Art. -Nr.: HY-13104

MRS 2578

13 Cited Publications

Kundenbewertung

Based on 13 publication(s) in Google Scholar

MRS 2578 is a selective and potent P2Y6 receptor antagonist with IC₅₀s of 37 nM (human) and 98 nM (rat). MRS 2578 exhibits insignificant activity at P2Y1, P2Y2, P2Y4, and P2Y11 receptors.

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Reinheit: 99.50%
CAS. Nr.: 711019-86-2
Formel: C₂₀H₂₀N₆S₄
Molecular Weight:472.67

Speicherung:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

MRS 2578 Chemical Structure

CAS. Nr.: 711019-86-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (13)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

MRS 2578 is a selective and potent P2Y6 receptor antagonist with IC₅₀s of 37 nM (human) and 98 nM (rat). MRS 2578 exhibits insignificant activity at P2Y1, P2Y2, P2Y4, and P2Y11 receptors^[1]^[2].

IC₅₀ & Target

P2Y6 Receptor

Alle P2Y Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

MRS2578 (1 μM) completely blocks the protection by UDP undergoing TNFα-induced apoptosis in 1321N1 astrocytoma cells^[1].
MRS 2578 (10 μM) completely abolishes TNF-α induced NF-κB reporter activity in HMEC-1 cells. MRS 2578 (10 μM) significant reduces TNF-α–induced proinflammatory gene expression in HMEC-1 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MRS2578 (3 mg/kg; i.p.; for 3 days) significantly suppresses pressure overload-induced collagen deposition without affecting cardiomyocyte hypertrophy after transverse aortic constriction (TAC)^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

6-week-old male C57BL/6J mice^[4]
Dosage:

3 mg/kg
Administration:

Intraperitoneal injection; daily for 3 days after TAC
Result:

Significantly suppressed pressure overload-induced collagen deposition.

Chemical Information

CAS. Nr. 711019-86-2
Appearance Solid
Molecular Weight 472.67
Formel C₂₀H₂₀N₆S₄
Color White to off-white
SMILES

S=C(NCCCCNC(NC1=CC(N=C=S)=CC=C1)=S)NC2=CC(N=C=S)=CC=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (13)

All In Vivo Efficacy StudyHistological Imaging/StainingELISAWBIF

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Journal Impact Factor

Phytomedicine

Astilbin inhibited neutrophil extracellular traps in gouty arthritis through suppression of purinergic P2Y6 receptor. [Abstract]

2024 Jul 25:130:155754. PMID: 38820662

MRS 2578 purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Jul 25:130:155754. [Abstract]

MRS 2578 (3 mg/kg; daily; IP; for 7 consecutive days) showed that relief occurred and reversed the swelling caused by MSU in GA mice.

MRS 2578 purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Jul 25:130:155754. [Abstract]

MRS 2578 (3 mg/kg; daily; IP; for 7 consecutive days) improved inflammation and damage in ankle joints in GA mice.

MRS 2578 purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Jul 25:130:155754. [Abstract]

MRS 2578 (3 mg/kg; daily; IP; for 7 consecutive days) reversed MSU induced the increased of the levels of IL-1β, TNF-α, and IL-6 in GA mice.

MRS 2578 purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2024 Jul 25:130:155754. [Abstract]

MRS 2578 (3 mg/kg; daily; IP; for 7 consecutive days) reduced the expression of protein P2Y6R and CXCR2 stimulated by MSU in ankle joints of GA mice.
ACS Environ Au

Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]

2025 Aug 5;5(6):573-582. PMID: 41277996
Free Radic Biol Med

P2Y6 receptor blockade promotes depression-like symptoms through oxidative stress and impaired autophagy. [Abstract]

2025 Oct 17:242:203-219. PMID: 41110517

MRS 2578 purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Oct 17:242:203-219. [Abstract]

MRS 2578 (5 mg/kg; IP) exhibited robust depressive-like behaviors, including reduced sucrose preference (anhedonia), increased immobility in the tail suspension test (behavioral despair), and decreased locomotor activity and exploratory behavior in the open field test.

MRS 2578 purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Oct 17:242:203-219. [Abstract]

MRS 2578 (5 mg/kg; IP) significantly reduced the phosphorylation of IP3, PKC, CaMKII, calcineurin, TFEB, and NFAT2, while calreticulin levels increased in the hippocampus of mice.

