2. Cell Cycle/DNA Damage
  3. CDK
  4. AGM-130

AGM-130 is a cyclin-dependent kinase (CDK) inhibitor. AGM-130 exhibits antitumor activity.

For research use only. We do not sell to patients.

AGM-130

AGM-130 Chemical Structure

CAS No. : 1459216-10-4

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AGM-130 Related Antibodies

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Description

AGM-130 is a cyclin-dependent kinase (CDK) inhibitor. AGM-130 exhibits antitumor activity[1].

Cellular Effect
Cell Line Type Value Description References
K-562R IC50
783 nM
Compound: 27
Antiproliferative activity against imatinib-resistant human K-562R cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Antiproliferative activity against imatinib-resistant human K-562R cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
[PMID: 34161865]
K562 IC50
669 nM
Compound: 27
Antiproliferative activity against human K562 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Antiproliferative activity against human K562 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
[PMID: 34161865]
K562 IC50
669 nM
Compound: AGM-130
Antiproliferative activity against wild type human K562 cells
Antiproliferative activity against wild type human K562 cells
[PMID: 31477350]
Molecular Weight

338.27

Formula

C16H10N4O5
CAS No.
SMILES

O=C(N1)/C(C2=C1C=CC([N+]([O-])=O)=C2)=C3/C(C(C=C(O)C=C4)=C4N3)=N/O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AGM-130 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AGM-1301459216-10-4AGM130AGM 130CDKCyclin dependent kinasecyclin-dependent kinasecancertumorInhibitorinhibitorinhibit

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