Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4062)
Related Products (4062)
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349U85 hydrochloride
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Anticancer agent-361
0 ImagesCat. No.: HY-189261Anticancer agent-361 is a glycine-conjugated coumarin-quinazoline fused heterocyclic derivative with selective antitumor proliferation activity. Anticancer agent-361 induces G0/G1 cell cycle arrest, apoptosis, and LDH release accompanied by membrane damage. Anticancer agent-361 is predicted to be a PI3Kα/PI3Kγ inhibitor. Anticancer agent-361 can be used for research on lung cancer, pancreatic cancer, prostate cancer, and breast cancer.
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PNU-142731A
0 ImagesCat. No.: HY-19300ACAS No.: 214212-38-1PNU-142731A is an active compound.
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Antitumor agent-205
0 ImagesCat. No.: HY-177224CAS No.: 577747-87-6Antitumor agent-205 (compound 9), an Ecteinascidin derivative, is an antitumor agent. Antitumor agent-205 exhibits anti-proliferation activity against A549 and HT29 cells , with GI50 values of 16.4 nM for each cell line. Antitumor agent-205 can be used for lung and colon cancer research.
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(R)-Norverapamil
0 ImagesCat. No.: HY-117439CAS No.: 123932-43-4(R)-Norverapamil is an active compound.
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Tetrahydroswertianolin
0 ImagesCat. No.: HY-N18018CAS No.: 189289-76-7Tetrahydroswertianolin (Compound 1) is a tetrahydroxyxanthone glycoside that can be isolated from the whole plant of Swertia japonica Makino. Tetrahydroswertianolin reduces the elevated blood ALT levels in mice with immune-induced liver injury and exhibits protective activity against liver injury. Tetrahydroswertianolin can be used in studies related to anthelmintic, antipyretic and immune-induced liver injury.
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IBI352g4a
0 ImagesCat. No.: HY-P992381IBI352g4a is a humanized IgG1 monoclonal antibody targeting PVRIG (Kd = 0.53 nM) and acts as a PVRIG/PVRL2 inhibitor. The anti-tumor effect of IBI352g4a depends on the binding of its Fc region to FcγR. IBI352g4a binds to the extracellular domains of human and cynomolgus monkey PVRIG, and blocks the PVRIG-PVRL2 interaction. IBI352g4a induces NK cell activation, promotes their degranulation and tumor killing. IBI352g4a can be used in the research of gastric cancer.
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PF-244
0 ImagesCat. No.: HY-124168CAS No.: 33979-27-0PF-244 is an active compound.
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17-O-Demethylgeldanamycin
0 ImagesCat. No.: HY-N15054CAS No.: 52762-28-417-O-Demethylgeldanamycin is a secondary metabolite that can be isolated from Streptomyces. 17-O-Demethylgeldanamycin exhibits cytotoxicity against a variety of tumor cells and has anti-tumor activity.
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2-Bromobenzene-1,3,5-triol
0 ImagesCat. No.: HY-W105054CAS No.: 84743-77-12-Bromobenzene-1,3,5-triol is a brominated phloroglucinol derivative that can be found in the red alga Rhabdonia verticillata.
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UTKO1
0 ImagesCat. No.: HY-171977CAS No.: 868136-01-0UTKO1 (Compound 2) is a derivate of Moverastin.UTKO1 has optical activity and significant inhibitory activity against tumor cell migration by abrogating the binding of 14-3-3ζ/Tiam1. UTKO1 can be used for cancers like esophageal cancer and epidermoid carcinoma research.
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1-O-Caffeoyl-3,4-di-O-galloyl-β-D-glucopyranose
0 ImagesCat. No.: HY-N17165CAS No.: 359819-46-81-O-Caffeoyl-3,4-di-O-galloyl-β-D-glucopyranose is a natural phenylacetylene.
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ZK110841
0 ImagesCat. No.: HY-113812CAS No.: 105595-17-3ZK110841 is an active compound.
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U-78517 dihydrochloride
0 ImagesCat. No.: HY-164295ACAS No.: 133681-84-2U-78517 dihydrochloride, a Trolox (HY-101445) analog, is a potent antioxidant. U-78517 dihydrochloride inhibits DCVC (HY-19717)-induced lipid peroxidation, scavenges DPPH, oxygen- and nitrogen-based free radicals. U-78517 dihydrochloride attenuates hypoxic injury in iaolated cardiac myocytes. U-78517 dihydrochloride can be used for the research of hypoxic injury, cerebral ischemia, and cardiovascular disease.
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Ruixianglangdusu B
0 ImagesCat. No.: HY-N16828CAS No.: 447454-49-1Ruixianglangdusu B is a natural flavonoid.
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Cyclocalopin A
0 ImagesCat. No.: HY-N3663CAS No.: 486430-94-8Cyclocalopin A is a natural sesquiterpene.
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(S)-Desoxy-D2PM hydrochloride
0 ImagesCat. No.: HY-W072274CAS No.: 188398-87-0Synonyms: (S)-2-Diphenylmethylpyrrolidine hydrochloride(S)-Desoxy-D2PM ((S)-2-Diphenylmethylpyrrolidine) hydrochloride is a neuroactive compound.
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AHR-16303B
0 ImagesCat. No.: HY-136891CAS No.: 117023-62-8AHR-16303B is an active compound.
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Esterbut-3
0 ImagesCat. No.: HY-105414CAS No.: 125161-47-9Esterbut-3 is a potent anticancer agent. Esterbut-3 inhibits cell proliferation. Esterbut-3 decreases the antigen expression of 115D8, 140C1 and increases the antigen expression of 123C3. Esterbut-3 induces cell cycle arrest at G0/G1 phase.
