2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. AGH-194

AGH-194 is a 5-HT7 receptor agonist with a Ki value of 2 nM. AGH-194 activates Gs protein-coupled signaling pathways associated with neuroprotection and neurite outgrowth, and stimulates neurite outgrowth in neuronal cells. AGH-194 reduces cell damage in undifferentiated neuronal cells. AGH-194 can be used in the research of neurodegenerative diseases.

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AGH-194

AGH-194 Chemical Structure

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AGH-194 Related Antibodies

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Description

AGH-194 is a 5-HT7 receptor agonist with a Ki value of 2 nM. AGH-194 activates Gs protein-coupled signaling pathways associated with neuroprotection and neurite outgrowth, and stimulates neurite outgrowth in neuronal cells. AGH-194 reduces cell damage in undifferentiated neuronal cells. AGH-194 can be used in the research of neurodegenerative diseases[1].

IC50 & Target[1]

5-HT7 Receptor

2 nM (Ki)

In Vitro

AGH-194 (0.1-80 μM; 24-48 h) induces concentration- and time-dependent cytotoxicity and reduced cell viability in UN-SH-SY5Y cells cultured in DMEM, with maximal effects at concentrations ≥40 μM[1].
AGH-194 (0.01-1 μM; 30 min pre-incubation, 24 h co-incubation with H2O2) at 0.1 μM partially reduces cytotoxicity but not cell viability loss in UN-SH-SY5Y cells cultured in NB exposed to H2O2-induced damage[1].
AGH-194 (0.01-0.1 μM; 24 h) stimulates neurite outgrowth in SH-SY5Y cells after 24 h, with no significant effects observed after 48 h[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AGH-194 Related Antibodies

Cell Viability Assay[1]

Cell Line: Undifferentiated human neuroblastoma UN-SH-SY5Y cells (DMEM experimental medium)
Concentration: 0.1, 1, 10, 20, 40, 80 μM
Incubation Time: 24 h, 48 h
Result: Caused a concentration- and time-dependent decrease in cell viability, with maximum damage observed at 40 and 80 μM; viability was more reduced at 48 h than 24 h for 20 and 40 μM.
Increased LDH release ~2-4-fold at 40 and 80 μM after 24 h.
Increased LDH release ~1.5-3-fold at 10, 20, 40, 80 μM after 48 h.
Showed higher LDH release at 48 h than 24 h for 20 and 40 μM, but higher at 24 h than 48 h for 80 μM.

Cell Viability Assay[1]

Cell Line: Undifferentiated human neuroblastoma UN-SH-SY5Y cells, retinoic acid-differentiated RA-SH-SY5Y cells (NB experimental medium)
Concentration: 1-20 μM
Incubation Time: 24 h
Result: Caused a significant ~18% decrease in cell viability at 20 μM in UN-SH-SY5Y cells.
Caused a significant ~15.7% decrease in cell viability at 10 μM in RA-SH-SY5Y cells.
Caused a significant ~22.95% decrease in cell viability at 20 μM in RA-SH-SY5Y cells.

Cell Proliferation Assay[1]

Cell Line: Human neuroblastoma SH-SY5Y cells (DMEM with 10% FBS)
Concentration: 0.001, 0.01, 0.1, 1, 10, 20, 40, 80 μM
Incubation Time: 24 h, 48 h, 72 h
Result: Caused a time- and concentration-dependent reduction in cell viability.
Induced maximal cell damage at 80 μM after 24 h, with similar effects at 48 and 72 h.
Caused concentration-dependent decreases in cell viability (up to ~20%) at 10, 20, 40 μM at 48 h, with greater effects than at 24 h.
Caused a significantly greater reduction in cell viability at 40 μM at 72 h than at 48 h.
Molecular Weight

377.58

Formula

C12H10ClFIN3
SMILES

FC1=C2C(NC=C2C3=C[NH+]=CN3C)=CC=C1I.[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AGH-194 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AGH-194AGH194AGH 1945-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT7 receptor agonistSH-SY5Y cellsneurodegenerative diseasesInhibitorinhibitorinhibit

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