Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Inhibitors
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Drug Derivative Controls
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Drug Derivative Related Products (4062)
Related Products (4062)
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(2R,4S)-3,4-Dihydro-4-hydroxy-2,7-dimethyl-1(2H)-naphthalenone
0 ImagesCat. No.: HY-N21983CAS No.: 1932291-56-9(2R,4S)-3,4-Dihydro-4-hydroxy-2,7-dimethyl-1 (2H)-naphthalenone is a tetralone derivative found in Pyrola calliantha. It exerts extremely weak inhibitory effects on arachidonic acid-induced platelet aggregation and shows no positive inotropic activity on isolated guinea pig right atria.
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Methyl-cudratricusxanthone B
0 ImagesCat. No.: HY-186195CAS No.: 2645475-69-8Methyl-cudratricusxanthone B is a derivative of Xanthone (HY-N0126), and a derivative of Cudratricusxanthone B. Xanthone is a monoamine oxidase A (MAO-A) inhibitor with an IC50 of 0.84 µM.
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(±)-Isopaucifloral F
0 ImagesCat. No.: HY-N15473CAS No.: 1001259-00-2Synonyms: (±)-Isopauciflorol FIsopaucifloral F ((±)-Isopaucifloral F) is a Resveratrol (HY-16561)-derived sesquiterpenes. Isopaucifloral F is an orally active ERβ agonist (EC50: 46.96 μM). Isopaucifloral F has antiosteoporosis activity. LD50 in rats: > 5 mg/kg.
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5-HT4R agonist-1
0 ImagesCat. No.: HY-115774CAS No.: 2231302-46-65-HT4R agonist-1 is an active compound.
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DPP4-In
0 ImagesCat. No.: HY-103432CAS No.: 866396-34-1DPP4-In is an active compound.
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Anticancer agent 330
0 ImagesCat. No.: HY-184338CAS No.: 3127025-65-1Anticancer agent 330 is a semi-synthetic derivative of Salinomycin (HY-15597) conjugated with triphenylphosphine, as well as an anticancer agent. Anticancer agent 330 induces G0/G1 phase cell cycle arrest. Anticancer agent 330 reduces the production of ROS in cells. Anticancer agent 330 impairs mitochondrial integrity. Anticancer agent 330 promotes Autophagy. Anticancer agent 330 can be used in research related to ovarian cancer.
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Taberpsychine
0 ImagesCat. No.: HY-N16949CAS No.: 19452-84-7Taberpsychine is a natural alkaloid.
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Toddalosin ethyl ether
0 ImagesCat. No.: HY-N13843CAS No.: 1538607-31-6Toddalosin ethyl ether is a natural coumarin.
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Garcinexanthone A
0 ImagesCat. No.: HY-N3927CAS No.: 1107620-67-6Garcinexanthone A is a natural xanthone.
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2-Carene
0 ImagesCat. No.: HY-W978590CAS No.: 554-61-02-Carene is an active ingredient that can be extracted from Solanum lycopersicum. 2-Carene belongs to monoterpenoid compounds.
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CB-002
0 ImagesCat. No.: HY-122712CAS No.: 61034-15-9CB-002 is an active molecule that can be used for the study of advanced malignant solid neoplasm.
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Jasamplexoside A
0 ImagesCat. No.: HY-N9817CAS No.: 147764-93-0Jasamplexoside A is a natural iridoid.
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Tallimustine
0 ImagesCat. No.: HY-105270CAS No.: 115308-98-0Synonyms: FCE 24517Tallimustine (FCE 24517), a distamycin-A derivative, is an anticancer agent.
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Taltrimide
0 ImagesCat. No.: HY-106469CAS No.: 81428-04-8Synonyms: MY-117Taltrimide (MY-117), a lipophilic derivative of Taurine (HY-B0351), strongly inhibits the sodium-independent binding of Taurine to synaptic membranes of brain, the effects on the binding of GABA being less pronounced. Taltrimide exhibits definitive anticonvulsive effects in experimental epilepsy models.
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Dihydroepideoxyartennuin B
0 ImagesCat. No.: HY-N18335CAS No.: 104196-16-9Dihydroepideoxyartennuin B is a cadinanolide-class sesquiterpene lactone found in the aerial parts of Artemisia annua.
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Progesterone carboxylic acid
0 ImagesSynonyms: Etienic acid; Testosterone-17β-carboxylic acid; 3-Oxoandrost-4-ene-17β-carboxylic acidProgesterone carboxylic acid (Testosterone-17β-carboxylic acid) is an androstenedione analogue. Progesterone carboxylic acid can conjugate with 20-mer peptide nucleic acid (PNA) and the conjugate has superior binding capacity on complementary DNA. Progesterone carboxylic acid can be used for cancers and type 2 diabetes (T2D) research.
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Ibuprofen arginine
0 ImagesCat. No.: HY-139068CAS No.: 57469-82-6Ibuprofen arginine is an orally active L-arginine of Ibuprofen (HY-78131). With rapid absorption and high bioavailability, Ibuprofen arginine can effectively relieve a variety of acute pain, and has little damage to gastric mucosa and is well tolerated. Ibuprofen arginine can be used in research for pain relief.
