2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. AChE/BuChE-IN-8

AChE/BuChE-IN-8 is a dual AChE and BuChE inhibitor, with an AChE IC50 of 1.18 μM, a human AChE Ki of 1.2 μM, and a BuChE IC50 of 2.34 μM. AChE/BuChE-IN-8 acts as an antiproliferative agent and antioxidant, exerts antiproliferative effects on colon cancer cells, scavenges free radicals, and exhibits reducing power. AChE/BuChE-IN-8 can be used in the research of Alzheimer's disease and colorectal adenocarcinoma.

For research use only. We do not sell to patients.

AChE/BuChE-IN-8

AChE/BuChE-IN-8 Chemical Structure

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AChE/BuChE-IN-8 Related Antibodies

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Description

AChE/BuChE-IN-8 is a dual AChE and BuChE inhibitor, with an AChE IC50 of 1.18 μM, a human AChE Ki of 1.2 μM, and a BuChE IC50 of 2.34 μM. AChE/BuChE-IN-8 acts as an antiproliferative agent and antioxidant, exerts antiproliferative effects on colon cancer cells, scavenges free radicals, and exhibits reducing power. AChE/BuChE-IN-8 can be used in the research of Alzheimer's disease and colorectal adenocarcinoma[1].

IC50 & Target[1]

AChE

1.18 μM (IC50)

AChE

1.2 μM (Ki)

BuChE

2.34 μM (IC50)

In Vitro

AChE/BuChE-IN-8 (Compound 6d) is a mixed-type hAChE inhibitor that binds to both free enzyme and enzyme-substrate complex simultaneously. It exhibits an AChE IC50 of 1.18 μM and a BuChE IC50 of 2.34 μM, with synergistic competitive (Ki = 1.2 μM) and non-competitive (Ki' = 2.5 μM) inhibitory effects[1].
AChE/BuChE-IN-8 (48 h) exhibits moderate antiproliferative activity against Caco-2 colon cancer cells (IC50 = 4.37 μM), with a selectivity index of 7.43[1].
AChE/BuChE-IN-8 exhibits potent free radical scavenging activity (IC50 = 12.1 μM).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AChE/BuChE-IN-8 Related Antibodies
Molecular Weight

460.44

Formula

C24H18F2N6O2
SMILES

FC1=CC=C(N2C=C(COC3=CC=C(OCC4=CN(C5=CC=C(F)C=C5)N=N4)C=C3)N=N2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AChE/BuChE-IN-8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE/BuChE-IN-8Cholinesterase (ChE)AChE and BuChE inhibitorAlzheimer's disease and colorectal adenocarcinomaCaco-2 cells
Inhibitorinhibitorinhibit

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