Adenoregulin
Adenoregulin (Dermaseptin b2) is an antimicrobial peptide antibiotic. Adenoregulin is active against Gram-negative and Gram-positive bacteria, yeast and fungi. Adenoregulin also enhances the binding of agonists to the A1 adenosine receptor.
For research use only. We do not sell to patients.
- CAS No.: 149260-68-4
- Formula: C142H242N40O42
- Molecular Weight:3181.68
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
149260-68-4
Chemical Information
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CAS No. 149260-68-4
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Molecular Weight 3181.68
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Formula C142H242N40O42
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Synonyms
Dermaseptin b2
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Sequence
Gly-Leu-Trp-Ser-Lys-Ile-Lys-Glu-Val-Gly-Lys-Glu-Ala-Ala-Lys-Ala-Ala-Ala-Lys-Ala-Ala-Gly-Lys-Ala-Ala-Leu-Gly-Ala-Val-Ser-Glu-Ala-Val
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Sequence Shortening
GLWSKIKEVGKEAAKAAAKAAGKAALGAVSEAV
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Structure Classification
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Initial Source
frog
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
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Gram Staining of Tissue Sections
Gram staining of tissue sections is a histochemical technique used to differentiate Gram-positive and Gram-negative bacteria within histological specimens based on differences in bacterial cell wall structure and dye retention, adapted from classical bacteriological Gram staining into tissue-compatible “histological Gram stain” variants. In tissue applications, modifications of the Brown-Hopps and Brown-Brenn methods are commonly used to improve differentiation of microorganisms embedded within host connective tissue and to reduce overstaining or loss of Gram-negative signal, which are known limitations of earlier approaches. The principle relies on crystal violet-iodine complex retention in Gram-positive organisms and subsequent decolorization and counterstaining steps that allow contrast visualization of Gram-negative organisms against tissue background.
Purity & Documentation
References
[1]. Mor A, et al. Isolation and structure of novel defensive peptides from frog skin. Eur J Biochem. 1994 Jan 15;219(1-2):145-54. [Content Brief]
[2]. Baek HJ, et al. Ligand binding inhibitors of A1 adenosine receptor from Rana rugosa are phospholipase A2s. Eur J Biochem. 2000 Mar;267(5):1340-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Adenoregulin Related Classifications
HY-P5708 Related Classifications
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