BM213
Based on 3 publication(s) in Google Scholar
BM213 is a selective C5aR agonist, with an EC50 of 59 nM. BM213 specifically activates the C5a-C5aR1 axis, which in turn promotes neutrophil extracellular trap (NET) formation and exacerbates inflammatory responses. BM213 significantly induces ventricular dilationin, promotes myocardial ROS production, and induces cardiomyocyte apoptosis in rats. BM213 can be used for the study of myocardial ischemia/reperfusion (I/R) injury.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.81%
- CAS. Nr.: 2891606-02-1
- Formel: C43H70N12O10
- Molecular Weight:915.09
-
Speicherung:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
-
Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) BM213
More
Biologische Aktivität
|
C5aR 59 nM (EC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male Sprague-Dawley (SD) rats (200±20 g)[1]
-
Dosage:1 mg/kg
-
Administration:i.p., once daily in the evening, 3 days
-
Result:Induced significant ventricular dilation.
Elevated serum levels of CK-MB, cTnT and IL-1β.
Up-regulated plasma concentrations of C5a, C5b-9, CCL3, CXCL1 and NETs.
Increased myocardial mRNA expression of C5ar1, Mpo and Ne.
Enhanced myocardial protein levels of C5aR1, MPO, NE and CitH3.
Promoted myocardial ROS production.
Induced cardiomyocyte apoptosis.
Chemical Information
-
CAS. Nr. 2891606-02-1
-
Appearance Solid
-
Molecular Weight 915.09
-
Formel C43H70N12O10
-
Color White to off-white
-
Sequence
Ac-Phe-Lys-Pro-Leu-Ala-Ala-Ala-Arg
-
Sequence Shortening
Ac-FKPLAAAR
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (3)
-
Journal Impact Factor
-
Most Recent
-
Eur J Pharmacol
Ursolic acid ameliorates doxorubicin-induced cardiotoxicity by inhibiting DRP1-mediated excessive mitochondrial fission and oxidative stress. [Abstract]2026 Jan 20:1012:178482. PMID: 41412262 -
J Neurochem
Complement C3a and C5a Receptors Are Presented in Mouse Sciatic and Human Sural Nerves and Selectively Modulate the Neuronal Function of Large-Caliber Fibers in Mice. [Abstract]2025 Jun;169(6):e70129. PMID: 40539483 -
Med Microbiol Immunol
Exploration of compounds to inhibit the Panton-Valentine leukocidin of Staphylococcus aureus. [Abstract]2024 Sep 19;213(1):19. PMID: 39297970
Lösungsmittel & Löslichkeit
H2O : 50 mg/mL (54.64 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (109.28 mM); Clear solution; Need ultrasonic
Reinheit & Dokumentation
-
Data Sheet (277 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
Verweise
[1]. Zhang M, et al. 13-methylpalmatine alleviates myocardial ischemia/reperfusion injury by potentially targeting the C5a-C5aR1 axis to inhibit neutrophil extracellular trap formation. Redox Biol. 2025 Aug 5;86:103802. [Content Brief]
[2]. Gorman DM, et al. Development of Potent and Selective Agonists for Complement C5a Receptor 1 with In Vivo Activity. J Med Chem. 2021 Nov 25;64(22):16598-16608. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.0928 mL | 5.4639 mL | 10.9279 mL | 27.3197 mL |
| 5 mM | 0.2186 mL | 1.0928 mL | 2.1856 mL | 5.4639 mL | |
| 10 mM | 0.1093 mL | 0.5464 mL | 1.0928 mL | 2.7320 mL | |
| 15 mM | 0.0729 mL | 0.3643 mL | 0.7285 mL | 1.8213 mL | |
| 20 mM | 0.0546 mL | 0.2732 mL | 0.5464 mL | 1.3660 mL | |
| 25 mM | 0.0437 mL | 0.2186 mL | 0.4371 mL | 1.0928 mL | |
| 30 mM | 0.0364 mL | 0.1821 mL | 0.3643 mL | 0.9107 mL | |
| 40 mM | 0.0273 mL | 0.1366 mL | 0.2732 mL | 0.6830 mL | |
| 50 mM | 0.0219 mL | 0.1093 mL | 0.2186 mL | 0.5464 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
BM213 Related Classifications
HY-145237 Related Classifications
Powered by Bioz