Art. -Nr.: HY-109506

DPPC

(Synonyms: 129Y83)

10 Cited Publications

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Based on 10 publication(s) in Google Scholar

DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice.

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Reinheit: 99.91%
CAS. Nr.: 63-89-8
Formel: C₄₀H₈₀NO₈P
Molecular Weight:734.04

Speicherung:

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

DPPC Chemical Structure

CAS. Nr.: 63-89-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (10)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Human Endogenous Metabolite

Microbial Metabolite

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

In Vitro

DPPC (2-10 mg/ml) monolayer can be inserted by Aβ40, but the amount of insertion is smaller than that of DPPG or DPTAP. The behavior of Aβ40 inserted into the DPPC monolayer is affected by surface pressure, solvent (water or PBS), and salt concentration^[3].
DPPC can mix with DPPE to form DPPC/DPPE lipid bilayer systems. As DPPE concentration rises, the average area per headgroup diminishes (0.65 to 0.52 nm²), enhancing membrane compactness. Meanwhile, membrane thickness slightly increases (3.43 to 4.00 nm), reflecting lipid tail ordering. ^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DPPC（0.5 μmol, 7 days) can serve as a critical component that enhances the stability of lipid membrane structures in liposome construction. GSL antigen was virtually non-immunogenic by itself, but GSL antigen-containing DMPC-liposome can enhance the immunogenicity of GSL antigen in mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female BALB/c mice (6-week-old)
Dosage:

0.05 μmol
Administration:

Intraperitoneally immunized
Result:

DPPC-liposome would serve effectively as a delivery vehicle for inducing immune responses against GSL antigen. DPPC-liposome combined with GSL antigens was more effective than GSLs reconstituted in either DMPC- or DSPC-liposome ^[2].

Chemical Information

CAS. Nr. 63-89-8
Appearance Solid
Molecular Weight 734.04
Formel C₄₀H₈₀NO₈P
Color White to off-white
SMILES

CCCCCCCCCCCCCCCC(O[C@H](COC(CCCCCCCCCCCCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O)=O
Synonyms

129Y83
Initial Source
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (10)

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Journal Impact Factor

Adv Sci (Weinh)

CircUGP2 Suppresses Intrahepatic Cholangiocarcinoma Progression via p53 Signaling Through Interacting With PURB to Regulate ADGRB1 Transcription and Sponging miR-3191-5p. [Abstract]

2024 Oct;11(38):e2402329. PMID: 39120980
Asian J Pharm Sci

A programmable nanoreactor for photothermal immunotherapy via NIR-II triggered enzyme-catalyzed immunogenic tumor microenvironment remodeling. [Abstract]

2026 Apr;21(2):101150. PMID: 42023164
Chem Eng J

2025 Sep 9.
Nano Today

2021, 101151.
J Agric Food Chem

Understanding the Transepithelial Transport and Transbilayer Diffusion of the Antihypertensive Peptide Asn-Cys-Trp: Insights from Caco-2 Cell Monolayers and the DPPC Model Membrane. [Abstract]

2024 May 1;72(17):9828-9841. PMID: 38639269
Biol Direct

Nuclear respiratory factor 1 drives hepatocellular carcinoma progression by activating LPCAT1-ERK1/2-CREB axis. [Abstract]

2023 Oct 24;18(1):67. PMID: 37875967

DPPC purchased from MedChemExpress. Usage Cited in: Biol Direct. 2023 Oct 24;18(1):67. [Abstract]

The activation of ERK1/2-CREB pathway and NRF1 protein levels after LPCAT1 knockdown and DPPC (10 μM) supplementation were analysed by Western blot.
Molecules

Mixed Monolayer Characteristics of Tangeretin with Stearic Acid and Dipalmitoyl Phosphatidyl Choline at the Air/Water Interface. [Abstract]

2026 Jun 4;31(11):1952. PMID: 42280254
Spectrochim Acta A Mol Biomol Spectrosc

Study transport of hesperidin based on the DPPC lipid model and the BSA transport model. [Abstract]

2024 Jun 5:314:124172. PMID: 38513316
Traditional Medicine Research

2025;10(4):20.
Cancer Adv

2024;7:e24021.

Lösungsmittel & Löslichkeit

In Vitro:

Ethanol : 25 mg/mL (34.06 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.3623 mL

6.8116 mL

13.6232 mL

5 mM

0.2725 mL

1.3623 mL

2.7246 mL

10 mM

0.1362 mL

0.6812 mL

1.3623 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline

Solubility: 2.5 mg/mL (3.41 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% EtOH 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (3.41 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (647 KB)
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- Norwegian - NO (647 KB)
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- Swedish - SV (647 KB)
- Italian - IT (647 KB)
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- Portuguese - PT (647 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Miller AD. Delivery of RNAi therapeutics: work in progress. Expert Rev Med Devices. 2013 Nov;10(6):781-811. [Content Brief]

[2]. Akiko Uemura, et al. Induction of immune responses against glycosphingolipid antigens: comparison of antibody responses in mice immunized with antigen associated with liposomes prepared from various phospholipids. J Vet Med Sci. 2005 Dec;67(12):1197-201. [Content Brief]

[3]. Ege C, et al. Insertion of Alzheimer's A beta 40 peptide into lipid monolayers. Biophys J. 2004 Sep;87(3):1732-40. [Content Brief]

[4]. Kalra VK, et al. Transport of amino acids in gamma-glutamyl transpeptidase-implanted human erythrocytes. J Biol Chem. 1981 Jun 10;256(11):5567-71. [Content Brief]

[5]. Leekumjorn S, et al. Molecular simulation study of structural and dynamic properties of mixed DPPC/DPPE bilayers. Biophys J. 2006 Jun 1;90(11):3951-65. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
Ethanol	1 mM	1.3623 mL	6.8116 mL	13.6232 mL	34.0581 mL
	5 mM	0.2725 mL	1.3623 mL	2.7246 mL	6.8116 mL
	10 mM	0.1362 mL	0.6812 mL	1.3623 mL	3.4058 mL
	15 mM	0.0908 mL	0.4541 mL	0.9082 mL	2.2705 mL
	20 mM	0.0681 mL	0.3406 mL	0.6812 mL	1.7029 mL
	25 mM	0.0545 mL	0.2725 mL	0.5449 mL	1.3623 mL
	30 mM	0.0454 mL	0.2271 mL	0.4541 mL	1.1353 mL

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DPPC

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Publications Citing Use of MedChemExpress (MCE) DPPC

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (10)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

DPPC Related Classifications

HY-109506 Related Classifications