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Cat. No.: HY-188395

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Antiproliferative agent-86

Name: Antiproliferative agent-86
Brand: MedChemExpress
SKU: HY-188395
Price: 400.00 USD
Availability: InStock
Rating: 5 (1 reviews)

Antiproliferative agent-86 is an antiproliferative agent that inhibits HeLa cell proliferation. Antiproliferative agent-86 binds ATR with a IC₅₀ of 6.02 nM under tracer A conditions. Antiproliferative agent-86 can be used in cancer-related research.

For research use only. We do not sell to patients.

CAS No.: 2111193-51-0
Formula: C₂₁H₂₃N₇O
Molecular Weight:389.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (288 KB)

Antiproliferative agent-86 Chemical Structure

CAS No.: 2111193-51-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

IC₅₀ & Target

^[1]

ATR

6.02 nM (IC₅₀)

All ATM/ATR Isoforms :

In Vitro

Anti-cancer

Antiproliferative agent-86 (Example 2) exhibits an ATR binding IC₅₀ of 6.02 nM under tracer A conditions and also inhibits HeLa cell proliferation with a corresponding IC₅₀ of 63.4 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 2111193-51-0
Molecular Weight 389.45
Formula C₂₁H₂₃N₇O
SMILES

CC1=CN=C(C2=NNC=C2)C3=C1C(C4=CC=NN4C)=CC(N5[C@@H](COCC5)C)=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (288 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. LÜCKING U, et al. 5-substituted 2-(morpholin-4-yl)-1,7-naphthyridines. WO2017121684A1, 2017.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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