Kinesin Inhibitor

Terpendole E is a mitotic kinesin Eg5 inhibitor. Terpendole E inhibits both motor and microtubule-stimulated ATPase activities of human Eg5. Terpendole E induces formation of a monoastral spindle in M phase.

Cenpemlin is a CENP-M inhibitor that disrupts the CENP-M/CENP-L interaction. Cenpemlin can be used for investigating centromere-kinetochore interactions and dynamic kinetochore assembly during cell division.

Ispinesib (SB-715992) mesylate is a specific inhibitor of kinesin spindle protein (KSP), with a K_{i app} of 1.7 nM.

ALN-12115 is a siRNA that targets kinesin spindle protein (KSP), and it is one of the siRNAs in ALN-VSP.ALN-VSP is a lipid nanoparticle formulation containing two siRNAs for KSP and VEGF with potential antitumor activity.

MKLP2-IN-1 (compound 12a) is an inhibitor of MKLP2 with good oral bioavailability. MKLP2-IN-1 inhibits the microtubule-stimulated ATPase activity of recombinant MKLP2 in vitro and suppresses tumor growth in a mouse Calu-6 lung cancer model.

Kif6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kif6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

KIF18A-IN-15 (Compound Example 36) is a KIF18A inhibitor, available in two forms, EX36-A and its enantiomer EX36-B, with IC₅₀s of 0.01-0.1 μM, respectively. EX36-A and EX36-B inhibit OVCAR-3 cells viability with IC₅₀s of 0.01-0.1 μM and 0-0.01 μM, respectively. KIF18A-IN-15 can be used in tumor (e.g. colon, breast, lung) studies.

O-Trityl-L-serine is an inhibitor of human mitotic kinesin Eg5, with a K_i^app of 750 nM. O-Trityl-L-serine does not induce monopolar spindle formation or mitotic arrest in cancer cells. O-Trityl-L-serine can be used in cancer-related research.

KIF18A-IN-18 (Compound I) is a KIF18A inhibitor. KIF18A-IN-18 can be used in the research of chromosomally unstable tumors.

CCT369834 is an ATP-competitive HSET inhibitor with an IC₅₀ of 39 nM. CCT369834 is a trans-cyclooctene-tagged probe. CCT369834 and HSET specifically co-localize on mitotic spindles. CCT369834 can be used for the research of cancer.

Eg5-IN-3 (5) is an Eg5 inhibitor that targets the novel allosteric pocket (α4/α6/L11). Eg5-IN-3 (5) causes tubulin assembly distortion with irregular morphology, resulting in a typical mitotic arrest similar to Monastrol (HY-101071A).

KIF14 Human Pre-designed siRNA Set A contains three designed siRNAs for KIF14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

KIF18A-IN-16 (Compound 15) is a fused ring KIF18A inhibitor. KIF18A-IN-16 can be used in oncology (e.g., colon, breast, lung cancer) studies.

CK0106023 is a potent and specific allosteric inhibitor of KSP with a K_i value of 12 nM, showing antitumor activity. CK0106023 causes mitotic arrest and growth inhibition in several tumor cell lines. CK0106023 exhibits antitumor activity in tumor-bearing mice.

KIF18A-IN-17 (Example 37A) is a KIF18A inhibitor with racemic form with an IC₅₀ of 48 nM. KIF18A-IN-17 exhibits anti-proliferative activity against HT29 cells. KIF18A-IN-17 can be used for the study of cancers such as breast cancer and ovarian cancer.

CENP-E-IN-3 (compound 4) is a potent CENP-E inhibitor. CENP-E-IN-3 has the potential for the research of cancer.

4'-Methoxy-S-trityl-L-cysteinol is an allosteric inhibitor of vertebrate Kinesin Spindle Protein (KSP). 4'-Methoxy-S-trityl-L-cysteinol significantly enhances its inhibitory activity against NCI60 tumor cells by modifying the trityl and cysteine groups. Its EC50 for bipolar spindle formation is 28 μM, showing stronger inhibitory potency than the parent molecule and monastrol.

Monastrol (Standard) is the analytical standard of Monastrol (HY-101071A). This product is intended for research and analytical applications. Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5 with an IC50 value of 14 μM.

BTB-1 (Standard) is the analytical standard of BTB-1 (HY-101770). This product is intended for research and analytical applications. BTB-1 is a potent, selective and reversible mitotic motor protein Kif18A inhibitor with an IC₅₀ of 1.69 μM.

Monastroline (HR22C16) is an effective and selective inhibitor of the mitotic kinesin Eg5, exhibiting strong cell permeability.