Ser/Thr Protease
Serine proteases; Serine endopeptidases; Threonine proteases
Serine (Ser) proteases catalyse the hydrolysis of specific peptide bonds in their substrates and this activity depends on a set of amino acids in the active site of the enzyme, one of which is always a serine. There are two families especially well studied, the trypsin family and the subtilisin family. Serine proteases play crucial roles in a wide variety of cellular as well as extracellular functions, including the process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing. Threonine (Thr) proteases are a family of proteolytic enzymes harbouring a threonine residue within the active site. The prototype members of this class of enzymes are the catalytic subunits of the proteasome, however the acyltransferases convergently evolved the same active site geometry and mechanism.
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Ser/Thr Protease Inhibitors
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Ser/Thr Protease Modulator
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Ser/Thr Protease Degrader
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Ser/Thr Protease Control
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Ser/Thr Protease Substrates
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Ser/Thr Protease Ligand
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Ser/Thr Protease Related Products (379)
Related Products (379)
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Antibodies (11)
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Ac-Gly-Lys-OMe acetate
0 ImagesAc-Gly-Lys-OMe acetate is a substrate for urokinase. Ac-Gly-Lys-OMe acetate can be used to measure the effects of small molecule inhibitors on urokinase activity.
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7-Oxogedunin
0 ImagesCat. No.: HY-178898CAS No.: 13072-74-77-Oxogedunin (Compound 7DG; Compound 16) is a small molecule that protects macrophages from cell pyroptosis induced by anthrax lethal toxin (LT). Its target is protein kinase R (PKR). 7-Oxogedunin can widely inhibit the assembly of various inflammasomes (NLRP1 and NLRP3) and the activation of caspase-1 by inhibiting the kinase-independent function of PKR. 7-Oxogedunin has growth inhibitory activity on European corn borer larvae. 7-Oxogedunin can be used for LT toxicity inhibition and pest control research.
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D-Val-Gly-Arg-pNA
0 ImagesCat. No.: HY-P10005CAS No.: 80798-23-8D-Val-Gly-Arg-pNA is a chromogenic substrate of TPA (tissue plasminogen activator). D-Val-Gly-Arg-pNA can be used to detect the amidolytic activity of TPA I and TPA II.
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RPP-(Gly-13C2,15N)-FSPFR TFA
0 ImagesCat. No.: HY-P0206S1RPP-(Gly-113C2,15N)-FSPFR TFA is 13C- and 15N-labeled Bradykinin (HY-P0206). Bradykinin is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain.
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CatB-IN-1
0 ImagesCat. No.: HY-116264CAS No.: 1417737-67-7CatB-IN-1 is an enzyme inhibitor with significant inhibitory activity against tumor invasion. CatB-IN-1 may reduce the invasiveness of tumor cells by regulating intracellular protein metabolism. CatB-IN-1 demonstrates effective anti-invasive ability in cell models and can significantly reduce the invasive ability of MCF-10A neoT cells. The structure-activity relationship study of CatB-IN-1 shows that its design can target multiple functions of cat hepsin B.
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Suc-AAPY-pNA
0 ImagesCat. No.: HY-P11734CAS No.: 72682-75-8Suc-AAPY-pNA is an oligptide compound and protease substrate. Suc-AAPY-pNA undergoes hydrolysis by proteases at the peptide bond between tyrosine and p-nitroaniline, releasing p-nitroaniline with an absorption peak at OD410. Suc-AAPY-pNA functions as a substrate in preclinical assays for measuring activity of acidic, neutral, and alkaline proteases.
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Antipain
0 ImagesCat. No.: HY-127039CAS No.: 37691-11-5Antipain is a protease inhibitor isolated from Actinomycetes. Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain restricts uterine DNA synthesis and function in mice.
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Trypsin, Rat
0 ImagesCat. No.: HY-129047HTrypsin, Rat (EC 3.4.21.4) is a serine protease belonging to the PA superfamily. It is present in the digestive systems of many vertebrates and hydrolyzes proteins. Trypsin, Rat (EC 3.4.21.4) primarily cleaves peptide chains at the carboxyl terminus of lysine or arginine, but cleavage does not occur when lysine or arginine is followed by proline.
