Monoamine Oxidase
MAO
Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. They belong to the protein family of flavin-containing amine oxidoreductases. Monoamine oxidases catalyze the oxidative deamination of monoamines. Oxygen is used to remove an amine group from a molecule, resulting in the corresponding aldehyde and ammonia. Monoamine oxidases contain the covalently bound cofactor FAD and are, thus, classified as flavoproteins. Because of the vital role that MAOs play in the inactivation of neurotransmitters, MAO dysfunction is thought to be responsible for a number of psychiatric and neurological disorders. MAO-A inhibitors act as antidepressant and antianxiety agents, whereas MAO-B inhibitors are used alone or in combination to treat Alzheimer’sand Parkinson’s diseases.
Monoamine Oxidase Isoform Specific Products
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Monoamine Oxidase Inhibitors
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Monoamine Oxidase Activators
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Monoamine Oxidase Modulators
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Monoamine Oxidase Chemicals
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Monoamine Oxidase Substrate
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Monoamine Oxidase Ligands
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Monoamine Oxidase Related Products (511)
Related Products (511)
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Antibodies (2)
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Monoamine Oxidase Isoform Comparison
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Desoxypeganine
0 ImagesDesoxypeganine (Deoxypeganine), an alkaloid, is a potent and orally active cholinesterase (BChE and AChE) and selective MAO-A inhibitor, with IC50 values of 2, 17, and 2 μM, respectively. Desoxypeganine can be used for alcohol abuse research.
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Multitarget AD-IN-5
0 ImagesCat. No.: HY-181041Multitarget AD-IN-5 (Compound 20), 9-Aminoacridine (HY-B1422) derivative, is a neuroprotective agent. Multitarget AD-IN-5 shows IC50 values of 0.614, 0.448, 3.73 and 1.55 μM for hAChE, hBChE, hMAO-A and hMAO-B. Multitarget AD-IN-5 can reduce length and diameter of Aβ42 fibers, and decrease the number of fibers per unit area. Multitarget AD-IN-5 can be used for research of Alzheimer's disease.
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MAO-A-IN-5
0 ImagesCat. No.: HY-186306CAS No.: 1898180-94-3MAO-A-IN-5 (compound 4g) is a selective human monoamine oxidase A (MAO-A) inhibitor with an IC50 of 0.250 μM against MAO-A. MAO-A-IN-5 competitively inhibits the activity of MAO enzymes, impedes the metabolism of neurotransmitter amines, and potentially reduces hydrogen peroxide produced by the MAO-catalyzed cycle. MAO-A-IN-5 can be used for research on Parkinson's disease and depression.
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HDAC1/MAO-B-IN-1
0 ImagesCat. No.: HY-145845CAS No.: 2759855-37-1
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PSH18
0 ImagesCat. No.: HY-184893PSH18 is a selective monoamine oxidase B (MAO-B) inhibitor with blood-brain barrier permeability, with a human-derived IC50 of 0.95 μM and a Ki of 0.89 μM. PSH18 can be used for the research of Parkinson's disease.
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MAO-B-IN-3
0 ImagesCat. No.: HY-143329CAS No.: 3037516-21-2MAO-B-IN-3 is a reversible and selective MAO-B inhibitor (IC50=96 nM). MAO-B-IN-3 also binds to 5-HT6R with Ki value of 696 nM. MAO-B-IN-3 can be used for research of in Alzheimer's disease.
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5-LOX-IN-7
0 ImagesCat. No.: HY-117514CAS No.: 1272519-89-75-LOX-IN-7 (compound 18) is a potent LOX inhibitor. 5-LOX-IN-7 has the potential for the research of inflammatory and allergic diseases and certain cancer.
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MAO-B-IN-5
0 ImagesCat. No.: HY-115986CAS No.: 849909-77-9MAO-B-IN-5 is a potent, selective and orally active MAO-B inhibitor with an IC50 of 0.204 µM. MAO-B-IN-5 has the potential for the research of Parkinson's disease (PD).
