CD3
Cluster of differentiation 3
CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with the T-cell receptor (TCR) and the CD3-zeta (ζ-chain) to generate an activation signal in T lymphocytes. The TCR, CD3-zeta, and the other CD3 molecules together constitute the TCR complex.
All Product Categories
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CD3 Related Products (110)
Related Products (110)
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Antibodies (20)
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Mipletamig
0 ImagesSynonyms: APVO-436Mipletamig (APVO-436) is a bispecific CD123 x CD3 monoclonal antibody. Mipletamig simultaneously binds to both CD3-expressing T cells and CD123-expressing cancer cells, thereby crosslinking CD123-expressing tumor cells and cytotoxic T lymphocytes (CTLs). This results in the activation and proliferation of T-cells and causes CTL-mediated cell lysis of CD123-expressing tumor cells. Mipletamig can be used for the study of acute myeloid leukemia (AML).
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Podentamig
0 ImagesSynonyms: HPN 217Podentamig (HPN 217) is a trispecific construct with three binding domains, including an anti-CD3 domain for T cell activation, an anti-BCMA domain for binding to plasma cells, and an anti-albumin domain for half-life extension. Podentamig is applicable to research related to relapsed/refractory multiple myeloma.
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Torutamig
0 ImagesCat. No.: HY-P992136CAS No.: 3075939-10-2Torutamig is a monoclonal antibody targeting TNFRSF17/BCMA/CD269&CD3E.
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Ciduvectamig
0 ImagesCat. No.: HY-P990692CAS No.: 2412587-62-1Synonyms: JNJ-70218902; JNJ-902
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Eliroptamig
0 ImagesCat. No.: HY-P992112CAS No.: 3064817-30-4Eliroptamig is a multispecific antibody targeting albumin, folate receptor α (FOLR1) and cluster of differentiation 3 (CD3). Eliroptamig extends its half-life by binding to albumin, while targeting FOLR1 on tumor cells and activating T cells to achieve precise tumor killing.
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Olsutamig
0 ImagesSynonyms: REGN-4336Olsutamig is a bivalent humanized IgG4κ monoclonal antibody inhibitor targeting FOLH1/PSMA and CD3E. Olsutamig simultaneously binds to PSMA on the tumor cell surface and CD3E on the T cell surface, markedly activating T cells and thereby specifically killing prostate cancer cells.
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HPN536
0 ImagesCat. No.: HY-P991088Purity: 99.00%HPN536 is a trispecific, T-cell-activating protein-based construct, which binds to mesothelin-expressing tumor cells, CD3ε on T cells, and to serum albumin. HPN536 specifically redirects T cells for potent redirected lysis of mesothelin-expressing cancer cells with concomitant T-cell activation.
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Varzutamig
0 ImagesCat. No.: HY-P992140CAS No.: 3064817-31-5Varzutamig is a bispecific antibody targeting CD3E/ALB/EGFR.
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Anafiltamig
0 ImagesCat. No.: HY-P991671CAS No.: 3009026-69-8Synonyms: JNJ-80948543Anafiltamig is a trivalent monoclonal antibody inhibitor targeting CD79B, CD3E and MS4A1. Anafiltamig consists of a humanized IgG1κ anti-CD79B arm and a bispecific scFv-based arm targeting CD3E and MS4A1. Anafiltamig simultaneously bridges T and B cells, activating T cells and specifically killing B cell tumors. Anafiltamig can be used for B cell malignancies such as non-Hodgkin lymphoma research.
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Lumivatamig
0 ImagesCat. No.: HY-P991700CAS No.: 3035406-55-1Lumivatamig is an H-γ1_L-κ-scFvhl dimer-type bispecific antibody targeting CLDN18.2 & CD3E.
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PF-07260437
0 ImagesCat. No.: HY-P992524PF-07260437 is a bispecific monoclonal antibody targeting B7-H4 and CD3, with Kd values of 63.5 nM and 66.75 nM against human and cynomolgus monkey CD3, respectively. PF-07260437 simultaneously binds B7-H4 on tumor cells and the CD3ε subunit in the T cell receptor complex, forming a tumor cell-bispecific antibody-T cell trimer. This process establishes an immune synapse and initiates non-MHC-dependent T cell activation, proliferation, and release of cytotoxic molecules such as granzyme B to kill tumor cells. PF-07260437 can be used in research related to advanced or metastatic breast cancer, ovarian cancer, and endometrial cancer.
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AFM15
0 ImagesCat. No.: HY-P991552AFM15 is a humanized monoclonal antibody inhibitor targeting CD3E. AFM15 can be used to study metabolic and immune system diseases, such as type 1 diabetes and inflammatory bowel disease (IBD).
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STI-8811 Antibody
0 ImagesCat. No.: HY-P991877STI-8811 Antibody is an anti-human BCMA antibody. STI-8811 Antibody can generate antibody drug conjugate (ADC) (STI-8811) with an auristatin derivative, Duostatin 5 (HY-145149). STI-8811 Antibody can be used for the study of multiple myeloma.
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Imvotamab
0 ImagesCat. No.: HY-P99660CAS No.: 2573121-53-4Synonyms: IGM-2323Imvotamab (IGM-2323) is a CD20 and CD3 bispecific IGM antibody with dual action mechanism. Imvotamab is used to induce physiological T cell activation to prevent over-stimulation and subsequent down-regulation of immune function. Imvotamab can be used for the study of B-cell malignant tumors, multiple myeloma (MM) and non-Hodgkin's lymphoma (NHL).
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MEDI-2228 Antibody
0 ImagesCat. No.: HY-P991876MEDI-2228 Antibody is an anti-human BCMA antibody that preferentially binds to membrane-bound BCMA versus soluble BCMA. MEDI-2228 Antibody can generate antibody drug conjugate (ADC) (MEDI 2228) with a pyrrolobenzodiazepine (PBD) dimer. MEDI-2228 Antibody can be used for the study of multiple myeloma.
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ST1072
0 ImagesCat. No.: HY-133488CAS No.: 1402703-50-7ST1072 is an inhibitor of CerS4 and CerS6. ST1072 preferentially inhibits CerS6 over CerS4, and reduces the production of C16 ceramide. ST1072 impairs TCR-mediated N-RAS activation, ERK signaling pathway, and the colocalization of CD3/PKCθ. ST1072 decreases the production of IFN-γ as well as the migration of donor cells to target organs. ST1072 regulates immune cell populations and the expression of co-stimulatory molecules. ST1072 can be used in research related to colon cancer, cervical cancer, graft-versus-host disease, and hematologic malignancies.
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MS133
0 ImagesCat. No.: HY-P991463
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TCR-IN-2
0 ImagesCat. No.: HY-180609CAS No.: 2375043-73-3
