2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. VD/VDR

VD/VDR

Vitamin D; Vitamin D receptor

VD/VDR

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Vitamin D is a secosteroidalprohormone, it can be synthesized at sufficient levels in skin, given adequate skin exposure to UV B radiation from sunlight. Vitamin D modulates its biological effects by directly regulating target gene expression through the Vitamin D receptor (VDR), a ligand-regulated transcription factor and a member of the nuclear receptor superfamily. Whether synthesized in the skin or ingested, vitamin D requires two hydroxylation steps to become the biologically active hormone, 1,25-dyhydroxyvitamin D3 [1,25(OH)2D3], a form that signals through the VDR. The hormone-bound VDR modulates target gene transcription in response to vitamin D. VDR acts as a master transcriptional regulator of autophagy. Activation of the VDR by vitamin D induces autophagy and an autophagic transcriptional signature in breast cancer (BC) cells.

There are 2 forms of vitamin D. Vitamin D2 (ergocalciferol) comes from irradiation of the yeast and plant sterol ergosterol, and vitamin D3 (cholecalciferol) is found in oily fish and cod liver oil and is made in the skin. Vitamin D represents vitamin D2 and vitamin D3.

Topical agents containing active vitamin D3 (calcitriol, 1α, 25- dihydroxyvitaminD3, VD3) analogues such as Tacalcitol, Calcipotriol and Maxacalcitol are widely used for psoriasis therapy.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-32351AS1
    Calcifediol-13C5 monohydrate
    Calcifediol-13C5 monohydrate is the 13C-labeled Calcifediol monohydrate. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels.
    Calcifediol-<sup>13</sup>C<sub>5</sub> monohydrate
  • HY-170975
    UG-650
    		Ligand
    UG-650 is a non-Gemini analog of UVB1 that combines the structural features of UVB1 and MC 1288. UG-650 can bind to the vitamin D receptor (VDR) and inhibit the proliferation of MCF-7 cells and the migration of MC3T3-E1 cells.
    UG-650
  • HY-156868
    22-Hydroxyvitamin D3
    22-Hydroxyvitamin D3 a novel vitamin D analog, that displays no vitamin D agonist activity in the intestine or in bone.
    22-Hydroxyvitamin D3
  • HY-113958S
    Difethialone-d4
    Difethialone-d4 (Baraki-d4; LM 2219-d4) is the deuterium labeled Difethialone (HY-113958). Difethialone (LM-2219) is an anticoagulant rodenticide. Difethialone shows high rodenticide activity in warfarin-sensitive and resistant strains of rats and mice. Difethialone interferes with the circulation of vitamin K in the liver, preventing the synthesis of coagulation factors, resulting in the inability of the blood to coagulate properly, ultimately causing internal bleeding and death. Difethialone can be used in studies of ecological impacts.
    Difethialone-d<sub>4</sub>
  • HY-106561
    Tioclomarol
    		Antagonist
    Tioclomarol, a coumarin anticoagulant, is a vitamin K antagonist.
    Tioclomarol
  • HY-32349S2
    Ercalcidiol-d9
    Ercalcidiol-d9 (25-Hydroxy Vitamin D2-d9) is the deuterium labeled Ercalcidiol (HY-32349). Ercalcidiol is a metabolite of vitamin D2, is regarded as an indicator of vitamin D nutritional status.
    Ercalcidiol-d<sub>9</sub>
  • HY-142129
    Pyrocholecalciferol
    Pyrocholecalciferol, a vitamin D analogue, produced by photochemical transformation of 7-dehydrocholesterol (7-DHC).
    Pyrocholecalciferol
  • HY-32351S3
    Calcifediol-d9
    Calcifediol-d9 (25-hydroxy Vitamin D3-d9) is the deuterium labeled Calcifediol (HY-32351). Calcifediol (25-hydroxy Vitamin D3) is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels.
    Calcifediol-d<sub>9</sub>
  • HY-W745719
    Coumachlor-d4
    Coumachlor-d4 is the deuterium labeled Coumachlor (HY-W013200). Coumachlor is an orally active antieoagulant agent. Coumachlor is a vitamin K antagonist.
    Coumachlor-d<sub>4</sub>
  • HY-A0145R
    Phenprocoumon (Standard)
    		Antagonist
    Phenprocoumon (Standard) is the analytical standard of Phenprocoumon. This product is intended for research and analytical applications. Phenprocoumon is a coumarin derivative that acts as a long acting oral anticoagulant and an antagonist of vitamin K.