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MAO-A/B-IN-5
0 ImagesCat. No.: HY-178149MAO-A/B-IN-5 is an orally active MAO-A (IC50 = 73.88 μM) and MAO-B (IC50 = 91.08 μM) inhibitor. MAO-A/B-IN-5 reverses Sodium nitroprusside (SNP) (HY-B0564)-induced cerebral lipid peroxidation (IC50 = 130.2 μM) and protein carbonylation (IC50 = 229.8 μM). MAO-A/B-IN-5 shows dose-dependent and time-dependent antidepressant-like efficacy in mice. MAO-A/B-IN-5 can be used for the study of depressive disorder.
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MAO-IN-5
0 ImagesCat. No.: HY-163415CAS No.: 906728-07-2MAO-IN-5 (Compound ZINC000016952895) is a monoamine oxidase (MAO) inhibitor. According to the prediction of Swiss ADME, MAO-IN-5 can inhibit the CYP enzyme family, has blood-brain barrier (BBB) permeability, and has a high gastrointestinal absorption rate. MAO-IN-5 can be used in the study of neurological diseases.
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AChE/MAO-B-IN-6
0 ImagesCat. No.: HY-157090AChE/MAO-B-IN-6 (compound 3a) is a dual inhibitor of AChE and h-MAO-B with potential to inhibit Alzheimer's disease.
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Sembragiline
0 ImagesCat. No.: HY-16731CAS No.: 676479-06-4Synonyms: EVT 302; RG1577; RO4602522Sembragiline (EVT 302) is a potent, selective and reversible monoamine oxidase B (MAO-B) inhibitor. Sembragiline reduces the metabolism of dopamine and other amine neurotransmitters by inhibiting the activity of the MAO-B enzyme, thereby potentially increasing the concentration of these neurotransmitters in the brain. Inhibition of the MAO-B enzyme also reduces the formation of toxic reactive oxygen species (ROS) that play a role in the pathological process of AD. Sembragiline has good oral activity and blood-brain barrier permeability. Sembragiline can be used in studies of AD, especially in patients with AD who show increased MAO-B activity.
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LSD1-IN-26
0 ImagesCat. No.: HY-149978CAS No.: 3041141-72-1LSD1-IN-26 (compound 12u) is a potent LSD1 inhibitor, with an IC50 of 25.3 nM. LSD1-IN-26 also inhibits MAO-A (IC50=1234.57 nM) and MAO-B (IC50=3819.27 nM). LSD1-IN-26 significantly induces apoptosis in MGC-803 cells. LSD1-IN-26 can be used for gastric cancer research.
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MAO-B-IN-51
0 ImagesCat. No.: HY-103477CAS No.: 947540-06-9MAO-B-IN-51 (Compound 8f) is a selective, blood-brain-barrier permeable, orally active MAO-B inhibitor with an IC50 of 48．9 nM (MDS). MAO-B-IN-51 enhances long-term memory.
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Dual AChE-MAO B-IN-3
0 ImagesCat. No.: HY-151885Dual AChE-MAO B-IN-3 (compound C10) is a potent dual AChE/MAO-B inhibitior, with IC50 values of 0.58 and 0.41 μM, respectively. Dual AChE-MAO B-IN-3 is a dual-binding inhibitor bound to both the catalytic anionic site and peripheral anionic site of AChE. Dual AChE-MAO B-IN-3 can be used for Alzheimer’s disease (AD) research.
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2-PAT
0 ImagesCat. No.: HY-143438CAS No.: 134467-58-6
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C175-0062
0 ImagesCat. No.: HY-162303CAS No.: 686736-69-6C175-0062 is a monoamine oxidase B (MAO-B) inhibitor. C175-0062 can be used for the research of neurodegenerative disorders, including Parkinson's disease (PD), Alzheimer’s disease (AD), and amyotrophic lateral sclerosis (ALS).
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Harmane (Standard)
0 ImagesHarmane (Standard) is the analytical standard of Harmane. This product is intended for research and analytical applications. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively). Harmane exhibits comutagenic effect.
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Bazinaprine
0 ImagesCat. No.: HY-106741CAS No.: 94011-82-2Synonyms: SR 95191Bazinaprine (SR 95191), a derivative of Minaprine (HY-B0884), is an orally active inhibitor of type A monoamine oxidase (MAO). Bazinaprine can be used for research of depression.
