Antileishmanial agent-18
Antileishmanial agent-18 (Compound 1e) is an antileishmanial agent. Antileishmanial agent-18 effectively inhibits growth of L. donovani promastigotes. Antileishmanial agent-18 is safe for host cells.
For research use only. We do not sell to patients.
- CAS No.: 1007567-02-3
- Formula: C28H27N3O4
- Molecular Weight:469.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Parasite Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | CC50 |
>200 μM
Compound: 1e
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Cytotoxicity against human HEK293T cells assessed as cell death by measuring metabolism of resazurin to resorufin measured after 3 days
Cytotoxicity against human HEK293T cells assessed as cell death by measuring metabolism of resazurin to resorufin measured after 3 days
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[PMID: 36827952] |
| THP-1 | CC50 |
93 μM
Compound: 1e
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Cytotoxicity against human THP-1 cells assessed as cell death by measuring metabolism of resazurin to resorufin measured after 3 days
Cytotoxicity against human THP-1 cells assessed as cell death by measuring metabolism of resazurin to resorufin measured after 3 days
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[PMID: 36827952] |
Chemical Information
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CAS No. 1007567-02-3
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Molecular Weight 469.53
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Formula C28H27N3O4
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SMILES
CC1=C(NC2=CC=CC=C2C1=O)C(N[C@H]([C@H](C(NCC3=CC=CC=C3)=O)O)CC4=CC=CC=C4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Hassan AHE, et al. Bestatin analogs-4-quinolinone hybrids as antileishmanial hits: Design, repurposing rational, synthesis, in vitro and in silico studies. Eur J Med Chem. 2023 Mar 15;250:115211. [Content Brief]
[2]. Hassan AHE, et, al. Bestatin analogs-4-quinolinone hybrids as antileishmanial hits: Design, repurposing rational, synthesis, in vitro and in silico studies. Eur J Med Chem. 2023 Mar 15;250:115211. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antileishmanial agent-18 Related Classifications
HY-149834 Related Classifications
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