AKT1 ligand-1
AKT1 ligand-1 is an AKT1 ligand. AKT1 ligand-1 exhibits anticancer activity against prostate cancer, lung cancer, and breast cancer.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C21H23ClN4O2S
- Molecular Weight:430.95
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
Akt1 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PC-3 | IC50 |
16.12 μM
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Cytotoxicity against human PC3 prostate adenocarcinoma cells measured by MTT assay after 24 hrs incubation.
Cytotoxicity against human PC3 prostate adenocarcinoma cells measured by MTT assay after 24 hrs incubation.
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s41598-026-67079-8 |
| A549 | IC50 |
26.36 μM
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Cytotoxicity against human A549 lung carcinoma cells measured by MTT assay after 24 hrs incubation.
Cytotoxicity against human A549 lung carcinoma cells measured by MTT assay after 24 hrs incubation.
|
s41598-026-67079-8 |
| MCF7 | IC50 |
19.12 μM
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Cytotoxicity against human MCF-7 breast adenocarcinoma cells measured by MTT assay after 24 hrs incubation.
Cytotoxicity against human MCF-7 breast adenocarcinoma cells measured by MTT assay after 24 hrs incubation.
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s41598-026-67079-8 |
In Vitro
AKT1 ligand-1 (Compound 4b) (6.25-100 µM; 24 h) exhibits MTT cytotoxicity against PC3, A549, and MCF-7 cancer cell lines, with IC50 values of 16.12, 26.36, and 19.12 µM, respectively, showing the strongest activity against PC3 prostate adenocarcinoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC3, A549, and MCF-7 human cancer cell lines
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Concentration:6.25-100 µM
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Incubation Time:24 h
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Result:IC50 values for AKT1 ligand-1 (compound 4b) were 16.12 µM against PC3, 26.36 µM against A549, and 19.12 µM against MCF-7.
AKT1 ligand-1 (compound 4b) showed 1.6-fold higher potency against PC3 compared with A549.
Chemical Information
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Molecular Weight 430.95
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Formel C21H23ClN4O2S
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SMILES
C=C([C@@H]1CC=C(/C(C1)=N/N=C2SC(C(OCC)=O)=NN/2C3=CC=C(C=C3)Cl)C)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
AKT1 ligand-1 Related Classifications
HY-189728 Related Classifications
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