1. GPCR/G Protein Neuronal Signaling
  2. Adrenergic Receptor
  3. Abanoquil

Abanoquil  (Synonyms: U-K52046; Albanoquil)

Cat. No.: HY-106612 Purity: 98.43%
COA Handling Instructions

Abanoquil (U-K52046), an potent and selective α-1 adrenoceptor antagonist, is an anti-arrhythmic agent. Abanoquil can be used for erectile dysfunction research.

For research use only. We do not sell to patients.

Abanoquil Chemical Structure

Abanoquil Chemical Structure

CAS No. : 90402-40-7

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Based on 1 publication(s) in Google Scholar

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Description

Abanoquil (U-K52046), an potent and selective α-1 adrenoceptor antagonist, is an anti-arrhythmic agent. Abanoquil can be used for erectile dysfunction research[1][2].

IC50 & Target[1]

α1-adrenergic receptor

 

In Vivo

Abanoquil is able to relax contracted tissue strips and induce erectile response when injected intracorporally in vivo monkey model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

395.45

Formula

C22H25N3O4

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

NC1=CC(N2CC3=CC(OC)=C(OC)C=C3CC2)=NC4=CC(OC)=C(OC)C=C14

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (31.61 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5288 mL 12.6438 mL 25.2876 mL
5 mM 0.5058 mL 2.5288 mL 5.0575 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5288 mL 12.6438 mL 25.2876 mL 63.2191 mL
5 mM 0.5058 mL 2.5288 mL 5.0575 mL 12.6438 mL
10 mM 0.2529 mL 1.2644 mL 2.5288 mL 6.3219 mL
15 mM 0.1686 mL 0.8429 mL 1.6858 mL 4.2146 mL
20 mM 0.1264 mL 0.6322 mL 1.2644 mL 3.1610 mL
25 mM 0.1012 mL 0.5058 mL 1.0115 mL 2.5288 mL
30 mM 0.0843 mL 0.4215 mL 0.8429 mL 2.1073 mL
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Abanoquil Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Abanoquil
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HY-106612
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