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Cat. No.: HY-158018

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EGFR-TK-IN-2

EGFR-TK-IN-2 (compound 10b) is EGFR-TK inhibitor with the IC₅₀ of 0.16 μM. EGFR-TK-IN-2 inhibits cell growth.

For research use only. We do not sell to patients.

Formula: C₂₂H₁₉N₃O₃
Molecular Weight:373.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

EGFR-TK-IN-2 Chemical Structure

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

EGFR-TK-IN-2 (compound 10b) is EGFR-TK inhibitor with the IC₅₀ of 0.16 μM. EGFR-TK-IN-2 inhibits cell growth^[1].

All EGFR Isoforms :

In Vitro

EGFR-TK-IN-2 (compound 10b) inhibits cell growth with the IC₅₀ values of 9.94 μM, 6.32 μM and 8.11 μM aganist HCT116, HePG-2 and MCF7, respectively.^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 373.40
Formula C₂₂H₁₉N₃O₃
SMILES

O=[N+](C1=CC(C2CC(C3=CC=C(OCC4=CC=CC=C4)C=C3)=NN2)=CC=C1)[O-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Serag MI, et al. M. New oxadiazole and pyrazoline derivatives as anti-proliferative agents targeting EGFR-TK: design, synthesis, biological evaluation and molecular docking study. Sci Rep. 2024;14(1):5474. Published 2024 Mar 5. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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EGFR-TK-IN-2

All EGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

EGFR-TK-IN-2 Related Classifications

HY-158018 Related Classifications