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Cat. No.: HY-114248

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AGM-130

AGM-130 is a cyclin-dependent kinase (CDK) inhibitor. AGM-130 exhibits antitumor activity.

For research use only. We do not sell to patients.

CAS No.: 1459216-10-4
Formula: C₁₆H₁₀N₄O₅
Molecular Weight:338.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

AGM-130 Chemical Structure

CAS No.: 1459216-10-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

AGM-130 is a cyclin-dependent kinase (CDK) inhibitor. AGM-130 exhibits antitumor activity^[1].

All CDK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
K562	IC₅₀	669 nM Compound: 27	Antiproliferative activity against human K562 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 34161865]
K562	IC₅₀	669 nM Compound: AGM-130	Antiproliferative activity against wild type human K562 cells Antiproliferative activity against wild type human K562 cells	[PMID: 31477350]
K-562R	IC₅₀	783 nM Compound: 27	Antiproliferative activity against imatinib-resistant human K-562R cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Antiproliferative activity against imatinib-resistant human K-562R cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 34161865]

Chemical Information

CAS No. 1459216-10-4
Molecular Weight 338.27
Formula C₁₆H₁₀N₄O₅
SMILES

O=C(N1)/C(C2=C1C=CC([N+]([O-])=O)=C2)=C3/C(C(C=C(O)C=C4)=C4N3)=N/O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Park WS, et al. Human microdosing and mice xenograft data of AGM-130 applied to estimate efficacious doses in patients. Cancer Chemother Pharmacol. 2017 Aug;80(2):363-369. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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AGM-130

All CDK Isoforms