Integrin
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Integrin Inhibitors
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Integrin Agonists
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Integrin Antagonists
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Integrin Activators
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Integrin Chemicals
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Integrin Inducers
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Integrin Degrader
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Integrin Substrate
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Integrin Ligands
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Productos relacionados con Integrin (382)
Productos relacionados con (382)
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Tirofiban hydrochloride
0 ImagesReferencia número: HY-17369ANo. CAS: 142373-60-2Synonyms: L700462 hydrochloride; MK383 hydrochlorideTirofiban (L700462) hydrochloride is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist that inhibits fibrinogen binding to this receptor and has antithrombotic activity. Tirofiban hydrochloride induces proliferation and migration on endothelial cell by inducing production of VEGF. Tirofiban hydrochloride can significantly reduces myocardial no-reflow and ischemia-reperfusion injury by alleviating myocardial microvascular structural and endothelial dysfunction in the ischemic area.
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Alicaforsen sodium scrambled negative control
0 ImagesReferencia número: HY-145728DAlicaforsen sodium scrambled negative control is the sequence scrambled negative control of Alicaforsen sodium.
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Zalunfiban acetate
0 ImagesReferencia número: HY-119350CNo. CAS: 2376629-15-9Synonyms: RUC-4 acetateZalunfiban (RUC-4) acetate is a potent, selective platelet αIIbβ3antagonist (IC50=45 nM). Zalunfiban acetate can be used for the research of myocardial infarction (MI).
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Ro 43-5054
0 ImagesReferencia número: HY-125668No. CAS: 138107-58-1Ro 43-5054 is a platelet glycoprotein IIb-IIIa receptor antagonist. Ro 43-5054 can be used in the research of early reocclusion after thrombolytic therapy.
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MK-852
0 ImagesReferencia número: HY-P0038No. CAS: 138199-64-1Synonyms: L-367073MK-852 (L-367073) is an effective GPIIb/IIIa receptor antagonist. MK-852 can significantly inhibit the binding of fibrinogen to platelets in vitro. MK-852can be used for the study of thrombosis.
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Cyclo(Arg-Gly-Asp-D-Phe-Val)
0 ImagesReferencia número: HY-P1613No. CAS: 137813-35-5Synonyms: Cyclo(RGDfV); C(RGDfV)Cyclo(Arg-Gly-Asp-D-Phe-Val) (Cyclo(RGDfV)) is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) can be used for the research of acute myeloid leukemia.
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DSPE-PEG3000-iRGD
0 ImagesReferencia número: HY-172495DSPE-PEG3000-iRGD is a PEG compound which composed of DSPE and an αv-integrins targeting peptide (iRGD). iRGD peptide binds to αv-integrins, and then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties. DSPE-PEG3000-iRGD can be used for drug delivery.
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VPI-2690B
0 ImagesReferencia número: HY-P991254
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Bexotegrast hydrochloride
0 ImagesReferencia número: HY-137561ANo. CAS: 2775365-40-5Synonyms: PLN-74809 hydrochlorideBexotegrast hydrochloride (PLN-74809 hydrochloride) is a small molecule dual selective inhibitor with activity targeting αVβ1 and αVβ6. Bexotegrast hydrochloride is used for idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC). Bexotegrast hydrochloride inhibits the activation of TGF-β1 by blocking the function of these integrins, thereby preventing the growth of fibrous tissue in the lungs and bile ducts.
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MOR102
0 ImagesReferencia número: HY-P992413MOR102 is a fully human IgG4 monoclonal antibody and an ICAM-1 inhibitor, lacking cross-reactivity with ICAM-2 and ICAM-3. MOR102 binds to the LFA-1 binding site within ICAM-1 domain 1, blocks ICAM-1/LFA-1 interaction, binds human keratinocytes with increased binding to interferon-γ-stimulated keratinocytes. MOR102 inhibits lymphocyte adhesion, reduces lymphocyte proliferation, prevents local T-cell activation, reduces inflammatory infiltrate, restores orthokeratotic differentiation, and reduces epidermal thickness. MOR102 can be used for the research of psoriasis.
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αMβ2 integrin agonist-1
0 ImagesReferencia número: HY-175288αMβ2 integrin agonist-1 (Compound 8) is a highly selective αMβ2 integrin agonist with anti-inflammatory activity (EC50=1.4 nM). αMβ2 integrin agonist-1 activates integrin-mediated cell adhesion and JNK/ERK signaling. αMβ2 integrin agonist-1 induces tumor-associated macrophage repolarization and enhances antitumor T-cell immune responses. αMβ2 integrin agonist-1 is promising for research of cancers and chronic inflammatory diseases (e.g., pancreatic cancer, rheumatoid arthritis).
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DSPE-PEG1000-iRGD
0 ImagesReferencia número: HY-172493DSPE-PEG1000-iRGD is a PEG compound which composed of DSPE and an αv-integrins targeting peptide (iRGD). iRGD peptide binds to αv-integrins, and then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties. DSPE-PEG1000-iRGD can be used for drug delivery.
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H-Gly-Pro-Arg-Pro-NH2
0 ImagesReferencia número: HY-P2708No. CAS: 126047-75-4H-Gly-Pro-Arg-Pro-NH2 is a peptide that mimics the N-terminal Gly-Pro-Arg region in the a chain of fibrin protein. H-Gly-Pro-Arg-Pro-NH2 prevents fibrin polymerization.
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GP1 precursor
0 ImagesReferencia número: HY-177580No. CAS: 1423134-36-4GP1 precursor has high affinity to GPIIb/IIIa receptors of activated platelets. GP1 precursor can be radiolabeled with [18F] and used as a PET Tracer for visualizing active platelet aggregation at the molecular level. GP1 precursor can be used for the detection of Thrombi.
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Relitegatide
0 ImagesReferencia número: HY-P11708No. CAS: 2708163-13-5
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SPP-037
0 ImagesReferencia número: HY-172888SPP-037 is an orally active and selective inhibitor of ST6GAL1 (IC50 = 3.59 μM). SPP-037 inhibits integrin α2,6-sialylation and integrin-FAK-paxillin pathway. SPP-037 inhibits cancer cell proliferation, migration and exhibits antiangiogenic activity. SPP-037 has anti-tumor activity in MDA-MB-231 xenograft mouse model. SPP-037 can be used for the research of triple-negative breast cancer.
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NPC-15669
0 ImagesReferencia número: HY-112079No. CAS: 132684-62-9NPC-15669 is a novel Mac-1 inhibitor. NPC-15669 reduces plasma levels of ET-1, TxB, prostacyclin, AT-III, and total protein S. NPC-15669 can be used in the research of myocardial infarction.
