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Pyridostatin

(Synonyms: RR82)
37 Cited Publications
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Based on 37 publication(s) in Google Scholar

Pyridostatin (RR82) is a G-quadruplex DNA stabilizing agent (Kd=490 nM) and can target DNA and RNA G4s in cells. Pyridostatin promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin targets the proto-oncogene Src. Pyridostatin reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form that retains the same biological activity.

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  • Reinheit : 96.03%
  • CAS. Nr.: 1085412-37-8
  • Formel: C31H32N8O5
  • Molecular Weight:596.64
  • Speicherung:
    Powder   -20°C, 3 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Pyridostatin Chemical Structure
    Pyridostatin Chemical Structure
  • Experimental Validation Results for Pyridostatin
  • Experimental Validation Results for Pyridostatin
  • Experimental Validation Results for Pyridostatin
  • Experimental Validation Results for Pyridostatin
  • Experimental Validation Results for Pyridostatin
CAS. Nr.: 1085412-37-8
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Cell Proliferation/Viability AssayRT-PCRWBHistological Imaging/Staining
  • Cell Proliferation/Viability Assay
  • RT-PCR
  • RT-PCR
  • WB
  • Histological Imaging/Staining

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  • Pyridostatin Chemical Structure
    Pyridostatin Chemical Structure
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    Pyridostatin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Sep 16;13(1):5456. [Abstract]

    Customer Validation
     Stacked bar graphs of zebrafish embryos in dead, deformd, and normal status with different G4 stabilizer (Pyridostatin hydrochloride, 0.05-20 ng/μL, 5 nL) concentration at 24 hpf (d) and 48 hpf (e).

  • 1/16

    Pyridostatin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Sep 16;13(1):5456. [Abstract]

    Customer Validation
     qRT-PCR measurement of shox. The mRNA expression level of the shoxgene was detected at different time points (3, 7, and 14 days post-fertilization; i.e., 3 dpf, 7 dpf, and 14 dpf). The results showed that, compared with wild-type zebrafish, the G4 stabilizer Pyridostatin hydrochloride (0.05-0.1 ng/μL) significantly reduced the shox mRNA expression level in wrn−/− zebrafish.

  • 1/16

    Pyridostatin purchased from MedChemExpress. Usage Cited in: J Hepatol. 2020 Aug;73(2):371-382. [Abstract]

    Customer Validation
     Levels of miR-26a in MPHs transfected with miR-26a-WT or miR-26a-G4mut plasmids and stimulated with Pyridostatin hydrochloride (PDS, 10 μM; 48 h). The results showed that PDS significantly diminished the increase in miR-26a expression induced by miR-26a-WT plasmids, but not by miR-26a-G4mut plasmids, indicating that the G/A mutations are sufficient to abolish the inhibitory effect of PDS on miR-26a expression.

  • 1/16

    Pyridostatin purchased from MedChemExpress. Usage Cited in: J Hepatol. 2020 Aug;73(2):371-382. [Abstract]

    Customer Validation
     Pyridostatin hydrochloride (PDS, 10 μM; 48 h) markedly inhibited insulin-induced AKT activation, a central hallmark of insulin sensitivity, in MPHs (isolated from C57BL/6 mice) transfected with miR-26a-WT plasmids.

  • 1/16

    Pyridostatin purchased from MedChemExpress. Usage Cited in: J Hepatol. 2020 Aug;73(2):371-382. [Abstract]

    Customer Validation
     8- to 10-week-old mice were infused with Pyridostatin hydrochloride (PDS, 6 mg/kg body weight) or saline (NC) via caudal vein twice a day (n = 5). 12 h post the second injection, the following measurements were performed. Representative H&E staining of paraffin liver sections. Scale bars: 20 μm. The results showed that no significant differences in histology and morphology were observed between PDS-treated mice and saline-treated mice.

  • Pyridostatin