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Art. -Nr.: HY-173084

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BRD6257

BRD6257 is an orally active inhibitor for protein phosphatase, Mg2+/Mn2+ dependent 1D PPM1D with an IC₅₀ of 5 nM. BRD6257 activates p53 signaling pathway with an EC₅₀ of 51 nM, increases the p21 expression, inhibits the proliferation of cancer cell MOLM13 (IC₅₀=2.8 μM). BRD6257 exhibits good metabolic stability in human and rat liver microsomes.

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Formel: C₂₄H₂₂F₄N₆O₃S
Molecular Weight:550.53

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

BRD6257 Chemical Structure

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Use of MCE Products

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Parmacokinetics
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Parmacokinetics

Species	Dose	Route	C₀	T_1/2	CL	V_dss	AUC	C_max	T_max	AUC_0-inf	Bioavailability
Mice^[1]	1 mg/kg	i.v.	4664 ng/mL	0.8 h	5.4 mL/min/kg	0.29 L/kg	3085 ng·h/mL	/	/	/	/
Mice^[1]	10 mg/kg	p.o.	/	0.89 h	/	/	/	145 ng/mL	1.3 h	366 ng·h/mL	12 %

Chemical Information

Molecular Weight 550.53
Formel C₂₄H₂₂F₄N₆O₃S
SMILES

FC(F)C1=CC=C(NC([C@@H](NC2=NN3C(C=C(N=C3S2)C4=NC=C(C)O4)=O)CC5CCC(F)(C5)F)=O)C=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Shaw S, et al. Identification of Small Molecule Inhibitors of PPM1D Using an Integrated Drug Discovery Platform[J]. iScience, 2025.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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