Cemadotin
Cemadotin (LU103793) is a water-soluble synthetic analogue of Dolastatin 15 (HY-P1126) that inhibits cell proliferation in vitro and the growth of tumor xenografts in mice. Cemadotin blocks cells at mitosis, and exhibits Ki value of 1 μM for inhibiting tubulin. Cemadotin can be used to research anticancer.
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- CAS. Nr.: 159776-69-9
- Formel: C35H56N6O5
- Molecular Weight:640.86
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Ki: 1 μM (tubulin)[1]
Cemadotin (0-100 μM; 35 min) inhibits polymerization dose-dependently in Tubulin-treated Strongylocentrotus purpuratus[1].
Cemadotin (0-1000 nM) preferentially suppresses the rate and extent of growing excursions of tubulin, and suppression is dependent upon the drug concentration[1].
Cemadotin (0-1 μM) markedly increases the rescue frequency but had little effect on the catastrophe frequency[1].
Cemadotin (400 pM~300 nM; 72 h) inhibits cancer cells HEK 293, F9 and HL60[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK 293, F9 and HL60
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Concentration:400 pM~300 nM
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Incubation Time:72 h
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Result:Exhibited cytotoxicity against HEK 293, F9 and HL60 with IC50s of 0.7 nM, 14.8 nM and 0.5 nM, respectively.
Chemical Information
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CAS. Nr. 159776-69-9
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Molecular Weight 640.86
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Formel C35H56N6O5
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Synonyms
LU103793 free base
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Jordan MA, et al. Suppression of microtubule dynamics by binding of cemadotin to tubulin: possible mechanism for its antitumor action. Biochemistry. 1998 Dec 15;37(50):17571-8. [Content Brief]
[2]. Bernardes GJ, et al. A traceless vascular-targeting antibody-drug conjugate for cancer therapy. Angew Chem Int Ed Engl. 2012 Jan 23;51(4):941-4. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Cemadotin Related Classifications
HY-13589 Related Classifications
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