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Integrin Ligands
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Integrin Related Products (383)
Related Products (383)
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Osteoprotegerin
0 ImagesCat. No.: HY-183516CAS No.: 19220-35-0Synonyms: OPGOsteoprotegerin (OPG) belongs to the tumor necrosis factor receptor (TNFR) superfamily. Osteoprotegerin blocks the RANKL-RANK interaction as well as the binding of TRAIL to its receptor. Osteoprotegerin activates NF-κB to induce the expression of ICAM-1, VCAM-1 and E-selectin, and activates the phosphorylation of ERK1/2. Osteoprotegerin regulates osteoclast activity, inhibits osteoclast maturation and formation, bone lysis and bone resorption, and increases bone mass. Osteoprotegerin regulates vascular endothelial cell function. Osteoprotegerin can be used in the research of cardio-cerebrovascular and bone-related diseases.
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Des-ethyl-carafiban
0 ImagesCat. No.: HY-169836CAS No.: 170565-45-4Des-ethyl-carafiban (Compound 44) is a fibrinogen receptor antagonist that can effectively inhibit platelet aggregation induced by multiple agonists. Des-ethyl-carafiban can be used in the research of thrombotic diseases.
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Lifitegrast-d4-1
0 ImagesCat. No.: HY-19344S2Lifitegrast-d4-1 is deuterium labeled Lifitegrast. Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast can be used for researching dry eye disease.
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BTT-3033 (Standard)
0 ImagesCat. No.: HY-110112RCAS No.: 1259028-99-3BTT-3033 (Standard) is the analytical standard of BTT-3033 (HY-110112). This product is intended for research and analytical applications. BTT-3033 is an orally active conformation-selective inhibitor of α2β1 (EC50: 130 nM) by binding to the α2I domain. BTT-3033 inhibits platelet binding to collagen I and cell proliferation, and induces cell apoptosis. BTT-3033 can be used in the research of prostate cancer, inflammation and cardiovascular disease.
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Certepetide-13C6,15N2
0 ImagesCat. No.: HY-P3448SSynonyms: CEND-1-13C6,15N2; iRGD-13C6,15N2; LSTA1-13C6,15N2Certepetide-13C6,15N2 (CEND-1-13C6,15N2) is the 13C- and 15N-labeled Certepetide (HY-P3448). Certepetide (CEND-1) is a bifunctional cyclic peptide (a.k.a. iRGD). Certepetide is a tumor-penetrating enhancer via RGD motif interaction with alphav-integrins and via activating NRP-1, and transforms the solid tumor microenvironment into a temporary agent conduit. Certepetide accumulates in tumors, and is used in the research of pancreatic cancer and other solid tumors.
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Fuzapladib potassium
0 ImagesCat. No.: HY-19151BCAS No.: 141284-74-4Synonyms: IS-741 potassiumFuzapladib (IS-741) potassium, an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule. Fuzapladib potassium is also a phospholipase A2 (PLA2) inhibitor. Fuzapladib potassium exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site.
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RUC-1
0 ImagesCat. No.: HY-124499CAS No.: 796886-30-1RUC-1 (Compound 1) is an inhibitor for αIIbβ3 integrin. RUC-1 inhibits fibrin deposition and platelet aggregation in hybrid hαIIb/mβ3 receptors expressing mice. RUC-1 exhibits antithrombotic effect in hαIIb/mβ3 receptor expressing mice.
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BMS-688521 (Standard)
0 ImagesCat. No.: HY-10596RCAS No.: 893397-44-9BMS-688521 (Standard) is the analytical standard of BMS-688521 (HY-10596). This product is intended for research and analytical applications. BMS-688521 is a highly potent, orally active inhibitor of the LFA-1/ICAM interaction, with an IC50 of 2.5 nM in the adhesion assay and an IC50 of 60 nM in the MLR assay. BMS-688521 is efficacious in a mouse allergic eosinophilic lung inflammation model.
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Fradafiban
0 ImagesCat. No.: HY-101720CAS No.: 148396-36-5Synonyms: BIBU-52Fradafiban is a nonpeptide platelet glycoprotein IIb/IIIa antagonist, which binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM.
