC50=1.4 nM). αMβ2 integrin agonist-1 activates integrin-mediated cell adhesion and JNK/ERK signaling. αMβ2 integrin agonist-1 induces tumor-associated macrophage repolarization and enhances antitumor T-cell immune responses. αMβ2 integrin agonist-1 is promising for research of cancers and chronic inflammatory diseases (e.g., pancreatic cancer, rheumatoid arthritis).
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DSPE-PEG1000-iRGD
0 ImagesCat. No.: HY-172493DSPE-PEG1000-iRGD is a PEG compound which composed of DSPE and an αv-integrins targeting peptide (iRGD). iRGD peptide binds to αv-integrins, and then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties. DSPE-PEG1000-iRGD can be used for drug delivery.
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H-Gly-Pro-Arg-Pro-NH2
0 ImagesCat. No.: HY-P2708CAS No.: 126047-75-4H-Gly-Pro-Arg-Pro-NH2 is a peptide that mimics the N-terminal Gly-Pro-Arg region in the a chain of fibrin protein. H-Gly-Pro-Arg-Pro-NH2 prevents fibrin polymerization.
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GP1 precursor
0 ImagesCat. No.: HY-177580CAS No.: 1423134-36-4GP1 precursor has high affinity to GPIIb/IIIa receptors of activated platelets. GP1 precursor can be radiolabeled with [18F] and used as a PET Tracer for visualizing active platelet aggregation at the molecular level. GP1 precursor can be used for the detection of Thrombi.
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SPP-037
0 ImagesCat. No.: HY-172888SPP-037 is an orally active and selective inhibitor of ST6GAL1 (IC50 = 3.59 μM). SPP-037 inhibits integrin α2,6-sialylation and integrin-FAK-paxillin pathway. SPP-037 inhibits cancer cell proliferation, migration and exhibits antiangiogenic activity. SPP-037 has anti-tumor activity in MDA-MB-231 xenograft mouse model. SPP-037 can be used for the research of triple-negative breast cancer.
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NPC-15669
0 ImagesCat. No.: HY-112079CAS No.: 132684-62-9NPC-15669 is a novel Mac-1 inhibitor. NPC-15669 reduces plasma levels of ET-1, TxB, prostacyclin, AT-III, and total protein S. NPC-15669 can be used in the research of myocardial infarction.
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RGD-DA6
0 ImagesCat. No.: HY-176300CAS No.: 3105965-82-7RGD-DA6 is an αvβ3-targeted ligand. RGD-DA6 consists of RGDfK (an integrin αvβ3-targeted RGD peptide), DOTADG, d-Glu, Lys, AMBA, and IPBA. RGD-DA6 can be radiolabeled as an αvβ3-targeted radioligand and used for high-contrast tumor imaging and enhanced anticancer efficacy.
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Tris-ανβ6 integrin ligand-3
0 ImagesCat. No.: HY-185469CAS No.: 3047235-33-3
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GR144053 trihydrochloride
0 ImagesCat. No.: HY-107590CAS No.: 1215333-48-4GR 144053 trihydrochloride is a selective and non-peptic GPIIb/IIIa inhibitor (IC50=37 nM).
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Lotrafiban
0 ImagesCat. No.: HY-10314CAS No.: 171049-14-2Synonyms: SB-214857Lotrafiban is an orally-active platelet GPIIb/IIIa blocker for research of coronary and cerebrovascular disease.
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D-RGDW acetate
0 ImagesCat. No.: HY-P11384APurity: 98.83%D-RGDW acetate is an Arg-Gly-Asp (RGD) containing peptide. D-RGDW acetate inhibits αIIbβ3 mediated platelet aggregation.
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MSH-TP15e
0 ImagesCat. No.: HY-P991250MSH-TP15e is a humanized monoclonal antibody inhibitor targeting intercellular adhesion molecule-1 (ICAM-1). MSH-TP15e recruits natural killer cells and significantly triggers antibody-dependent cell-mediated cytotoxicity (ADCC) to inhibit tumor cell growth. MSH-TP15e is promising for research of multiple myeloma (MM).
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RGDSPASSKP
0 ImagesCat. No.: HY-P2635CAS No.: 91575-25-6RGDSPASSKP is a RGDS-containing fibronectin decapeptide.
