Antimalarial agent 41
Antimalarial agent 41 (Compound 17) exhibits antimalarial activity, which inhibits Plasmodium falciparum with an IC50 of 40 nM (NF54 strain) and 76 nM (K1 strain). Antimalarial agent 41 is an inhibitor for P. falciparum phosphatidylinositol-4-kinase β (Pf PI4K) and hERG channel, with an IC50 of 53 nM and 3 μM. Antimalarial agent 41 exhibits cytotoxicity to CHO cells with an IC50 of 34 μM. Antimalarial agent 41 ameliorates the malaria infection and exhibits good pharmacokinetic characters in mouse models.
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- Formel: C19H18F3N5
- Molecular Weight:373.37
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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Pf PI4K 53 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| CHO | IC50 |
34 μM
Compound: 17
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Cytotoxicity against CHO cells measured after 48 hrs by MTT assay
Cytotoxicity against CHO cells measured after 48 hrs by MTT assay
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[PMID: 38918002] |
Chemical Information
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Molecular Weight 373.37
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Formel C19H18F3N5
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SMILES
FC(C1=CC=C(C2=CC=C3N=CC=C(NC4CCNCC4)C3=N2)C=N1)(F)F
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Antimalarial agent 41 Related Classifications
HY-163765 Related Classifications
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