VR23
Based on 1 publication(s) in Google Scholar
VR23 is a small molecule that potently inhibits the activities of trypsin-like proteasomes (IC50=1 nM), chymotrypsin-like proteasomes (IC50=50-100 nM), and caspase-like proteasomes (IC50=3 μM).
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- Reinheit: 99.58%
- CAS. Nr.: 1624602-30-7
- Formel: C19H16ClN5O6S
- Molecular Weight:477.88
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) VR23
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Biologische Aktivität
IC50: 1 nM (trypsin-like proteasome), 50-100 nM (chymotrypsin-like proteasome), 3 μM (caspase-like proteasome)
VR23 is a novel proteasome inhibitor targeting β2 of the 20S proteasome subunit. VR23 produces a synergistic effect in killing multiple myeloma cells, including those that were resistant to PS-341. VR23 as a structurally novel proteasome inhibitor with desirable properties as an anticancer agent.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1624602-30-7
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Appearance Solid
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Molecular Weight 477.88
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Formel C19H16ClN5O6S
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Color Light yellow to yellow
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SMILES
O=S(N1CCN(C2=CC=NC3=CC(Cl)=CC=C23)CC1)(C4=CC=C([N+]([O-])=O)C=C4[N+]([O-])=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Dig Dis Sci
Protease Inhibitor VR23 Alleviates Severe Acute Pancreatitis with High Trypsin Synthesis in Mice. [Abstract]2025 Jun 2. PMID: 40455346
Lösungsmittel & Löslichkeit
DMSO : 33.33 mg/mL (69.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0926 mL | 10.4629 mL | 20.9258 mL | 52.3144 mL |
| 5 mM | 0.4185 mL | 2.0926 mL | 4.1852 mL | 10.4629 mL | |
| 10 mM | 0.2093 mL | 1.0463 mL | 2.0926 mL | 5.2314 mL | |
| 15 mM | 0.1395 mL | 0.6975 mL | 1.3951 mL | 3.4876 mL | |
| 20 mM | 0.1046 mL | 0.5231 mL | 1.0463 mL | 2.6157 mL | |
| 25 mM | 0.0837 mL | 0.4185 mL | 0.8370 mL | 2.0926 mL | |
| 30 mM | 0.0698 mL | 0.3488 mL | 0.6975 mL | 1.7438 mL | |
| 40 mM | 0.0523 mL | 0.2616 mL | 0.5231 mL | 1.3079 mL | |
| 50 mM | 0.0419 mL | 0.2093 mL | 0.4185 mL | 1.0463 mL | |
| 60 mM | 0.0349 mL | 0.1744 mL | 0.3488 mL | 0.8719 mL |
VR23 Related Classifications
HY-18741 Related Classifications
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