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SC-52012
0 ImagesCat. No.: HY-19163CAS No.: 145643-15-8HY-19163 is an orally active fibrinogen receptor antagonist, with antiplatelet activities.
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Sibrafiban (Standard)
0 ImagesCat. No.: HY-10309RCAS No.: 172927-65-0Synonyms: RO 48-3657 (Standard)Sibrafiban (Standard) is the analytical standard of Sibrafiban. This product is intended for research and analytical applications. Sibrafiban (RO 48-3657) is the orally active, nonpeptide, double-proagent of Ro 44-3888 and a selective glycoprotein IIb/IIIa receptor antagonist. Sibrafiban inhibits platelet aggregation.
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EMD527040 (Standard)
0 ImagesCat. No.: HY-101473RCAS No.: 851333-14-7
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BIO7662
0 ImagesCat. No.: HY-123802CAS No.: 327613-10-5
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L123Z358
0 ImagesCat. No.: HY-185470CAS No.: 3110942-12-3L123Z358 is a ligand of αvβ6 integrin. L123Z358 can be conjugated with siRNA to achieve targeted drug delivery to muscle tissue.
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Certepetide-13C2,15N
0 ImagesCat. No.: HY-P3448S1Synonyms: CEND-1-13C2,15N; iRGD-13C2,15N; LSTA1-13C2,15NCertepetide-13C2,15N (CEND-1-13C2,15N) is the 13C- and 15N-labeled Certepetide (HY-P3448). Certepetide (CEND-1) is a bifunctional cyclic peptide (a.k.a. iRGD). Certepetide is a tumor-penetrating enhancer via RGD motif interaction with alphav-integrins and via activating NRP-1, and transforms the solid tumor microenvironment into a temporary agent conduit. Certepetide accumulates in tumors, and is used in the research of pancreatic cancer and other solid tumors.
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Orbofiban acetate (Standard)
0 ImagesCat. No.: HY-10304ARCAS No.: 163250-91-7Orbofiban acetate (Standard) is the analytical standard of Orbofiban acetate (HY-10304A). This product is intended for research and analytical applications. Orbofiban acetate is an orally active platelet GPIIb/IIIa antagonist that inhibits platelet aggregation.
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Cyclo(RGDyK) trifluoroacetate (Standard)
0 ImagesCyclo(RGDyK) (trifluoroacetate) (Standard) is the analytical standard of Cyclo(RGDyK) (trifluoroacetate) (HY-100563). This product is intended for research and analytical applications. Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
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Leukadherin-1 (Standard)
0 ImagesCat. No.: HY-15701RCAS No.: 344897-95-6Leukadherin-1 (Standard) is the analytical standard of Leukadherin-1. This product is intended for research and analytical applications. Leukadherin-1, a specific agonist of the leukocyte surface integrin CD11b/CD18, increases CD11b/CD18-dependent cell adhesion to fibrinogen with an EC50 of 4 μM. Leukadherin-1 enhances leukocyte adhesion to ligands (such as ICAM-1) and vascular endothelium and thus reduces leukocyte transendothelial migration and influx to the injury sites. Leukadherin-1 suppresses innate inflammatory signaling.
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DL-Propargylglycine hydrochloride
0 ImagesCat. No.: HY-W051612CAS No.: 16900-57-5DL-Propargylglycine hydrochloride is an irreversible and selective CSE inhibitor that blocks the biosynthesis of endogenous hydrogen sulfide. DL-Propargylglycine hydrochloride induces ROS and TGF-β1 expression. DL-Propargylglycine hydrochloride downregulates carotid ACE2 and Ang-(1-7), and elevates Ang II. DL-Propargylglycine hydrochloride upregulates ICAM-1/LFA-1, exacerbating Aspirin (HY-14654)-induced gastric mucosal injury. DL-Propargylglycine hydrochloride is used in research on diabetes-induced liver injury, diabetic nephropathy, atherosclerosis, gastric mucosal injury, hemorrhagic shock, and Streptococcus agalactiae infection.
