Virus Protease
Viral proteases are enzymes encoded by the genetic material (DNA or RNA) of viral pathogens. Viral proteases catalyze the cleavage of specific peptide bonds in viral polyprotein precursors or in cellular proteins. Viral proteases may use different catalytic mechanisms involving either serine, cysteine or aspartic acid residues to attack the scissile peptide bond. Selective recognition of these sequence patterns by a complementary substrate binding site of the enzyme ensures a high degree of specific recognition and cleavage.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the cause of the respiratory illness coronavirus disease 2019 (COVID-19). Initial spike protein priming by transmembrane protease, serine 2 (TMPRSS2) is essential for entry of SARS-CoV-2. After a SARS-CoV-2 virion attaches to a target cell, the cell's protease TMPRSS2 cuts open the spike protein of the virus, exposing a fusion peptide.
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Virus Protease Related Products (398)
Related Products (398)
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Antibodies (1)
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SARS-CoV-2-IN-125
0 ImagesCat. No.: HY-188127CAS No.: 60230-38-8SARS-CoV-2-IN-125 is a SARS-CoV-2 main protease (Mpro) inhibitor with an IC50 of 0.15 μM. SARS-CoV-2-IN-125 inhibits SARS-CoV-2 Mpro enzymatic activity, a component essential for viral replication. SARS-CoV-2-IN-125 can be used for the research of covid-19.
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Nsp12-IN-2
0 ImagesCat. No.: HY-174439CAS No.: 667882-55-5Nsp12-IN-2 (Compound 8), the triphosphate metabolite of 4'-thiouridine (HY-W113081), is a SARS-CoV-2 Nsp12 inhibitor. Nsp12-IN-2 inhibits the RNA-dependent RNA polymerase (RdRp) activity of the SARS-CoV-2 Nsp12-Nsp7-Nsp8 complex, terminates RNA synthesis and also blocks the RNAylation and NMPylation of Nsp9. Nsp12-IN-2 is promising for research of infections caused by SARS-CoV-2, other coronaviruses, and other RNA viruses.
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PROTAC SARS-CoV-2 Mpro degrader-5
0 ImagesCat. No.: HY-181154PROTAC SARS-CoV-2 Mpro degrader-5 is a SARS-CoV-2 main protease (Mpro) PROTAC. PROTAC SARS-CoV-2 Mpro degrader-5 engages CRBN E3 ubiquitin ligase to form a ternary complex with SARS-CoV-2 Mpro, induces K48-linked polyubiquitination of SARS-CoV-2 Mpro, and drives proteasome-dependent turnover of SARS-CoV-2 Mpro with a high selectivity index (CC50/DC50 > 10) in human embryonic kidney cells.PROTAC SARS-CoV-2 Mpro degrader-5 can be used for the research of COVID-19.
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4-Phenylbutyric acid (Standard)
0 Images4-Phenylbutyric acid (Standard) is the analytical standard of 4-Phenylbutyric acid (HY-A0281). This product is intended for research and analytical applications. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.
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SARS-CoV-2 Mpro-IN-51
0 ImagesCat. No.: HY-179102CAS No.: 2648754-84-9SARS-CoV-2 Mpro-IN-51 (compound 4) is a SARS-CoV-2 Mpro inhibitor (IC50 = 26 nM). SARS-CoV-2 Mpro-IN-51 has inhibitory effects on the triple mutant L50F/E166A/L167F. SARS-CoV-2 Mpro-IN-51 can be used for research on viral infections.
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SARS-CoV-2 PLpro-IN-1
0 ImagesCat. No.: HY-170399CAS No.: 3053753-61-7SARS-CoV-2 PLpro-IN-1 (Compound 85) is a non-covalent and competitive inhibitor of SARS-CoV-2 PLpro with an IC50 of 15.06 μM and a Ki of 22.93 μM. SARS-CoV-2 PLpro-IN-1 inhibits the proliferation of Vero cell with an IC50 of 7.47 μM.
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ent-Oseltamivir
0 ImagesCat. No.: HY-172515CAS No.: 1035895-88-5ent-Oseltamivir, the enantiomer of Oseltamivir (HY-13317), is a neuraminidase (NA) of influenza virus inhibitor. ent-Oseltamivir is promising for research of influenza virus infections.
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Phenytoin-d5
0 ImagesCat. No.: HY-B0448S2Synonyms: 5,5-Diphenylhydantoin-d5Phenytoin-d5 (5,5-Diphenylhydantoin-d5) is deuterium labeled Phenytoin. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice.
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(E)-3,4-Dimethoxycinnamic acid (Standard)
0 ImagesSynonyms: (E)-O-Methylferulic acid (Standard)(E)-3,4-Dimethoxycinnamic acid is the less active isomer of 3,4-Dimethoxycinnamic acid. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway. Anti-apoptotic effects.
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UAWJ9-36-3
0 ImagesCat. No.: HY-178696CAS No.: 2663864-31-9UAWJ9-36-3 is a Mpro and cathepsin L (IC50: 1.81 μM) inhibitor. UAWJ9-36-3 shows potent binding and enzymatic inhibition against the Mpros from SARS-CoV-2, SARS-CoV, MERS-CoV, HCoV-OC43, HCoV-NL63, HCoV-229E, and HCoV-HKU1. UAWJ9-36-3 demonstrates broad-spectrum antiviral activity against not only SARS-CoV-2, but also the common human coronaviruses HCoV-OC43, HCoV-NL63, and HCoV-229E.
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PRRSV-IN-1
0 ImagesCat. No.: HY-173199CAS No.: 801220-43-9PRRSV-IN-1 (Compound 4s) is a nsp4 protease inhibitor targeting PRRSV, exhibiting an EC50 of 0.45 μM against PRRSV. It binds to the nsp4 protease with a Kd value of 29.24 pM and inhibits nsp4 protease activity with an IC50 of 80.36 pM. PRRSV-IN-1 can be used for research in the field of antiviral infections.
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VCH-916 free base
0 ImagesCat. No.: HY-13465ACAS No.: 914778-92-0VCH-916 free base is a thiophene derivative and non-nucleoside inhibitor of HCV NS5B polymerase. VCH-916 free base binds to Thumb Site II. VCH-916 free base can be used for the research of hepatitis c virus (hcv) infection.
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MI-23
0 ImagesCat. No.: HY-182425CAS No.: 2698348-90-0MI-23 is a SARS-CoV-2 main protease (SARS-CoV-2 Mpro) inhibitor with an IC50 of 7.6 nM. MI-23 is applicable to the research of COVID-19.
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(S)-ML188
0 ImagesCat. No.: HY-W614623CAS No.: 1417700-12-9(S)-ML188 is a SARS-CoV 3-chymotrypsin-like protease (3CLpro) inhibitor (IC50: 1.5 μM). (S)-ML188 has antiviral activity with an EC50 value of 12.9 μM against SARS-CoV. (S)-ML188 inhibits the activity of 3CLpro via non-covalent binding and can be used in the study of SARS-CoV.
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Tubacin (Standard)
0 ImagesCat. No.: HY-13428RCAS No.: 537049-40-4Tubacin (Standard) is the analytical standard of Tubacin. This product is intended for research and analytical applications. Tubacin is a potent and selective inhibitor of HDAC6, with an IC50 value of 4 nM and approximately 350-fold selectivity over HDAC1. Tubacin also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2).
