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Cat. No.: HY-189483

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AChE/BuChE-IN-9

AChE/BuChE-IN-9 is a dual Cholinesterase inhibitor that acts on electric eel acetylcholinesterase (AChE) (IC₅₀ = 14.82 μM) and horse serum butyrylcholinesterase (IC₅₀ = 27.91 μM) through non-competitive and mixed-mode inhibition, respectively. AChE/BuChE-IN-9 can be used for research on Alzheimer's disease.

For research use only. We do not sell to patients.

Formula: C₁₈H₂₀N₂O₄
Molecular Weight:328.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AChE/BuChE-IN-9 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (2)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

AChE

14.82 μM (IC₅₀)

BuChE

27.91 μM (IC₅₀)

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vitro

AChE/BuChE-IN-9 (62.5-1000 μM; 15 min) effectively inhibits AChE (IC₅₀ = 14.82 μM) and BuChE (IC₅₀ = 27.91 μM)^[1].
AChE/BuChE-IN-9 acts as a non-competitive inhibitor of AChE (K_i = 1.522 μM) and a mixed-type inhibitor of BuChE (K_i = 0.6550 μM)^[1].
AChE/BuChE-IN-9 possesses the optimal HOMO-LUMO energy gap (4.287 eV) and a moderate electrophilicity index (2.923 eV), which correlate with its cholinesterase inhibitory activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

Molecular Weight 328.36
Formula C₁₈H₂₀N₂O₄
SMILES

OC1=CC=C(/C(C)=N\N=C\C2=CC(OC)=C(OC)C(OC)=C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology Animals and Diseases

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Daud M, et al. Synthesis of 4-Hydroxyacetophenone-Derived Bis-Schiff Bases as Potent Cholinesterase Inhibitors: In Vitro Evaluation, Molecular Docking, DFT, and ADMET Analysis. Chemistry & biodiversity. 2026 Aug;23(8):e71630.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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