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Art. -Nr.: HY-155018

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Anticancer agent 127

Name: Anticancer agent 127
Brand: MedChemExpress
SKU: HY-155018
Price: 220.00 USD
Availability: InStock
Rating: 5 (1 reviews)

Anticancer agent 127 (142D6) is an IAP inhibitor that covalently targets the BIR3 domains of XIAP, cIAP1, and cIAP2. Anticancer agent 127 targets the BIR3 domains of XIAP, cIAP1, and cIAP2 with IC₅₀s of 12 nM, 14 nM, and 9 nM, respectively. Anticancer agent 127 has anticancer effects.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2410953-19-2
Formel: C₂₆H₃₇FN₄O₆S
Molecular Weight:552.66

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Anticancer agent 127 Chemical Structure

CAS. Nr.: 2410953-19-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC50: 12 nM (XIAP-BIR3), 14 nM (cIAP1-BIR3), and 9 nM (cIAP2-BIR3)^[1]

Alle IAP Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-231	EC₅₀	44 nM Compound: 142D6	Cytotoxicity in human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by IncuCyte live-cell imaging analysis Cytotoxicity in human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by IncuCyte live-cell imaging analysis	[PMID: 37262387]
MDA-MB-231	EC₅₀	61 nM Compound: 142D6	Induction of apoptosis in human MDA-MB-231 cells Induction of apoptosis in human MDA-MB-231 cells	[PMID: 37262387]
MDA-MB-231	EC₅₀	94.2 nM Compound: 142D6	Cytotoxicity against human MDA-MB-231 cells cultured as 3D spheroids incubated for 6 days and measured every 6 hrs by IncuCyte live-cell analysis Cytotoxicity against human MDA-MB-231 cells cultured as 3D spheroids incubated for 6 days and measured every 6 hrs by IncuCyte live-cell analysis	[PMID: 37262387]

Chemical Information

CAS. Nr. 2410953-19-2
Molecular Weight 552.66
Formel C₂₆H₃₇FN₄O₆S
SMILES

O=C(N1[C@H](C(N[C@H]2C(C=CC=C3OS(=O)(F)=O)=C3CC2)=O)CCC1)[C@H](C4CCCCC4)NC([C@H](C)NC)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Udompholkul P, et al. Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist. J Med Chem. 2023 Jun 22;66(12):8159-8169. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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