1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Microtubule/Tubulin
  3. Anticancer agent 48

Anticancer agent 48 

Cat. No.: HY-146357
Handling Instructions

Anticancer agent 48 (compound 48) is a broad spectrum anticancer agent. Anticancer agent 48 inhibits tubulin polymerization. Anticancer agent 48 shows antiproliferative activity. Anticancer agent 48 shows antitumor activity in vivo. Anticancer agent 48 has the potential for the research of solid and hematological tumors.

For research use only. We do not sell to patients.

Anticancer agent 48 Chemical Structure

Anticancer agent 48 Chemical Structure

CAS No. : 2395009-13-7

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Description

Anticancer agent 48 (compound 48) is a broad spectrum anticancer agent. Anticancer agent 48 inhibits tubulin polymerization. Anticancer agent 48 shows antiproliferative activity. Anticancer agent 48 shows antitumor activity in vivo. Anticancer agent 48 has the potential for the research of solid and hematological tumors[1].

In Vitro

Anticancer agent 48 (compound 48) inhibits tubulin polymerization and MCF-7 cancer cell growth with IC50s of 0.47 µM and 14 nM, respectively[1].
Anticancer agent 48 shows antiproliferative activity with IC50s of 8, 10, 12, 14, 16 nM for KU812, LAMA84-S, LAMA84-R, KBM5-WT, KBM5-T315I cells, respectively[1].
Anticancer agent 48 shows growth inhibition with IC50s of 12, 31, 37, 221, 56, 27, 51, 48, 28, 12 nM for U343G, U87MG, T98G, SK-N-BE, SK-N-BE(2)-C, HT29, HCT116, SW480, SW620, T24 cell, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anticancer agent 48 (20 mg/kg; i.p.; every 2 days for 40 days) shows antitumor effects[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8 week-old female BALB/Cnu/nu mice (EZ-2 or T24 cells)[1]
Dosage: 20 mg/kg
Administration: I.p.; every 2 days for 40 days
Result: Significantly inhibited cancer cell proliferation, in vivo tumorigenesis, and tumor angiogenesis.
Molecular Weight

443.49

Formula

C26H25N3O4

CAS No.
SMILES

COC1=CC(C(C2=CN(C=C2C3=CC=C(C=C3)N)C4=CC=CC(N)=C4)=O)=CC(OC)=C1OC

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Anticancer agent 48
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