Parasite
Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases such as nematodes, cestodes, trematodes, and infectious protozoa.
Parasite Isoform Specific Products
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Parasite Related Products (2534)
Related Products (2534)
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Related Compound Screening Libraries (1)
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Parasite Isoform Comparison
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Salviandulin E
0 ImagesCat. No.: HY-N11550CAS No.: 158994-32-2Salviandulin E is a diterpenoid compound that can be isolated from Salvia leucantha CAV.. Salviandulin E shows antitrypanosomal activity against T. b. brucei GUTat 3.1 parasites with an IC50 value of 0.72 µg/mL.
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Antimalarial agent 23
0 ImagesCat. No.: HY-149919Antimalarial agent 23 is an antimalarial benzimidazole with IC50s of 0.08 μM and 0.10 μM for PfNF54 and PfK1, respectively. Antimalarial agent 23 has potent β-hematin inhibition activity. Antimalarial agent 23 does not directly inhibit the conversion of heme to hemozoin.
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Anti-infective agent 5
0 ImagesCat. No.: HY-151485CAS No.: 2738381-47-8Anti-infective agent 5 (compound 74) is an orally active inhibitor of Trypanosoma cruzi with an IC50 value of 0.10 μM. Anti-infective agent 5 effectively reduces parasite burden in vivo. Anti-infective agent 5 can be used for the research of infection.
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Antileishmanial agent-41
0 ImagesCat. No.: HY-183290Antileishmanial agent-41 (Compound 20k) is a selective Antileishmanial agent with a IC50 of 1.51 μg/mL against Leishmania donovani. Antileishmanial agent-41 increases ROS levels. Antileishmanial agent-41 can be used for the research of leishmaniasis.
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Cletoquine-d4
0 ImagesSynonyms: Desethylhydroxychloroquine-d4Cletoquine-d4 is deuterium labeled Cletoquine. Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment.
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Sitamaquine tosylate
0 ImagesCat. No.: HY-19688BCAS No.: 1019640-33-5Synonyms: WR 6026 tosylateSitamaquine (WR6026) tosylate, an orally active 8-aminoquinoline analog, is an antileishmanial agent. Sitamaquine tosylate inhibits mitochondrial complex II (succinate dehydrogenase). Sitamaquine tosylate is a lipophilic weak base that rapidly accumulates in acidic compartments of Leishmania spp., mainly in acidocalcisomes.
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P-536
0 ImagesCat. No.: HY-105111CAS No.: 93426-60-9P-536 is a ACE inhibitor that also inhibits herpes simplex virus HSV-1 thymidine kinase and Trypanosoma cruzi RNA polymerase. By inhibiting the renin-angiotensin system, downregulating the expression of AT1R and NOX4, and reducing oxidative stress (decreasing plasma hydrogen peroxide (H2O2) and 8-isoprostaglandin levels), P-536 effectively reduces systolic blood pressure and improves vascular reactivity. P-536 also inhibits the replication of DNA/RNA viruses such as HSV-1 by blocking nucleotide metabolism and nucleic acid synthesis, competitively inhibits RNA synthesis in Trypanosoma cruzi, and inhibits amastigote replication, thereby impeding its growth. P-536 is suitable for research on hypertension, insulin resistance, and Chagas disease.
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CpNMT-IN-1
0 ImagesCat. No.: HY-172098CpNMT-IN-1 (Compound 11e) is an against N-myristoyltransferase of C. parvum (CpNMT) inhibitor with an IC50 value of 2.5 μM. CpNMT-IN-1 also inhibits the growth of C. parvum with an EC50 value of 6.9 μM.
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19,20-Epoxycytochalasin C
0 ImagesCat. No.: HY-N8385CAS No.: 189351-79-919,20-Epoxycytochalasin C, a cytochalasin, is a fungal metabolite from Nemania sp. 19,20-Epoxycytochalasin C shows potent in vitro antiplasmodial activity and phytotoxicity.
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Antileishmanial agent-42
0 ImagesCat. No.: HY-183362Antileishmanial agent-42 is an antileishmanial agent. Antileishmanial agent-42 has favorable interactions with key active site residues (e.g., Ser63, Asn66/295/299) of adenosine kinase. Antileishmanial agent-42 exerts activity against promastigote and amastigote forms of L. amazonensis, L. braziliensis, L. infantum, and L. donovani.
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Pafuramidine (Standard)
0 ImagesSynonyms: DB289 (Standard)Pafuramidine (Standard) is the analytical standard of Pafuramidine. This product is intended for research and analytical applications. Pafuramidine (DB289) is an orally active proagent of Furamidine (HY-110137A). Pafuramidine is a potent anti-parasitic agent, can be used to research trypanosomiasis, Pneumocystis pneumonia and malaria.
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Allosamidin
0 ImagesCat. No.: HY-120827CAS No.: 103782-08-7Synonyms: A82516Allosamidin (A82516) is an insect chitinase inhibitor with an IC50 of 0.35 μM against Bombyx mori chitinase.
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5,7,8-Trimethoxycoumarin
0 ImagesCat. No.: HY-N2656CAS No.: 60796-65-85,7,8-Trimethoxycoumarin is an anti-parasite agent with IC50s of 25.5 μM and 57.7 μM against Trypanosoma cruzi and L. amazonensis, respectively.
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Antimalarial agent 28
0 ImagesCat. No.: HY-155536CAS No.: 3038772-78-7Antimalarial agent 28 (Compound 2i) is an antiplasmodial agent. Antimalarial agent 28 inhibits P. berghei, with IC50s of 0.561 μM, 0.14 μM, 4.34 μM for Liver stage, early gametocytes and ring stages of P. falciparum.
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DNDI-8219
0 ImagesCat. No.: HY-124623CAS No.: 2222660-40-2DNDI-8219 (compound 58) is a potent selective and orally active trypanocidal agent, possessing inhibitory activity against Trypanosoma cruzi (T. cruzi) with an IC50 of 0.4 μM. DNDI-8219 has low cytotoxicity (L6 cells IC50 > 100 μM). DNDI-8219 can effectively cure chronic T. cruzi infection and markedly reduce parasite burdens in mouse model. DNDI-8219 has good solubility, metabolic stability and safety.
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Dianellin
0 ImagesCat. No.: HY-N19628CAS No.: 58829-72-4Dianellin is an orally active anti-malarial agent found in Kniphofia foliosa. Dianellin binds to Plasmodium falciparum plasmepsin II and shows anti-malarial activity in mice. Dianellin can be used for the research of malaria.
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Amitraz-d6
0 ImagesCat. No.: HY-B1111SCAS No.: 2734300-36-6Synonyms: BTS-27419-d6Amitraz-d6 (BTS-27419-d6) is the deuterium labeled Amitraz. Amitraz is a non-systemic acaricide and insecticide, with alpha-adrenergic agonist activity, interaction with octopamine receptors of the central nervous system and inhibition of monoamine oxidases and prostaglandin synthesis.
