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Cat. No.: HY-190681

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alpha-Mangostin-C2-morpholine

Name: alpha-Mangostin-C2-morpholine
Brand: MedChemExpress
SKU: HY-190681
Availability: PreOrder

(Synonyms: α-Mangostin-C2-morpholine)

alpha-Mangostin-C2-morpholine (α-Mangostin-C2-morpholine) is a selective AChE inhibitor with an IC₅₀ of 0.11 μM. alpha-Mangostin-C2-morpholine binds Aβ and inhibits self-induced aggregation and AChE-induced aggregation. alpha-Mangostin-C2-morpholine exhibits hydroxyl radical scavenging activity with an IC₅₀ of 0.19 μM, and reduces ROS levels in C. elegans in vivo. alpha-Mangostin-C2-morpholine can be used for research on Alzheimer's disease.

For research use only. We do not sell to patients.

Formula: C₃₀H₃₇NO₇
Molecular Weight:523.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (281 KB)

alpha-Mangostin-C2-morpholine Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

AChE

0.11 μM (IC₅₀)

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vitro

Aβ/Tau/α-Synuclein AggregationOxidative StressOthers

Aβ/Tau/α-Synuclein Aggregation

alpha-Mangostin-C2-morpholine inhibits self-induced and AChE-induced Aβ aggregation, with inhibition rates of 53.8% and 57.3%, respectively^[1].

Oxidative Stress

alpha‑Mangostin‑C2‑morpholine shows an ORAC value of 0.53 Trolox equivalents^[1].

alpha-Mangostin-C2-morpholine neutralizes ⋅O₂⁻ through electron transfer^[1].

Others

alpha-Mangostin-C2-morpholine (compound 1) inhibits AChE with an IC₅₀ of 0.11 μM and exhibits 59.27-fold selectivity over BuChE (IC₅₀ of 6.52 μM); it scavenges ⋅OH with an IC₅₀ of 0.19 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Oxidative Stress

alpha-Mangostin-C2-morpholine (compound 1) (24 h) reduces ROS levels by approximately 48% in Caenorhabditis elegans^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

Molecular Weight 523.62
Formula C₃₀H₃₇NO₇
SMILES

OC(C(C/C=C(C)/C)=C1O)=CC2=C1C(C3=C(C/C=C(C)/C)C(OC)=C(OCCN4CCOCC4)C=C3O2)=O
Synonyms

α-Mangostin-C2-morpholine
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang B, et al. Semi-synthesis and activity study of α-mangostin ether derivatives bearing N-heterocyclic side chains as multitarget-directed ligands against AD. Bioorganic & medicinal chemistry letters. 2027 Jan;142:130758. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

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100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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alpha-Mangostin-C2-morpholine

All Cholinesterase (ChE) Isoforms