Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4062)
Related Products (4062)
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16-Oxo-21-episerratenediol
0 ImagesCat. No.: HY-N17071CAS No.: 24513-50-616-Oxo-21-episerratenediol is a natural triterpene.
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Capsianoside IV
0 ImagesCat. No.: HY-N19726CAS No.: 121924-06-9Capsianoside IV is a monomeric acyclic diterpenoid glycoside and geranyl linalool derivative, which can be isolated from the fruits of Capsicum annuum var. grossum (bell pepper).
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4-Chloronaphthalimide
0 ImagesCat. No.: HY-180426CAS No.: 39061-32-04-Chloronaphthalimide is a derivative of Naphthalimide and can be used as a drug intermediate.
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11-Methoxyuncarine C
0 ImagesCat. No.: HY-N12393CAS No.: 61665-08-5Synonyms: Caboxine B11-Methoxyuncarine C (Caboxine B) is a natural alkaloid.
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WAY-312858
0 ImagesWAY-312858 is an active molecule for the study of amyloid diseases and synucleinopathies.
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4-Methoxy-9,10-dihydrophenanthrene-2,7-di-O-beta-D-glucopyranoside
0 ImagesCat. No.: HY-N21520CAS No.: 1454585-37-54-Methoxy-9,10-dihydrophenanthrene-2,7-di-O-beta-D-glucopyranoside is a glycosidic 9,10-dihydrophenanthrene derivative found in the tubers of Cremastra appendiculata. 4-Methoxy-9,10-dihydrophenanthrene-2,7-di-O-beta-D-glucopyranoside shows in vitro inactivity against human cancer cells.
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MTTA
0 ImagesCat. No.: HY-W709976ACAS No.: 403860-66-2MTTA (mephtetramine) is a psychoactive substance. MTTA can be used as stimulant.
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TGN, Cys modified
0 ImagesCat. No.: HY-P11284BCAS No.: 1418155-47-1TGN, Cys modified is a cysteine modified TGN (HY-P11284) on the C-terminus. TGN, a 12-amino acid ligand, is a BBB-penetrating peptide. TGN can be used as a drug delivery vehicle for Alzheimer's disease research.
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Kahweol oleate
0 ImagesCat. No.: HY-123528CAS No.: 108214-30-8Kahweol oleate is a diterpenoid cafestol that can be isolated from coffee.
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Hydrangeifolin I
0 ImagesCat. No.: HY-N16742CAS No.: 88510-10-5Hydrangeifolin I is a natural phenolic compound.
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Fraxinuacidoside
0 ImagesCat. No.: HY-N17448CAS No.: 942304-06-5Fraxinuacidoside functions as a norditerpene glucopyranoside with a unique carbon skeleton. Fraxinuacidoside can be found in the stem bark of Fraxinus sieboldiana.
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DTPA-adenosylcobalamin
0 ImagesCat. No.: HY-107078CAS No.: 191029-50-2DTPA-adenosylcobalamin is an Adenosylcobalamin (HY-112790) and Pentetic acid (HY-B1335) conjugate. DTPA-adenosylcobalamin can used as a radioactive probe for diagnosing the absorption of vitamin B12 in tumor.
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Albatrelin C
0 ImagesCat. No.: HY-N8937CAS No.: 1417805-17-4Albatrelin C is a natural phenolic compound.
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ORG-25435
0 ImagesCat. No.: HY-19410CAS No.: 256456-73-2ORG-25435 is an alpha amino acid phenolic ester derivative. ORG-25435 has intravenous anesthesia activity. ORG-25435 can be used for anesthesia related research.
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3β-Hydroxy sandaracopimaric acid
0 ImagesCat. No.: HY-N19685CAS No.: 35951-45-23β-Hydroxy sandaracopimaric acid is a diterpene found in the leaves of Juniperus occidentalis with no significant anti-HIV-1 activity.3β-Hydroxy sandaracopimaric acid does not inhibit HIV-1 replication.
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4’-Methoxy-α-ethylaminovalerophenone hydrochloride
0 ImagesCat. No.: HY-117785CAS No.: 17837-89-74’-Methoxy-α-ethylaminovalerophenone hydrochloride is structurally classified as a drug derivative.
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CD-349
0 ImagesCat. No.: HY-19047CAS No.: 88594-08-5CD-349 is an active compound.
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4-O-Methyl-ascochlorin
0 ImagesCat. No.: HY-N15121CAS No.: 38561-40-94-O-Methyl-ascochlorin (Compound MAC) is a derivative of Ascochlorin (HY-101021). 4-O-Methyl-ascochlorin can selectively induce apoptosis of K562 leukemia cells, cause G1 phase arrest and downregulate c-Myc expression. 4-O-Methyl-ascochlorin can promote the phosphorylation of AMPK and inhibit the phosphorylation of mTOR and its target proteins, including p70S6 K and 4E-BP-1. 4-O-Methyl-ascochlorin can be used for research of leukemia.
