1. Anti-infection
  2. SARS-CoV Bacterial
  3. Antimicrobial agent-10

Antimicrobial agent-10 is a SARS-CoV-2 inhibitor with outstanding antibacterial activity.

For research use only. We do not sell to patients.

Antimicrobial agent-10 Chemical Structure

Antimicrobial agent-10 Chemical Structure

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Description

Antimicrobial agent-10 is a SARS-CoV-2 inhibitor with outstanding antibacterial activity[1].

IC50 & Target

Bacteria, SARS-CoV-2[1]

In Vitro

Antimicrobial agent-10 (compound 4) shows inhibitory activity on coronavirus (SARS-CoV-2, HCoV-229E) replication and spike-mediated pseudovirus entry in Vero E6 cells, Calu-3 cells, A549-AT cells, with EC50 values of 13-22 μM[1].
Antimicrobial agent-10 inhibits cathepsin L, 3CLPro enzyme activity and the ACE2-spike interaction, with EC50 values of 66 μM, 7.6 μM, 9 μM respectively[1].
Antimicrobial agent-10 (0-10 μg/mL approximately) shows activity against diverse species of Gram-positive bacteria including drug-resistant strains[1].
Antimicrobial agent-10 (0-100 μM, 2 h) inhibits SARS-CoV-2 pseudovirus entry in Vero and A549-AT cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: S. aureus, E. faecalis, E. faecium, S. epidermidis, S. haemolyticus
Concentration: 0-10 μg/mL approximately
Incubation Time:
Result: Inhibited bacteria activities with MIC values of 0.25-6.8 μg/mL.
Molecular Weight

1844.29

Formula

C78H65Cl2F13N10O24

SMILES

OC1=C(OC2=C(C=C(C=C2)[C@@]([H])(O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)NC(C)=O)[C@]([H])(NC([C@@H]4N5)=O)C(N[C@H](C6=CC(O)=CC(O)=C6C7=CC4=CC=C7O)C(O)=O)=O)Cl)C=C(C=C1OC8=C(C=C(C=C8)C[C@]([H])9NC([C@@H]%10N%11N=NC(COCCCC(F)(C(F)(C(F)(C(F)(F)C(F)(C(F)(F)F)F)F)F)F)=C%11)=O)Cl)[C@H](C5=O)NC([C@@H](NC9=O)C%12=CC(OC%13=CC%10=CC=C%13O)=CC(O)=C%12)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Antimicrobial agent-10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Antimicrobial agent-10
Cat. No.:
HY-151497
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