Antimicrobial agent-10
Antimicrobial agent-10 is a SARS-CoV-2 inhibitor with outstanding antibacterial activity.
For research use only. We do not sell to patients.
- Formula: C78H65Cl2F13N10O24
- Molecular Weight:1844.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Bacteria, SARS-CoV-2[1]
Antimicrobial agent-10 (compound 4) shows inhibitory activity on coronavirus (SARS-CoV-2, HCoV-229E) replication and spike-mediated pseudovirus entry in Vero E6 cells, Calu-3 cells, A549-AT cells, with EC50 values of 13-22 μM[1].
Antimicrobial agent-10 inhibits cathepsin L, 3CLPro enzyme activity and the ACE2-spike interaction, with EC50 values of 66 μM, 7.6 μM, 9 μM respectively[1].
Antimicrobial agent-10 (0-10 μg/mL approximately) shows activity against diverse species of Gram-positive bacteria including drug-resistant strains[1].
Antimicrobial agent-10 (0-100 μM, 2 h) inhibits SARS-CoV-2 pseudovirus entry in Vero and A549-AT cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:S. aureus, E. faecalis, E. faecium, S. epidermidis, S. haemolyticus
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Concentration:0-10 μg/mL approximately
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Incubation Time:
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Result:Inhibited bacteria activities with MIC values of 0.25-6.8 μg/mL.
Chemical Information
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Molecular Weight 1844.29
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Formula C78H65Cl2F13N10O24
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SMILES
OC1=C(OC2=C(C=C(C=C2)[C@@]([H])(O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)NC(C)=O)[C@]([H])(NC([C@@H]4N5)=O)C(N[C@H](C6=CC(O)=CC(O)=C6C7=CC4=CC=C7O)C(O)=O)=O)Cl)C=C(C=C1OC8=C(C=C(C=C8)C[C@]([H])9NC([C@@H]%10N%11N=NC(COCCCC(F)(C(F)(C(F)(C(F)(F)C(F)(C(F)(F)F)F)F)F)F)=C%11)=O)Cl)[C@H](C5=O)NC([C@@H](NC9=O)C%12=CC(OC%13=CC%10=CC=C%13O)=CC(O)=C%12)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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