    Phenprocoumon (Standard)
  • HY-113958
    Difethialone
    		Inhibitor 99.84%
    Difethialone (LM-2219) is an anticoagulant rodenticide. Difethialone shows high rodenticide activity in warfarin-sensitive and resistant strains of rats and mice. Difethialone interferes with the circulation of vitamin K in the liver, preventing the synthesis of coagulation factors, resulting in the inability of the blood to coagulate properly, ultimately causing internal bleeding and death. Difethialone can be used in studies of ecological impacts.
    Difethialone
  • HY-117182
    LG190178
    LG190178 is a non-steroidal vitamin D receptor (VDR) ligand that can induce the formation of heterodimer complexes between VDR and retinoid X receptor (RXR), stabilizing the agonistic conformation of the VDR ligand-binding domain and promoting its interaction with co-activators. LG190178 has functions in regulating calcium homeostasis, bone mineralization, as well as cell proliferation, differentiation, and apoptosis, making it useful for research in psoriasis, osteoporosis, and cancer.
    LG190178
  • HY-178336
    AC-340
    		Agonist
    AC-340 is a potent hybrid VDR agonist/HDAC inhibitor. AC-340 superinduces VDR target genes (e.g., CYP24A1) and inhibits HDAC6 (IC50 = 0.37 μM) with ~10-fold selectivity over HDAC2. AC-340 induces VDR hyperagonism by causing widespread protein hyperacetylation (e.g., tubulin and H3K9/K27), which leads to elevated H3K27 acetylation on VDR target genes. AC-340 can be used for melanoma cancer research.
    AC-340
  • HY-179431
    VDR ligand-1
    		Agonist
    VDR ligand-1 (compound 13a) is a nonsecosteroidal VDR agonist with an EC50 value of 16 nM. VDR ligand-1 can be used for osteoporosis, psoriasis, and cancer research.
    VDR ligand-1
  • HY-14863
    Lunacalcipol
    		Agonist
    Lunacalcipol (CTA-018), as a vitamin D analogue, has a dual role in the pathogenesis of Chronic Kidney Disease (CKD), as an agonist of vitamin D receptor and an antagonist of cytochrome P450 enzyme 24-hydroxylase. Lunacalcipol binds to VDR and regulates transcriptional activity of VDR by influencing ligand binding affinity, ligand-dependent coactivator recruitment or inhibitory factor dissociation, efficiency of ligand entry into target cells, tissue specificity and different metabolism of ligand. Lunacalcipol can be used in the study of CKD, especially Secondary Hyperparathyroidism (sHPT).
    Lunacalcipol
  • HY-32348R
    Doxercalciferol (Standard)
    		Activator
    Doxercalciferol (Standard) is the analytical standard of Doxercalciferol. This product is intended for research and analytical applications. Doxercalciferol is a Vitamin D2 analog, acts as an activator of Vitamin D receptor, and prevent renal disease.
    Doxercalciferol (Standard)
  • HY-32349S3
    Ercalcidiol-13C3
    Ercalcidiol-13C3 (25-Hydroxy Vitamin D2-13C3) is the 13C-labeled Ercalcidiol (HY-32349). Ercalcidiol is a metabolite of vitamin D2, is regarded as an indicator of vitamin D nutritional status.
    Ercalcidiol-<sup>13</sup>C<sub>3</sub>
  • HY-166525S
    24R-Calcipotriol-d4
    		Activator
    24R-Calcipotriol-d4 (PRI 2202-d4; Impurity D of Calcipotriol-d4) is the deuterium labeled 24R-Calcipotriol. 24R-Calcipotriol is an impurity of Calcipotriol. Calcipotriol is a ligand of VDR-like receptors.
    24R-Calcipotriol-d<sub>4</sub>
  • HY-A0145S
    Phenprocoumon-d5
    Phenprocoumon-d5 is the deuterium labeled Phenprocoumon (HY-A0145). Phenprocoumon is a coumarin derivative that acts as a long acting oral anticoagulant and an antagonist of vitamin K.
    Phenprocoumon-d<sub>5</sub>
  • HY-76542AR
    5,6-trans-Vitamin D2 (Standard)
    		Control
    5,6-trans-Vitamin D2 (Standard) is the analytical standard of 5,6-trans-Vitamin D2. This product is intended for research and analytical applications. 5,6-trans-Vitamin D2 is the isomer of Vitamin D2[1].
    5,6-trans-Vitamin D2 (Standard)
Cat. No. Product Name / Synonyms Application Reactivity