MRS 2578 purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Oct 17:242:203-219. [Abstract]

MRS 2578 (5 mg/kg; IP) significantly reduced hippocampal NeuN expression of the hippocampus.
Cancer Immunol Res

The UDP/P2y6 axis promotes lung metastasis of melanoma by remodeling the premetastatic niche. [Abstract]

2020 Dec;17(12):1269-1271. PMID: 32144377
Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576
CNS Neurosci Ther

Overexpression of GRK6 alleviates chronic visceral hypersensitivity through downregulation of P2Y6 receptors in anterior cingulate cortex of rats with prenatal maternal stress. [Abstract]

2022 Jun;28(6):851-861. PMID: 35349212
Cell Oncol (Dordr)

P2RY6+ tumor-associated macrophages as a therapeutic target: suppressing tumor growth and enhancing chemosensitivity in triple-negative breast cancer. [Abstract]

2026 Jun 6. PMID: 42250059
Int Immunopharmacol

The immunoregulator β-glucan produces antidepressant effects through microglia-mobilized astrocytic P2Y1R-BDNF signaling in the dentate gyrus. [Abstract]

2025 Sep 6:165:115494. PMID: 40915186
Int Immunopharmacol

Inhibition of P2Y6 receptor expression in Kupffer cells alleviates alcoholic steatohepatitis in mice. [Abstract]

2022 Aug:109:108909. PMID: 35700583
Mol Neurobiol

P2Y6R Inhibition Induces Microglial M2 Polarization by Promoting PINK1/Parkin-Dependent Mitophagy After Spinal Cord Injury. [Abstract]

2025 Jun;62(6):7054-7074. PMID: 39607640
Am J Physiol Cell Physiol

ATP promotes resident CD34+ cell migration mainly through P2Y2-Stim1-ERK/p38 pathway. [Abstract]

2023 Nov 1;325(5):C1228-C1243. PMID: 37721000
Pharmacol Biochem Behav

Intranasal LAG3 antibody infusion induces microglia-dependent antidepressant effect by mobilizing astrocytic P2Y1R-mediated BDNF synthesis in the hippocampus. [Abstract]

2025 Dec:257:174114. PMID: 41106438
Research Square Preprint

2020 Aug.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (105.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.1156 mL

10.5782 mL

21.1564 mL

5 mM

0.4231 mL

2.1156 mL

4.2313 mL

10 mM

0.2116 mL

1.0578 mL

2.1156 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (644 KB)
- English - EN (644 KB)
- Français - FR (644 KB)
- Deutsch - DE (644 KB)
- Norwegian - NO (644 KB)
- Español - ES (644 KB)
- Swedish - SV (644 KB)
- Italian - IT (644 KB)
- Korean - KR (644 KB)
- Portuguese - PT (644 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Mamedova LK, et al. Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors. Biochem Pharmacol, 2004, 67(9), 1763-1770. [Content Brief]

[2]. Nishida M, et al. P2Y6 receptor-Galpha12/13 signalling in cardiomyocytes triggers pressure overload-induced cardiacfibrosis. EMBO J. 2008 Dec 3;27(23):3104-15. [Content Brief]

[3]. Riegel AK, et al. Selective induction of endothelial P2Y6 nucleotide receptor promotes vascular inflammation. Blood, 2011, 117(8), 2548-2555. [Content Brief]

[4]. Vieira RP, et al. Purinergic receptor type 6 contributes to airway inflammation and remodeling in experimental allergic airway inflammation. Am J Respir Crit Care Med, 2011, 184(2), 215-223. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.1156 mL	10.5782 mL	21.1564 mL	52.8910 mL
	5 mM	0.4231 mL	2.1156 mL	4.2313 mL	10.5782 mL
	10 mM	0.2116 mL	1.0578 mL	2.1156 mL	5.2891 mL
	15 mM	0.1410 mL	0.7052 mL	1.4104 mL	3.5261 mL
	20 mM	0.1058 mL	0.5289 mL	1.0578 mL	2.6446 mL
	25 mM	0.0846 mL	0.4231 mL	0.8463 mL	2.1156 mL
	30 mM	0.0705 mL	0.3526 mL	0.7052 mL	1.7630 mL
	40 mM	0.0529 mL	0.2645 mL	0.5289 mL	1.3223 mL
	50 mM	0.0423 mL	0.2116 mL	0.4231 mL	1.0578 mL
	60 mM	0.0353 mL	0.1763 mL	0.3526 mL	0.8815 mL
	80 mM	0.0264 mL	0.1322 mL	0.2645 mL	0.6611 mL
	100 mM	0.0212 mL	0.1058 mL	0.2116 mL	0.5289 mL

Keywords

MRS 2578

13 Cited Publications

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MRS 2578

Apoptosis Compound Library

GPCR/G Protein Compound Library

Anti-Cardiovascular Disease Compound Library

Neurotransmitter Receptor Compound Library

Targeted Diversity Library

Human Metabolite Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Highly Selective Inhibitors Library

Highly Selective Activators Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) MRS 2578

Alle P2Y Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (13)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

MRS 2578

Apoptosis Compound Library

GPCR/G Protein Compound Library

Anti-Cardiovascular Disease Compound Library

Neurotransmitter Receptor Compound Library

Targeted Diversity Library

Human Metabolite Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Highly Selective Inhibitors Library

Highly Selective Activators Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) MRS 2578

Alle P2Y Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (13)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

MRS 2578 Related Classifications

HY-13104 Related Classifications