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Art. -Nr.: HY-130410

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Bis-PEG6-NHS ester

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Bis-PEG6-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG6-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

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Reinheit: 98.0%
CAS. Nr.: 1526718-98-8
Formel: C₂₄H₃₆N₂O₁₄
Molecular Weight:576.55

Speicherung:

-20°C, sealed storage, away from moisture

* The compound is unstable in solutions, freshly prepared is recommended.

Bis-PEG6-NHS ester Chemical Structure

CAS. Nr.: 1526718-98-8

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Bis-PEG6-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG6-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1].

IC₅₀ & Target^[1]

Cleavable Linker

PEGs

Alkyl/ether

Alle ADC Linkers Isoform-spezifische Produkte anzeigen :

Alle PROTAC Linkers Isoform-spezifische Produkte anzeigen :

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1526718-98-8
Appearance Viscous Liquid
Molecular Weight 576.55
Formel C₂₄H₃₆N₂O₁₄
Color Colorless to light yellow
SMILES

O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCC(ON2C(CCC2=O)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, sealed storage, away from moisture

* The compound is unstable in solutions, freshly prepared is recommended.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 100 mg/mL (173.45 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.7345 mL

8.6723 mL

17.3445 mL

5 mM

0.3469 mL

1.7345 mL

3.4689 mL

10 mM

0.1734 mL

0.8672 mL

1.7345 mL

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. John L. Magna, et al. Highly potent multimeric e-selectin antagonists. WO2018068010A1.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.7345 mL	8.6723 mL	17.3445 mL	43.3614 mL
	5 mM	0.3469 mL	1.7345 mL	3.4689 mL	8.6723 mL
	10 mM	0.1734 mL	0.8672 mL	1.7345 mL	4.3361 mL
	15 mM	0.1156 mL	0.5782 mL	1.1563 mL	2.8908 mL
	20 mM	0.0867 mL	0.4336 mL	0.8672 mL	2.1681 mL
	25 mM	0.0694 mL	0.3469 mL	0.6938 mL	1.7345 mL
	30 mM	0.0578 mL	0.2891 mL	0.5782 mL	1.4454 mL
	40 mM	0.0434 mL	0.2168 mL	0.4336 mL	1.0840 mL
	50 mM	0.0347 mL	0.1734 mL	0.3469 mL	0.8672 mL
	60 mM	0.0289 mL	0.1445 mL	0.2891 mL	0.7227 mL
	80 mM	0.0217 mL	0.1084 mL	0.2168 mL	0.5420 mL
	100 mM	0.0173 mL	0.0867 mL	0.1734 mL	0.4336 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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Bis-PEG6-NHS ester

Alle ADC Linkers Isoform-spezifische Produkte anzeigen

Alle PROTAC Linkers Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Bis-PEG6-NHS ester Related Classifications

HY-130410 Related Classifications