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JTV-803
0 ImagesCat. No.: HY-187960CAS No.: 247131-06-2JTV-803 is a selective and competitive direct factor Xa (FXa) inhibitor with a Ki of 19 nM and an IC50 of 81 nM against human FXa, and its action is independent of antithrombin III (ATIII). JTV-803 exhibits significantly higher selectivity for human FXa than for thrombin, plasmin, and trypsin. JTV-803 produces sustained ex vivo anti-FXa inhibitory activity in vivo. JTV-803 prolongs aPTT and PT, prevents dialyzer thrombosis, and is cleared during dialysis. JTV-803 dose-dependently attenuates coagulation activation, maintains plasma ATIII activity, reduces glomerular fibrin deposition, and improves survival rate. JTV-803 can be used for research related to thrombosis and hemodialysis anticoagulation.
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MD5
0 ImagesCat. No.: HY-P11260CAS No.: 3051556-89-6MD5 is a selective TMPRSS6 mimetic peptide inhibitor with an IC50 for recombinant human TMPRSS6 protein of 22 nM and a Ki of 3.4 nM. MD5 exhibits the significantly reduced inhibitory effect on Matriptase, with an IC50 of 352 nM and a Ki of 99.2 nM. MD5 exhibits good target specificity and only has a weak inhibitory effect on thrombin (Thrombin), with Ki of 120 nM. MD5 demonstrates good initial drugability and can be used for the study of iron overload diseases (such as hereditary hemochromatosis, β-thalassemia).
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H-Leu-Ser-Phe(NO2)-Nle-Ala-OMe TFA
0 ImagesCat. No.: HY-P3725CAS No.: 99764-63-3H-Leu-Ser-Phe(NO2)-Nle-Ala-OMe TFA is a substrate for chymosin.
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Cathepsin Inhibitor 3
0 ImagesCat. No.: HY-149926CAS No.: 3026372-49-3Cathepsin Inhibitor 3 (Compound 53k) is a non-radioactive intermediate in compound [18F] 2k radioactive synthesis, which has selectivity for cathepsin S. Cathepsin Inhibitor 3 can undergo radioactive fluorination and can be used for fluorine-18 labeling research. Cathepsin Inhibitor 3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Boc-Gln-Ala-Arg-AMC hydrochloride
0 ImagesCat. No.: HY-134432ACAS No.: 201849-55-0Boc-Gln-Ala-Arg-AMC hydrochloride is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC hydrochloride can also be used for measuring the proteolytic activity of TMPRSS2.
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(Arg) 9
0 ImagesCat. No.: HY-P0133CAS No.: 143413-47-2Synonyms: Nona-L-arginine; Peptide R9(Arg)9 (Nona-L-arginine) is a cell-penetrating peptide (CPP) made up of 9 arginine residues, which is an inhibitor of serine endoprotease Furin. (Arg)9 has neuroprotective property, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model.
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AMG-126737
0 ImagesCat. No.: HY-126980CAS No.: 224054-76-6AMG-126737 is an orally active and highly selective human mast cell tryptase inhibitor with a Ki of 90 nM. AMG-126737 suppresses early/late-phase bronchoconstriction in sheep models. AMG-126737 is promising for research of asthma and allergic diseases.
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Manusiran sodium scrambled negative control
0 ImagesCat. No.: HY-147278CManusiran sodium scrambled negative control is the sequence scrambled negative control of Manusiran sodium.
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MI-1904
0 ImagesCat. No.: HY-161902CAS No.: 3033379-90-4MI-1904 is the inhibitor for matriptase/TMPRSS2, that exhibits antiviral activity against influenza virus H1N1 and H9N2. MI-1904 blocks the cleavage of glycoproteins on the viral surface, prevents the virus from binding to host cell receptors, and thus inhibits the entry and replication of the virus.
