AM-8722

AM-8722 selectively inhibits DNA replication in S. aureus with an IC₅₀ of 1.10 μg/mL^[1].
AM-8722 is a potent inhibitor of bacterial DNA gyrase and topoisomerase IV from S. aureus and E. coli, with IC₅₀s of 0.83 μM and 0.14 μM for DNA gyrase, respectively, and is selective against human topoisomerase II^[1].
AM-8722 exhibits potent broad-spectrum antibacterial activity against various Gram-positive and Gram-negative organisms, including resistant strains^[1].
The antibacterial activity of AM-8722 against S. aureus RN4220 is unaffected by the presence of excess DNA or human serum, with an MIC of 0.125 μg/mL^[1].
AM-8722 displays potent in vitro activity against a broad panel of clinical isolates, including Staphylococcus, Acinetobacter, H. influenzae, and M. catarrhalis^[1].
AM-8722.HCl exhibits potent and rapid bactericidal activity against S. aureus ATCC 29213 at concentrations of 1 μg/mL and above, with no regrowth at 16× MIC or higher^[1].
AM-8722 (compound 6) (0.031-8 μg/mL) shows broad-spectrum antibacterial activity with MIC values of 0.031 μg/mL against Staphylococcus aureus Smith, 0.5 μg/mL against Streptococcus pneumoniae IID553, 2 μg/mL against Enterococcus faecium VanA (VRE), 2 μg/mL against Escherichia coli ATCC 25922, 0.25 μg/mL against Acinetobacter baumannii IID876, and 8 μg/mL against Pseudomonas aeruginosa PAO1^[2].
AM-8722 is a substrate for human, rat, and mouse P-glycoprotein (Pgp), as demonstrated by BA/AB ratios of >27.1, >21.5, and 24.7 in LLC-MDR1, LLC-Mdr1a, and LLC-Mdr1a cells, respectively^[1].
AM-8722 exhibits high apparent permeability across MDCKII monolayers with a P_app of 23.6 × 10⁻⁶ cm/s^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.